CRCGN015_MCF10A_48H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hp163 perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN015_MCF10A_48H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.05702
ZNF589 zinc finger protein 589 2.64803
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.52523
EIF4A3 eukaryotic translation initiation factor 4A3 2.281
GLIPR1 GLI pathogenesis-related 1 2.23928
SRRD SRR1 domain containing 2.22458
YAF2 YY1 associated factor 2 2.21527
RRAGA Ras-related GTP binding A 2.15977
FKBP5 FK506 binding protein 5 2.1596
SNUPN snurportin 1 2.1327
DDTL D-dopachrome tautomerase-like 2.12398
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.09996
CHPT1 choline phosphotransferase 1 2.09814
NCLN nicalin 2.08704
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.07292
BAG2 BCL2-associated athanogene 2 2.07169
DCXR dicarbonyl/L-xylulose reductase 2.03747
CABIN1 calcineurin binding protein 1 2.03647
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.02457
CBR3 carbonyl reductase 3 2.00864
SCAF8 SR-related CTD-associated factor 8 2.00381
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.00255

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -6.11178
PDLIM1 PDZ and LIM domain 1 -3.80014
YME1L1 YME1-like 1 ATPase -3.65895
ADI1 acireductone dioxygenase 1 -3.22634
S100A8 S100 calcium binding protein A8 -3.11313
AARS1 alanyl-tRNA synthetase 1 -3.0871
SLC35B1 solute carrier family 35, member B1 -2.90866
RPA3 replication protein A3, 14kDa -2.85902
ABI1 abl-interactor 1 -2.76357
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.71704
PTPRK protein tyrosine phosphatase, receptor type, K -2.61615
KRT14 keratin 14, type I -2.47798
CCNB1 cyclin B1 -2.37493
CXXC4 CXXC finger protein 4 -2.37161
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.35405
VIM vimentin -2.34077
ATG4A autophagy related 4A, cysteine peptidase -2.2065
DNAAF5 dynein, axonemal, assembly factor 5 -2.17602
HEATR1 HEAT repeat containing 1 -2.11235
NOP53 NOP53 ribosome biogenesis factor -2.10067
HEATR6 HEAT repeat containing 6 -2.08114
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.07086
ISOC1 isochorismatase domain containing 1 -2.07067
PCDHGB5 protocadherin gamma subfamily B, 5 -2.06124
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -2.05154
SOX3 SRY (sex determining region Y)-box 3 -2.04529
CUL2 cullin 2 -2.02038
CTNND1 catenin (cadherin-associated protein), delta 1 -2.00104