CRCGN015_MCF10A_48H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 11.15 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN015_MCF10A_48H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.72751
IER3 immediate early response 3 3.16112
VGLL4 vestigial-like family member 4 2.76914
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.41417
SQSTM1 sequestosome 1 2.38854
LRP10 low density lipoprotein receptor-related protein 10 2.05876
WIF1 WNT inhibitory factor 1 2.05549
GPX3 glutathione peroxidase 3 2.01252

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -4.79303
CD58 CD58 molecule -4.06617
MELK maternal embryonic leucine zipper kinase -2.91396
ANKRD10 ankyrin repeat domain 10 -2.66412
SLC35B1 solute carrier family 35, member B1 -2.49874
DDIT4 DNA-damage-inducible transcript 4 -2.3373
CDC20 cell division cycle 20 -2.28404
MYO19 myosin XIX -2.22347
RABL6 RAB, member RAS oncogene family-like 6 -2.22065
DCK deoxycytidine kinase -2.16147
KIF20A kinesin family member 20A -2.10682
SESN1 sestrin 1 -2.0602
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.05372
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -2.05366
KIF15 kinesin family member 15 -2.04348
MNX1 motor neuron and pancreas homeobox 1 -2.0142
CCNB2 cyclin B2 -2.00681