CRCGN015_MCF10A_48H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-[4-(5-nitro-2-furyl)-2-thiazo?lyl]formamide 98.33 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN015_MCF10A_48H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.81953
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 3.06497
SIRT3 sirtuin 3 2.90066
FKBP14 FK506 binding protein 14, 22 kDa 2.88216
ARMCX2 armadillo repeat containing, X-linked 2 2.63319
AMDHD2 amidohydrolase domain containing 2 2.47851
LOC102724560 cystathionine beta-synthase 2.4638
SPEF1 sperm flagellar 1 2.43904
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.43821
ZNF688 zinc finger protein 688 2.41608
B9D1 B9 protein domain 1 2.41038
GSDMD gasdermin D 2.40842
PNPLA6 patatin-like phospholipase domain containing 6 2.4046
IL10RA interleukin 10 receptor, alpha 2.39311
DNAH6 dynein, axonemal, heavy chain 6 2.35106
FPGS folylpolyglutamate synthase 2.33726
GARS1 glycyl-tRNA synthetase 1 2.33442
TTC38 tetratricopeptide repeat domain 38 2.3338
TYK2 tyrosine kinase 2 2.3338
NEK11 NIMA-related kinase 11 2.33187
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.33053
MAP1S microtubule-associated protein 1S 2.32168
STRN4 striatin, calmodulin binding protein 4 2.30934
FGF6 fibroblast growth factor 6 2.29528
BZW2 basic leucine zipper and W2 domains 2 2.29282
ACVRL1 activin A receptor type II-like 1 2.27968
SCTR secretin receptor 2.27357
CRY2 cryptochrome circadian clock 2 2.27011
WIF1 WNT inhibitory factor 1 2.26968
ZNF358 zinc finger protein 358 2.2686
DTX2 deltex 2, E3 ubiquitin ligase 2.263
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.24741
ORAI3 ORAI calcium release-activated calcium modulator 3 2.2293
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 2.22618
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.21645
MAPK12 mitogen-activated protein kinase 12 2.21199
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.20971
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 2.20592
RGS14 regulator of G-protein signaling 14 2.17174
HMGN3 high mobility group nucleosomal binding domain 3 2.16681
ADORA3 adenosine A3 receptor 2.14576
NT5DC2 5'-nucleotidase domain containing 2 2.12929
ENG endoglin 2.12411
NOD1 nucleotide-binding oligomerization domain containing 1 2.11403
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.1075
DRP2 dystrophin related protein 2 2.10744
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.09985
EFHC1 EF-hand domain (C-terminal) containing 1 2.08469
FTO fat mass and obesity associated 2.08466
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.0828
CRYM crystallin, mu 2.0823
CNTFR ciliary neurotrophic factor receptor 2.07779
NBEAL2 neurobeachin-like 2 2.06554
OSBPL10 oxysterol binding protein-like 10 2.0613
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.05911
PNKP polynucleotide kinase 3'-phosphatase 2.05647
HAMP hepcidin antimicrobial peptide 2.05462
CLTC clathrin, heavy chain (Hc) 2.05349
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.05145
IPO13 importin 13 2.05105
LRRC32 leucine rich repeat containing 32 2.05064
PRKD2 protein kinase D2 2.04644
ARHGAP24 Rho GTPase activating protein 24 2.04473
TBC1D10C TBC1 domain family, member 10C 2.04174
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.04057
ZNF580 zinc finger protein 580 2.0401
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.04003
MYF6 myogenic factor 6 (herculin) 2.03211
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.03184
TMEM94 transmembrane protein 94 2.02595
WDR19 WD repeat domain 19 2.02579
KLK5 kallikrein-related peptidase 5 2.0232
TOR4A torsin family 4, member A 2.02025
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.01977
SH3GL1 SH3-domain GRB2-like 1 2.01918
GADD45A growth arrest and DNA-damage-inducible, alpha 2.01748
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.01637
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.01133
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 2.00193

decreased expression

Symbol Name Standardized Value
BIRC2 baculoviral IAP repeat containing 2 -3.9718
PGAM4 phosphoglycerate mutase family member 4 -3.8679
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.3532
RXYLT1 ribitol xylosyltransferase 1 -3.16018
ENOPH1 enolase-phosphatase 1 -2.78795
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.77204
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.61868
ZNF184 zinc finger protein 184 -2.6142
FASTKD5 FAST kinase domains 5 -2.51773
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.47535
TGFBI transforming growth factor, beta-induced, 68kDa -2.46523
ZNF443 zinc finger protein 443 -2.40009
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.39829
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.38015
CREG1 cellular repressor of E1A-stimulated genes 1 -2.37456
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.37033
FAM13B family with sequence similarity 13, member B -2.33465
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -2.3276
FBXO7 F-box protein 7 -2.29544
IGFBP7 insulin-like growth factor binding protein 7 -2.2764
LYST lysosomal trafficking regulator -2.25413
PRRC1 proline-rich coiled-coil 1 -2.24603
YAP1 Yes-associated protein 1 -2.24181
ATG3 autophagy related 3 -2.21215
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.20405
MSMO1 methylsterol monooxygenase 1 -2.18052
SLC35A5 solute carrier family 35, member A5 -2.13965
RRAGD Ras-related GTP binding D -2.13606
NPTN neuroplastin -2.10905
ZEB2 zinc finger E-box binding homeobox 2 -2.10229
TRIM27 tripartite motif containing 27 -2.09792
MCUR1 mitochondrial calcium uniporter regulator 1 -2.09425
BAG1 BCL2-associated athanogene -2.09194
H2AZ1 H2A.Z variant histone 1 -2.07242
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.07228
RLF rearranged L-myc fusion -2.07043
LCMT2 leucine carboxyl methyltransferase 2 -2.06459
FXYD3 FXYD domain containing ion transport regulator 3 -2.0581
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.03839
JARID2 jumonji, AT rich interactive domain 2 -2.03445
SPPL2A signal peptide peptidase like 2A -2.01403
ARL14 ADP-ribosylation factor-like 14 -2.00995
CST3 cystatin C -2.00088