CRCGN015_MCF10A_48H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 10.77 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_MCF10A_48H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 4.687
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.64647
PRR7 proline rich 7 (synaptic) 4.47578
MAP2K5 mitogen-activated protein kinase kinase 5 2.93433
UVRAG UV radiation resistance associated 2.69994
CXCL5 chemokine (C-X-C motif) ligand 5 2.5158
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.51552
PCDH8 protocadherin 8 2.34021
ACSS3 acyl-CoA synthetase short-chain family member 3 2.32389
PKN1 protein kinase N1 2.29925
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.19947
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.15252
INTS8 integrator complex subunit 8 2.12099
CLSTN2 calsyntenin 2 2.08213
FXYD7 FXYD domain containing ion transport regulator 7 2.02786
F12 coagulation factor XII (Hageman factor) 2.02173

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.99025
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.8865
OAT ornithine aminotransferase -4.27275
MACF1 microtubule-actin crosslinking factor 1 -3.34051
HEATR1 HEAT repeat containing 1 -2.90208
PDLIM1 PDZ and LIM domain 1 -2.84807
ZMIZ1 zinc finger, MIZ-type containing 1 -2.76942
TM9SF3 transmembrane 9 superfamily member 3 -2.76734
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.27599
CD24 CD24 molecule -2.17705
RPIA ribose 5-phosphate isomerase A -2.16063
MSMO1 methylsterol monooxygenase 1 -2.14201
ZIM3 zinc finger, imprinted 3 -2.09827