CRCGN015_MCF10A_48H:B11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 33.45 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

204 genes differentially expressed following the CRCGN015_MCF10A_48H:B11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.20956
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 4.43185
IER3 immediate early response 3 3.73952
PNKP polynucleotide kinase 3'-phosphatase 3.57947
CCP110 centriolar coiled coil protein 110kDa 3.27769
IL1A interleukin 1, alpha 3.04489
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.96439
KDM5A lysine (K)-specific demethylase 5A 2.93304
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.83884
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.82191
PRH1 proline-rich protein HaeIII subfamily 1 2.68315
KCTD5 potassium channel tetramerization domain containing 5 2.67361
TLCD3A TLC domain containing 3A 2.67202
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.66753
AMDHD2 amidohydrolase domain containing 2 2.66615
GLRX glutaredoxin (thioltransferase) 2.65152
STATH statherin 2.64566
VAT1 vesicle amine transport 1 2.60439
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.58771
KRT24 keratin 24, type I 2.57155
CRCT1 cysteine-rich C-terminal 1 2.56565
SQSTM1 sequestosome 1 2.56341
HCFC2 host cell factor C2 2.55214
UPP1 uridine phosphorylase 1 2.5493
MUC7 mucin 7, secreted 2.51796
GCC2 GRIP and coiled-coil domain containing 2 2.51525
WDR47 WD repeat domain 47 2.50869
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.4962
PPARG peroxisome proliferator-activated receptor gamma 2.47849
TSPAN13 tetraspanin 13 2.47153
RAP1GAP2 RAP1 GTPase activating protein 2 2.47148
IFI35 interferon-induced protein 35 2.46855
DUSP5 dual specificity phosphatase 5 2.4674
TMEM40 transmembrane protein 40 2.43903
GPX7 glutathione peroxidase 7 2.41691
WDR44 WD repeat domain 44 2.41469
FAM131A family with sequence similarity 131, member A 2.41184
PRSS3 protease, serine, 3 2.40763
IL13RA2 interleukin 13 receptor, alpha 2 2.39951
DYNLT3 dynein, light chain, Tctex-type 3 2.39671
CTSE cathepsin E 2.38949
PYGB phosphorylase, glycogen; brain 2.38308
LMBR1L limb development membrane protein 1-like 2.34952
IL22RA1 interleukin 22 receptor, alpha 1 2.34765
GALC galactosylceramidase 2.34414
LOC124907782 dual specificity protein phosphatase 22 2.28809
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.28389
CGB8 chorionic gonadotropin, beta polypeptide 8 2.27755
SAMD9 sterile alpha motif domain containing 9 2.2697
GAK cyclin G associated kinase 2.26886
KRT34 keratin 34, type I 2.24605
TXNRD1 thioredoxin reductase 1 2.24321
KIAA0232 KIAA0232 2.24243
CTSL cathepsin L 2.24112
TRIP12 thyroid hormone receptor interactor 12 2.23613
SLC35F5 solute carrier family 35, member F5 2.23068
SLC35F6 solute carrier family 35, member F6 2.22676
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.21354
CALCOCO1 calcium binding and coiled-coil domain 1 2.20796
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.20785
NRIP1 nuclear receptor interacting protein 1 2.20717
CHPF2 chondroitin polymerizing factor 2 2.18606
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.18315
HBEGF heparin-binding EGF-like growth factor 2.17496
HMGA2 high mobility group AT-hook 2 2.17353
PNMA8A PNMA family member 8A 2.16597
CCDC93 coiled-coil domain containing 93 2.14843
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.14422
COPZ2 coatomer protein complex, subunit zeta 2 2.14409
FHL2 four and a half LIM domains 2 2.14288
WNK1 WNK lysine deficient protein kinase 1 2.14126
MGLL monoglyceride lipase 2.14071
NECTIN4 nectin cell adhesion molecule 4 2.1388
TIMP2 TIMP metallopeptidase inhibitor 2 2.13868
ZFP36 ZFP36 ring finger protein 2.13132
PLTP phospholipid transfer protein 2.1273
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.1257
CDHR2 cadherin-related family member 2 2.1256
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.11588
GSK3B glycogen synthase kinase 3 beta 2.102
PTK6 protein tyrosine kinase 6 2.09795
SPON2 spondin 2, extracellular matrix protein 2.09049
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.08483
ARL14 ADP-ribosylation factor-like 14 2.08287
GARS1 glycyl-tRNA synthetase 1 2.07686
NDN necdin, melanoma antigen (MAGE) family member 2.07659
FOSL1 FOS-like antigen 1 2.0765
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.07489
HTN1 histatin 1 2.07166
RGS2 regulator of G-protein signaling 2 2.07126
PLK3 polo-like kinase 3 2.06852
GALT galactose-1-phosphate uridylyltransferase 2.05416
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.05166
FMOD fibromodulin 2.04761
KIF16B kinesin family member 16B 2.04513
TBC1D19 TBC1 domain family, member 19 2.04404
ZMYM2 zinc finger, MYM-type 2 2.04267
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.04207
PLAUR plasminogen activator, urokinase receptor 2.03862
SMAGP small cell adhesion glycoprotein 2.035
ZDHHC11B zinc finger, DHHC-type containing 11B 2.03123
CAPN6 calpain 6 2.03036
STEAP1B STEAP family member 1B 2.02703
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.02505
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.02211
MEAK7 MTOR associated protein, eak-7 homolog 2.01891
GABARAPL1 GABA(A) receptor-associated protein like 1 2.01073
LY96 lymphocyte antigen 96 2.00978
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.00824
FKBP11 FK506 binding protein 11, 19 kDa 2.008
WDR19 WD repeat domain 19 2.00166
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.00041

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -6.13966
MSMO1 methylsterol monooxygenase 1 -3.87146
ENOPH1 enolase-phosphatase 1 -3.59208
PLK2 polo-like kinase 2 -3.55983
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.36085
SNX7 sorting nexin 7 -3.32104
CDC20 cell division cycle 20 -3.22538
RBMX RNA binding motif protein, X-linked -3.03424
COG2 component of oligomeric golgi complex 2 -3.02071
CCNB2 cyclin B2 -3.02068
TOP2A topoisomerase (DNA) II alpha 170kDa -3.00241
PUF60 poly-U binding splicing factor 60KDa -2.98416
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.90726
BIRC5 baculoviral IAP repeat containing 5 -2.8982
PLK1 polo-like kinase 1 -2.88359
NGRN neugrin, neurite outgrowth associated -2.73054
CDK1 cyclin-dependent kinase 1 -2.71887
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.66853
ISOC1 isochorismatase domain containing 1 -2.65481
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.64078
CTCF CCCTC-binding factor (zinc finger protein) -2.64013
YME1L1 YME1-like 1 ATPase -2.61408
H2AX H2A.X variant histone -2.58713
DERA deoxyribose-phosphate aldolase (putative) -2.57567
NASP nuclear autoantigenic sperm protein (histone-binding) -2.57169
TRMT5 tRNA methyltransferase 5 -2.53501
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.50088
ASB13 ankyrin repeat and SOCS box containing 13 -2.49626
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.49098
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.43186
SNRPA small nuclear ribonucleoprotein polypeptide A -2.42086
ANKRD28 ankyrin repeat domain 28 -2.42041
PRR15L proline rich 15-like -2.41968
PIMREG PICALM interacting mitotic regulator -2.41783
MELK maternal embryonic leucine zipper kinase -2.41382
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.40713
HMGN2 high mobility group nucleosomal binding domain 2 -2.40515
TMX1 thioredoxin-related transmembrane protein 1 -2.38824
NCK1 NCK adaptor protein 1 -2.36145
MCM7 minichromosome maintenance complex component 7 -2.35796
KIF20A kinesin family member 20A -2.35541
CHMP4B charged multivesicular body protein 4B -2.35459
NUSAP1 nucleolar and spindle associated protein 1 -2.33885
F2R coagulation factor II (thrombin) receptor -2.32754
ADGRA3 adhesion G protein-coupled receptor A3 -2.31289
ADSL adenylosuccinate lyase -2.31096
DEK DEK proto-oncogene -2.30723
H2AZ1 H2A.Z variant histone 1 -2.2948
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.27786
PHF10 PHD finger protein 10 -2.25345
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.2465
CREG1 cellular repressor of E1A-stimulated genes 1 -2.2423
WAC WW domain containing adaptor with coiled-coil -2.24138
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.22803
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.20125
SCAP SREBF chaperone -2.19191
DDIT4 DNA-damage-inducible transcript 4 -2.19154
UBE2C ubiquitin-conjugating enzyme E2C -2.18739
TPX2 TPX2, microtubule-associated -2.17298
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.17121
NEK2 NIMA-related kinase 2 -2.16393
TP53 tumor protein p53 -2.16368
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.15209
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.14578
CCNA2 cyclin A2 -2.14265
RIDA reactive intermediate imine deaminase A homolog -2.13557
SNRPE small nuclear ribonucleoprotein polypeptide E -2.13131
PBK PDZ binding kinase -2.12823
KIF18B kinesin family member 18B -2.11759
PRMT5 protein arginine methyltransferase 5 -2.11041
FADS2 fatty acid desaturase 2 -2.11035
MTPAP mitochondrial poly(A) polymerase -2.08717
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.08394
RAD51C RAD51 paralog C -2.08251
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.07282
KIF14 kinesin family member 14 -2.0725
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.06663
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.06453
LDAH lipid droplet associated hydrolase -2.05461
ANKRD10 ankyrin repeat domain 10 -2.05454
FANCC Fanconi anemia, complementation group C -2.05443
PPID peptidylprolyl isomerase D -2.05076
EXOSC8 exosome component 8 -2.05034
PSRC1 proline/serine-rich coiled-coil 1 -2.02707
MBNL2 muscleblind-like splicing regulator 2 -2.02497
MATR3 matrin 3 -2.02432
SEPHS1 selenophosphate synthetase 1 -2.02302
PDLIM1 PDZ and LIM domain 1 -2.01992
CDKN3 cyclin-dependent kinase inhibitor 3 -2.01958
OIP5 Opa interacting protein 5 -2.01558
ASF1B anti-silencing function 1B histone chaperone -2.01222
MIS12 MIS12 kinetochore complex component -2.00381