CRCGN015_MCF10A_48H:A18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description shahrm perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

311 genes differentially expressed following the CRCGN015_MCF10A_48H:A18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 4.52985
PDIA5 protein disulfide isomerase family A, member 5 3.89351
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 3.84249
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.70512
ENDOG endonuclease G 2.68169
LAGE3 L antigen family, member 3 2.67048
RPS5 ribosomal protein S5 2.63933
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.47412
RRAGA Ras-related GTP binding A 2.45012
CHEK2 checkpoint kinase 2 2.43278
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.37351
TMEM11 transmembrane protein 11 2.367
ODR4 odr-4 GPCR localization factor homolog 2.34976
APTX aprataxin 2.34858
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.34735
ZNHIT3 zinc finger, HIT-type containing 3 2.34418
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.34014
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.3187
TCEAL4 transcription elongation factor A (SII)-like 4 2.30396
BCAS3 breast carcinoma amplified sequence 3 2.28366
C1GALT1C1 C1GALT1-specific chaperone 1 2.277
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.26881
INTS12 integrator complex subunit 12 2.25066
CISD1 CDGSH iron sulfur domain 1 2.24762
HACD1 3-hydroxyacyl-CoA dehydratase 1 2.24185
COQ8A coenzyme Q8A 2.22814
DUX4 double homeobox 4 2.21364
STEAP3 STEAP family member 3, metalloreductase 2.20766
MICU2 mitochondrial calcium uptake 2 2.19954
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.19441
IGBP1 immunoglobulin (CD79A) binding protein 1 2.17315
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.17269
UBL3 ubiquitin-like 3 2.17089
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.16905
KMT5B lysine methyltransferase 5B 2.15625
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.13961
GLB1 galactosidase, beta 1 2.10758
GET1 guided entry of tail-anchored proteins factor 1 2.10637
TMEM50A transmembrane protein 50A 2.106
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.10584
BCAS2 breast carcinoma amplified sequence 2 2.09761
BCL7B B-cell CLL/lymphoma 7B 2.09139
SFTPB surfactant protein B 2.08375
ATP5MC1 ATP synthase membrane subunit c locus 1 2.06907
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.03599
OLFML2B olfactomedin-like 2B 2.03341
USF2 upstream transcription factor 2, c-fos interacting 2.02649
INTS5 integrator complex subunit 5 2.02529
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.02362
NPC2 Niemann-Pick disease, type C2 2.01547
THEM6 thioesterase superfamily member 6 2.01089
WASHC3 WASH complex subunit 3 2.00671
SLC46A3 solute carrier family 46, member 3 2.0049

decreased expression

Symbol Name Standardized Value
ANXA3 annexin A3 -7.43464
S100A8 S100 calcium binding protein A8 -5.66316
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -5.09147
KRT7 keratin 7, type II -4.54401
RND3 Rho family GTPase 3 -4.44222
NCK2 NCK adaptor protein 2 -3.25198
HSF2BP heat shock transcription factor 2 binding protein -2.97539
IFNAR1 interferon (alpha, beta and omega) receptor 1 -2.80244
VIM vimentin -2.77922
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.7729
CREB5 cAMP responsive element binding protein 5 -2.75502
CDH18 cadherin 18, type 2 -2.74144
CSRP2 cysteine and glycine-rich protein 2 -2.7141
C18ORF25 chromosome 18 open reading frame 25 -2.69864
EIF5A2 eukaryotic translation initiation factor 5A2 -2.68249
MTMR12 myotubularin related protein 12 -2.66771
S1PR1 sphingosine-1-phosphate receptor 1 -2.54706
GRB7 growth factor receptor-bound protein 7 -2.53305
NTF3 neurotrophin 3 -2.52741
ALX4 ALX homeobox 4 -2.52364
KCTD20 potassium channel tetramerization domain containing 20 -2.52101
PRTN3 proteinase 3 -2.4859
PDE5A phosphodiesterase 5A, cGMP-specific -2.47349
UBA6 ubiquitin-like modifier activating enzyme 6 -2.47251
KMT2D lysine (K)-specific methyltransferase 2D -2.46841
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -2.4639
KLF3 Kruppel-like factor 3 (basic) -2.45239
KLF1 Kruppel-like factor 1 (erythroid) -2.44612
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 -2.44002
CATSPERB catsper channel auxiliary subunit beta -2.43893
CD24 CD24 molecule -2.43587
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.43431
CLDN16 claudin 16 -2.43103
GSDMB gasdermin B -2.41443
MMP10 matrix metallopeptidase 10 -2.41213
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.39792
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.3953
ZFHX4 zinc finger homeobox 4 -2.39308
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.38432
SCGB1D2 secretoglobin, family 1D, member 2 -2.38269
SLITRK3 SLIT and NTRK-like family, member 3 -2.38116
SIRPA signal-regulatory protein alpha -2.38106
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.378
MDM4 MDM4, p53 regulator -2.3729
CALB2 calbindin 2 -2.36534
ANG angiogenin, ribonuclease, RNase A family, 5 -2.35864
NEK11 NIMA-related kinase 11 -2.35597
FOXE3 forkhead box E3 -2.3515
CDR2L cerebellar degeneration-related protein 2-like -2.34394
DRC11 dynein regulatory complex subunit 11 -2.34225
KITLG KIT ligand -2.33776
RNASE4 ribonuclease, RNase A family, 4 -2.33195
BTC betacellulin -2.33093
TEF thyrotrophic embryonic factor -2.33054
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.32786
BTNL2 butyrophilin-like 2 -2.31841
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -2.31294
FKBP4 FK506 binding protein 4, 59kDa -2.31292
ETV3 ets variant 3 -2.30993
LATS1 large tumor suppressor kinase 1 -2.30962
AHDC1 AT hook, DNA binding motif, containing 1 -2.30152
ADAMTSL3 ADAMTS-like 3 -2.29725
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) -2.29311
GDAP1 ganglioside induced differentiation associated protein 1 -2.2902
MEIS2 Meis homeobox 2 -2.28415
PSG6 pregnancy specific beta-1-glycoprotein 6 -2.28171
KLF15 Kruppel-like factor 15 -2.26907
KRT12 keratin 12, type I -2.2674
ZNF550 zinc finger protein 550 -2.26657
SNAP23 synaptosomal-associated protein, 23kDa -2.26583
TGFBR1 transforming growth factor, beta receptor 1 -2.26488
OXTR oxytocin receptor -2.26305
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.24968
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.24883
SCGB2A2 secretoglobin, family 2A, member 2 -2.2485
MYCT1 myc target 1 -2.24715
FPGT-TNNI3K FPGT-TNNI3K readthrough -2.24547
PSG5 pregnancy specific beta-1-glycoprotein 5 -2.2431
IL2 interleukin 2 -2.23916
ZNF334 zinc finger protein 334 -2.23788
ZXDB zinc finger, X-linked, duplicated B -2.23756
KRT23 keratin 23, type I -2.23717
MYO15A myosin XVA -2.23617
ADAM11 ADAM metallopeptidase domain 11 -2.2352
GPR50 G protein-coupled receptor 50 -2.23051
LCOR ligand dependent nuclear receptor corepressor -2.22998
MAPK10 mitogen-activated protein kinase 10 -2.22789
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) -2.22776
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.22655
BET1L Bet1 golgi vesicular membrane trafficking protein-like -2.22437
PCDHB1 protocadherin beta 1 -2.2229
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 -2.22041
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.22026
TTC26 tetratricopeptide repeat domain 26 -2.21934
ZNF254 zinc finger protein 254 -2.21346
EXT1 exostosin glycosyltransferase 1 -2.21024
ZNF780A zinc finger protein 780A -2.21
SCN2A sodium channel, voltage gated, type II alpha subunit -2.20787
PDCD1LG2 programmed cell death 1 ligand 2 -2.20226
ELANE elastase, neutrophil expressed -2.20203
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.19665
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.19387
POU4F3 POU class 4 homeobox 3 -2.1926
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.19248
PARD6B par-6 family cell polarity regulator beta -2.19001
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.18376
GK2 glycerol kinase 2 -2.17922
CMA1 chymase 1, mast cell -2.17601
AOX1 aldehyde oxidase 1 -2.17414
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -2.16821
OCM2 oncomodulin 2 -2.16793
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.16597
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.16585
BMX BMX non-receptor tyrosine kinase -2.16434
EDC3 enhancer of mRNA decapping 3 -2.16233
PRDM16 PR domain containing 16 -2.16201
POU2F3 POU class 2 homeobox 3 -2.16161
ORAI2 ORAI calcium release-activated calcium modulator 2 -2.15825
CCND2 cyclin D2 -2.15642
WNT7A wingless-type MMTV integration site family, member 7A -2.15641
ANGPT4 angiopoietin 4 -2.15632
SPATA31C1 SPATA31 subfamily C, member 1 -2.1545
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.15435
RIMS1 regulating synaptic membrane exocytosis 1 -2.15313
MT2A metallothionein 2A -2.15304
MYEF2 myelin expression factor 2 -2.15036
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.14805
MTERF4 mitochondrial transcription termination factor 4 -2.13837
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.13786
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.13775
SCGB2A1 secretoglobin, family 2A, member 1 -2.13069
RYR3 ryanodine receptor 3 -2.12775
ZNF549 zinc finger protein 549 -2.12531
CCNK cyclin K -2.12338
FBXL7 F-box and leucine-rich repeat protein 7 -2.12139
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.12022
ZNF132 zinc finger protein 132 -2.12013
DGKE diacylglycerol kinase, epsilon 64kDa -2.11813
TNN tenascin N -2.11763
ZFAND3 zinc finger, AN1-type domain 3 -2.11746
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.11187
TKTL1 transketolase-like 1 -2.11153
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.10658
HNF4G hepatocyte nuclear factor 4, gamma -2.10528
MCFD2 multiple coagulation factor deficiency 2 -2.10412
PHAF1 phagosome assembly factor 1 -2.10393
LMTK2 lemur tyrosine kinase 2 -2.10342
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -2.10004
BRSK2 BR serine/threonine kinase 2 -2.09966
AMBP alpha-1-microglobulin/bikunin precursor -2.09923
PSG3 pregnancy specific beta-1-glycoprotein 3 -2.09912
AICDA activation-induced cytidine deaminase -2.09807
ABLIM1 actin binding LIM protein 1 -2.09683
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.09552
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.09552
KLK15 kallikrein-related peptidase 15 -2.09533
RLBP1 retinaldehyde binding protein 1 -2.09531
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -2.09489
SRY sex determining region Y -2.09267
KLHL4 kelch-like family member 4 -2.08944
KIAA0408 KIAA0408 -2.0869
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.08582
TRHDE thyrotropin-releasing hormone degrading enzyme -2.08402
CASP2 caspase 2, apoptosis-related cysteine peptidase -2.0838
AFDN afadin, adherens junction formation factor -2.08246
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.08127
ZNF471 zinc finger protein 471 -2.08039
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.08029
IGSF1 immunoglobulin superfamily, member 1 -2.07941
ZNF675 zinc finger protein 675 -2.07621
FEZF2 FEZ family zinc finger 2 -2.07489
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.07419
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.07379
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.07168
KLHL1 kelch-like family member 1 -2.0677
FGF18 fibroblast growth factor 18 -2.06543
PAGE1 P antigen family, member 1 (prostate associated) -2.0653
HOXD12 homeobox D12 -2.06383
POU1F1 POU class 1 homeobox 1 -2.06325
LYZL6 lysozyme-like 6 -2.06097
ZNF280B zinc finger protein 280B -2.05843
TRIM46 tripartite motif containing 46 -2.05828
WNT1 wingless-type MMTV integration site family, member 1 -2.0572
GPR63 G protein-coupled receptor 63 -2.05597
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.05505
ZNF749 zinc finger protein 749 -2.05484
NLRP1 NLR family, pyrin domain containing 1 -2.05336
RASAL1 RAS protein activator like 1 (GAP1 like) -2.05276
RHD Rh blood group, D antigen -2.05252
ARL4C ADP-ribosylation factor-like 4C -2.05204
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -2.05068
TBC1D22B TBC1 domain family, member 22B -2.05038
ST7L suppression of tumorigenicity 7 like -2.05018
ALAS1 5'-aminolevulinate synthase 1 -2.04945
ARSJ arylsulfatase family, member J -2.049
TLL1 tolloid-like 1 -2.04812
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.04774
GPATCH2L G patch domain containing 2-like -2.04709
CNGA3 cyclic nucleotide gated channel alpha 3 -2.04707
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 -2.0461
POC1B-GALNT4 POC1B-GALNT4 readthrough -2.04585
MYH15 myosin, heavy chain 15 -2.04466
LPXN leupaxin -2.04453
BTG4 B-cell translocation gene 4 -2.04157
TEX13B testis expressed 13B -2.03939
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.03869
LOC100652777 group 10 secretory phospholipase A2-like -2.03594
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.03494
BFSP1 beaded filament structural protein 1, filensin -2.03346
PDE12 phosphodiesterase 12 -2.03123
CDCP1 CUB domain containing protein 1 -2.03001
OPRK1 opioid receptor, kappa 1 -2.02972
ZNF343 zinc finger protein 343 -2.02864
ASGR2 asialoglycoprotein receptor 2 -2.02844
RBP4 retinol binding protein 4, plasma -2.02782
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.02766
STMN4 stathmin-like 4 -2.02714
PACC1 proton activated chloride channel 1 -2.02708
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.0265
KRT32 keratin 32, type I -2.02594
TAPT1 transmembrane anterior posterior transformation 1 -2.02523
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.02465
PLA2R1 phospholipase A2 receptor 1, 180kDa -2.02395
SIX3 SIX homeobox 3 -2.02145
H2BC6 H2B clustered histone 6 -2.02121
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.02018
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.02005
GRM7 glutamate receptor, metabotropic 7 -2.01862
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 -2.01815
ARMCX4 armadillo repeat containing, X-linked 4 -2.01812
HGD homogentisate 1,2-dioxygenase -2.01735
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.01729
ZNF268 zinc finger protein 268 -2.01663
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -2.01538
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 -2.01512
FGB fibrinogen beta chain -2.01501
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.01475
TRIM5 tripartite motif containing 5 -2.01286
THRB thyroid hormone receptor, beta -2.0126
ATXN3L ataxin 3-like -2.01227
WNT16 wingless-type MMTV integration site family, member 16 -2.01198
INSRR insulin receptor-related receptor -2.01136
TSPAN2 tetraspanin 2 -2.01127
THBS2 thrombospondin 2 -2.01114
AGRP agouti related neuropeptide -2.01099
HMGA1 high mobility group AT-hook 1 -2.01051
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.0096
ND5 NADH dehydrogenase subunit 5 -2.00854
ZFP2 ZFP2 zinc finger protein -2.00692
KCTD14 potassium channel tetramerization domain containing 14 -2.0069
CDY1 chromodomain protein, Y-linked, 1 -2.00636
CEP97 centrosomal protein 97kDa -2.00606
PRDM10 PR domain containing 10 -2.00531
TES testin LIM domain protein -2.00456
MAP3K7CL MAP3K7 C-terminal like -2.00432
WRN Werner syndrome, RecQ helicase-like -2.0027
BCO1 beta-carotene oxygenase 1 -2.00142
SEC14L4 SEC14-like 4 (S. cerevisiae) -2.00021