CRCGN015_MCF10A_48H:A16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description shahrm perturbation at 48 h in MCF10A (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

330 genes differentially expressed following the CRCGN015_MCF10A_48H:A16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 4.59132
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 3.73145
COQ8A coenzyme Q8A 3.60544
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.42927
LOC128966622 putative protein N-methyltransferase FAM86B2 3.31904
WIF1 WNT inhibitory factor 1 3.305
RAD54L2 RAD54-like 2 (S. cerevisiae) 3.28943
CDT1 chromatin licensing and DNA replication factor 1 3.19768
ACTMAP actin maturation protease 3.13338
HIRIP3 HIRA interacting protein 3 3.11162
USP11 ubiquitin specific peptidase 11 3.1
E2F8 E2F transcription factor 8 3.08517
WDHD1 WD repeat and HMG-box DNA binding protein 1 3.01951
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 3.00419
ADAM10 ADAM metallopeptidase domain 10 2.96664
ADAT1 adenosine deaminase, tRNA-specific 1 2.90822
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.86479
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.83316
ARMCX2 armadillo repeat containing, X-linked 2 2.82351
FANCG Fanconi anemia, complementation group G 2.81792
ADA2 adenosine deaminase 2 2.78153
MSH2 mutS homolog 2 2.76402
PRKCH protein kinase C, eta 2.72226
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.68526
CA3 carbonic anhydrase III 2.66413
RAD54B RAD54 homolog B (S. cerevisiae) 2.63437
CCNH cyclin H 2.62232
NT5DC2 5'-nucleotidase domain containing 2 2.62015
DUSP6 dual specificity phosphatase 6 2.60015
HBA1 hemoglobin, alpha 1 2.58728
MIS18A MIS18 kinetochore protein A 2.5722
MRPL37 mitochondrial ribosomal protein L37 2.52126
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.51785
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.50716
WRN Werner syndrome, RecQ helicase-like 2.48278
CHPF chondroitin polymerizing factor 2.47975
THAP7 THAP domain containing 7 2.47824
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.44868
MB myoglobin 2.43232
CENPQ centromere protein Q 2.43204
DPYSL3 dihydropyrimidinase-like 3 2.41937
ZNF232 zinc finger protein 232 2.41571
NCKIPSD NCK interacting protein with SH3 domain 2.40795
MMP2 matrix metallopeptidase 2 2.39712
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.39684
WDR76 WD repeat domain 76 2.3831
PTPRC protein tyrosine phosphatase, receptor type, C 2.3765
ERCC6L excision repair cross-complementation group 6-like 2.37143
FMNL3 formin-like 3 2.37141
PTH2R parathyroid hormone 2 receptor 2.36079
UCMA upper zone of growth plate and cartilage matrix associated 2.34543
RIBC2 RIB43A domain with coiled-coils 2 2.33059
STARD7 StAR-related lipid transfer (START) domain containing 7 2.32281
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.32113
PNOC prepronociceptin 2.31847
CORO1A coronin, actin binding protein, 1A 2.31145
ARRB2 arrestin, beta 2 2.31122
DOK5 docking protein 5 2.30371
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 2.29889
EXO1 exonuclease 1 2.28724
KLHL12 kelch-like family member 12 2.28182
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.27706
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.27174
SPC25 SPC25, NDC80 kinetochore complex component 2.25432
KLHL21 kelch-like family member 21 2.25296
CNOT3 CCR4-NOT transcription complex, subunit 3 2.25228
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.24454
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.22848
FAM114A1 family with sequence similarity 114, member A1 2.22566
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.22193
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.22077
MAGEA6 melanoma antigen family A6 2.21566
PEX14 peroxisomal biogenesis factor 14 2.21022
KIF18A kinesin family member 18A 2.20899
DCAF15 DDB1 and CUL4 associated factor 15 2.20818
SUSD4 sushi domain containing 4 2.20817
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.20748
TTC31 tetratricopeptide repeat domain 31 2.20494
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.2008
FOXF2 forkhead box F2 2.19163
AURKB aurora kinase B 2.18967
TMEM39B transmembrane protein 39B 2.18596
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.18572
SKA1 spindle and kinetochore associated complex subunit 1 2.17892
FST follistatin 2.17188
DCP1A decapping mRNA 1A 2.16573
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.16094
KIF22 kinesin family member 22 2.15697
NELL2 NEL-like 2 (chicken) 2.15602
KNTC1 kinetochore associated 1 2.15499
ILF2 interleukin enhancer binding factor 2 2.14957
ZNF304 zinc finger protein 304 2.14566
OXTR oxytocin receptor 2.13878
NCAPD2 non-SMC condensin I complex, subunit D2 2.13561
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 2.13514
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.13415
ZNF34 zinc finger protein 34 2.13355
PRIM2 primase, DNA, polypeptide 2 (58kDa) 2.13312
ZBTB48 zinc finger and BTB domain containing 48 2.13107
MARK1 MAP/microtubule affinity-regulating kinase 1 2.1295
MCPH1 microcephalin 1 2.1286
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.12717
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.12103
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.12055
RAD54L RAD54-like (S. cerevisiae) 2.11706
ASF1B anti-silencing function 1B histone chaperone 2.11505
BCL9 B-cell CLL/lymphoma 9 2.11211
GCLM glutamate-cysteine ligase, modifier subunit 2.11198
R3HCC1L R3H domain and coiled-coil containing 1-like 2.10757
MN1 meningioma (disrupted in balanced translocation) 1 2.10114
ZBTB14 zinc finger and BTB domain containing 14 2.09786
LOC100533997 MAGEA10-MAGEA5 readthrough 2.09443
HAT1 histone acetyltransferase 1 2.0894
LRRC47 leucine rich repeat containing 47 2.08808
DOCK4 dedicator of cytokinesis 4 2.08591
ACTA1 actin, alpha 1, skeletal muscle 2.08461
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.08362
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.07587
BCKDK branched chain ketoacid dehydrogenase kinase 2.07432
XCL1 chemokine (C motif) ligand 1 2.0731
CDC7 cell division cycle 7 2.0701
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 2.06331
L1TD1 LINE-1 type transposase domain containing 1 2.06117
MYOM2 myomesin 2 2.06093
SCN3A sodium channel, voltage gated, type III alpha subunit 2.05893
POLR1B polymerase (RNA) I polypeptide B, 128kDa 2.05848
WNT5A wingless-type MMTV integration site family, member 5A 2.05595
GINS3 GINS complex subunit 3 (Psf3 homolog) 2.05519
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.05161
CBX7 chromobox homolog 7 2.04566
CSAG2 CSAG family, member 2 2.04368
PYCR3 pyrroline-5-carboxylate reductase 3 2.04085
SSX4B synovial sarcoma, X breakpoint 4B 2.03946
TNNT1 troponin T type 1 (skeletal, slow) 2.03671
FKBP11 FK506 binding protein 11, 19 kDa 2.03599
RNF31 ring finger protein 31 2.0353
ZHX2 zinc fingers and homeoboxes 2 2.02788
CYTIP cytohesin 1 interacting protein 2.02306
ANO10 anoctamin 10 2.02228
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 2.01967
ADA adenosine deaminase 2.01909
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.01841
CLIC2 chloride intracellular channel 2 2.01618
OIP5 Opa interacting protein 5 2.01524
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 2.01463
TMEM177 transmembrane protein 177 2.01154
CHST10 carbohydrate sulfotransferase 10 2.0107
ABI2 abl-interactor 2 2.00775
POT1 protection of telomeres 1 2.00291
GPN2 GPN-loop GTPase 2 2.00155

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -7.71689
PLK2 polo-like kinase 2 -6.85424
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.91038
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.18183
UFM1 ubiquitin-fold modifier 1 -4.06273
ANXA3 annexin A3 -4.05087
BAG3 BCL2-associated athanogene 3 -3.90974
NPDC1 neural proliferation, differentiation and control, 1 -3.85367
DNM1L dynamin 1-like -3.8225
CAB39 calcium binding protein 39 -3.59622
TRAPPC3 trafficking protein particle complex 3 -3.47856
WASHC4 WASH complex subunit 4 -3.45177
OAT ornithine aminotransferase -3.42415
MVP major vault protein -3.37061
RSU1 Ras suppressor protein 1 -3.35931
KRT14 keratin 14, type I -3.21965
DUSP14 dual specificity phosphatase 14 -3.18312
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.15163
CRNN cornulin -3.10389
INSIG1 insulin induced gene 1 -3.09226
CLTB clathrin, light chain B -3.08176
BAZ1A bromodomain adjacent to zinc finger domain, 1A -3.04838
SPRR1B small proline-rich protein 1B -3.04718
MRPS15 mitochondrial ribosomal protein S15 -3.03611
NCK1 NCK adaptor protein 1 -3.03566
SLC44A4 solute carrier family 44, member 4 -2.98922
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.98379
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.96861
STEAP4 STEAP family member 4 -2.91457
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.90387
TDG thymine-DNA glycosylase -2.85258
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.84942
MED21 mediator complex subunit 21 -2.82207
CEMIP2 cell migration inducing hyaluronidase 2 -2.81312
SPRR2B small proline-rich protein 2B -2.81272
TCERG1 transcription elongation regulator 1 -2.78182
TJP1 tight junction protein 1 -2.72438
FAM53C family with sequence similarity 53, member C -2.69773
LRP10 low density lipoprotein receptor-related protein 10 -2.68228
EDF1 endothelial differentiation-related factor 1 -2.6759
HDAC1 histone deacetylase 1 -2.67346
TGM1 transglutaminase 1 -2.6693
TM9SF2 transmembrane 9 superfamily member 2 -2.66455
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.6303
JPT1 Jupiter microtubule associated homolog 1 -2.61324
UBE2N ubiquitin-conjugating enzyme E2N -2.6002
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.59516
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.58985
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.56758
PPA1 pyrophosphatase (inorganic) 1 -2.53064
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.52511
TDRD7 tudor domain containing 7 -2.5176
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.51044
CRCT1 cysteine-rich C-terminal 1 -2.49645
RAB11A RAB11A, member RAS oncogene family -2.47277
PPP4R1 protein phosphatase 4, regulatory subunit 1 -2.47025
ELOVL6 ELOVL fatty acid elongase 6 -2.46182
HARS1 histidyl-tRNA synthetase 1 -2.45354
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.44619
CDC42SE1 CDC42 small effector 1 -2.4342
JAK1 Janus kinase 1 -2.43017
XAF1 XIAP associated factor 1 -2.42712
ENDOG endonuclease G -2.42584
DMAC2L distal membrane arm assembly component 2 like -2.42407
COBL cordon-bleu WH2 repeat protein -2.42106
SPRR1A small proline-rich protein 1A -2.40673
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.39975
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -2.39931
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.39668
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.38917
VAMP8 vesicle-associated membrane protein 8 -2.38632
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.38439
MPZL2 myelin protein zero-like 2 -2.37695
PDLIM2 PDZ and LIM domain 2 (mystique) -2.37242
KRT7 keratin 7, type II -2.36924
ERGIC2 ERGIC and golgi 2 -2.36819
TMPRSS11D transmembrane protease, serine 11D -2.36731
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.36231
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -2.35962
TSPO translocator protein (18kDa) -2.35462
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.35369
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.35174
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.35064
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -2.3471
LGALSL lectin, galactoside-binding-like -2.34653
TNS2 tensin 2 -2.34122
STX12 syntaxin 12 -2.31974
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.31544
MFSD1 major facilitator superfamily domain containing 1 -2.31413
NPEPPS aminopeptidase puromycin sensitive -2.30596
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.29921
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.29109
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.28609
DSG3 desmoglein 3 -2.2802
UBL5 ubiquitin-like 5 -2.26282
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.26069
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.25174
RESF1 retroelement silencing factor 1 -2.25107
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.24989
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -2.249
IVL involucrin -2.24068
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.23679
RLF rearranged L-myc fusion -2.23595
PTS 6-pyruvoyltetrahydropterin synthase -2.23591
ARL17B ADP-ribosylation factor-like 17B -2.23403
S100A8 S100 calcium binding protein A8 -2.22268
ZFP30 ZFP30 zinc finger protein -2.22255
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.21996
USP6NL USP6 N-terminal like -2.21755
DENR density-regulated protein -2.21412
WSB2 WD repeat and SOCS box containing 2 -2.214
ACOT9 acyl-CoA thioesterase 9 -2.21256
NUP58 nucleoporin 58 -2.20905
ADIPOR2 adiponectin receptor 2 -2.20685
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.2064
RAB5IF RAB5 interacting factor -2.20357
DYSF dysferlin -2.20304
UBL3 ubiquitin-like 3 -2.20261
HCFC2 host cell factor C2 -2.20002
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.19033
NIT2 nitrilase family, member 2 -2.18553
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.18312
HSPB8 heat shock 22kDa protein 8 -2.16837
CDC42 cell division cycle 42 -2.16505
AVEN apoptosis, caspase activation inhibitor -2.16148
ESYT1 extended synaptotagmin-like protein 1 -2.15978
KRT6B keratin 6B, type II -2.15278
CRY1 cryptochrome circadian clock 1 -2.15141
MAP7 microtubule-associated protein 7 -2.15064
GSTK1 glutathione S-transferase kappa 1 -2.15061
RHCG Rh family, C glycoprotein -2.15023
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.14882
BSPRY B-box and SPRY domain containing -2.14155
RALGDS ral guanine nucleotide dissociation stimulator -2.13767
NPR2 natriuretic peptide receptor 2 -2.12978
PCDHB16 protocadherin beta 16 -2.12034
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.11983
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.1116
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.10815
MAP7D1 MAP7 domain containing 1 -2.10531
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.10241
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.09894
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.09337
PYGL phosphorylase, glycogen, liver -2.09117
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.08753
DYNLL1 dynein, light chain, LC8-type 1 -2.08542
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.07344
POMP proteasome maturation protein -2.07029
SH3YL1 SH3 and SYLF domain containing 1 -2.0642
EAPP E2F-associated phosphoprotein -2.06274
NPY1R neuropeptide Y receptor Y1 -2.06177
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.06038
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.06018
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -2.05875
GLRB glycine receptor, beta -2.05808
RPS25 ribosomal protein S25 -2.05603
SRSF2 serine/arginine-rich splicing factor 2 -2.05595
GTPBP8 GTP-binding protein 8 (putative) -2.05448
MRPL42 mitochondrial ribosomal protein L42 -2.05376
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.0531
NHP2 NHP2 ribonucleoprotein -2.05289
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.05229
RPS26 ribosomal protein S26 -2.05088
BHLHE40 basic helix-loop-helix family, member e40 -2.04835
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -2.04751
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -2.04101
CHPT1 choline phosphotransferase 1 -2.04062
LARP4 La ribonucleoprotein domain family, member 4 -2.03035
AGR2 anterior gradient 2 -2.02457
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.02446
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.01853
ASB6 ankyrin repeat and SOCS box containing 6 -2.01447
SIAH2 siah E3 ubiquitin protein ligase 2 -2.01286
PLBD1 phospholipase B domain containing 1 -2.01283
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.01229
MGST3 microsomal glutathione S-transferase 3 -2.00938
LIMA1 LIM domain and actin binding 1 -2.00477
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.00402
EI24 etoposide induced 2.4 -2.00046
RAB25 RAB25, member RAS oncogene family -2.00013