CRCGN015_MCF10A_48H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenz(a,h)anthracene 98.59 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN015_MCF10A_48H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 5.1525
HBA1 hemoglobin, alpha 1 3.16572
DLK1 delta-like 1 homolog (Drosophila) 3.08635
IL1B interleukin 1, beta 2.59702
RBM15B RNA binding motif protein 15B 2.56191
RIN2 Ras and Rab interactor 2 2.52941
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.46891
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.3374
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.33151
PRKCQ protein kinase C, theta 2.30312
ADAM9 ADAM metallopeptidase domain 9 2.28628
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.26136
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.24852
PMM2 phosphomannomutase 2 2.2461
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.23399
GPATCH1 G patch domain containing 1 2.23285
EPHB2 EPH receptor B2 2.227
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 2.21789
DCSTAMP dendrocyte expressed seven transmembrane protein 2.21582
IL9R interleukin 9 receptor 2.21173
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.20905
SOCS2 suppressor of cytokine signaling 2 2.19889
PPARG peroxisome proliferator-activated receptor gamma 2.19407
VAMP7 vesicle-associated membrane protein 7 2.1896
HBEGF heparin-binding EGF-like growth factor 2.18075
TMEM109 transmembrane protein 109 2.17129
COL11A2 collagen, type XI, alpha 2 2.15763
WDR46 WD repeat domain 46 2.1573
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.14714
CAB39 calcium binding protein 39 2.1414
METTL22 methyltransferase like 22 2.12827
OGN osteoglycin 2.12549
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.12052
DHRS3 dehydrogenase/reductase (SDR family) member 3 2.11121
DDR2 discoidin domain receptor tyrosine kinase 2 2.10402
PEX14 peroxisomal biogenesis factor 14 2.09018
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.08007
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.0765
IL5 interleukin 5 2.07619
FOXF1 forkhead box F1 2.06411
COL8A2 collagen, type VIII, alpha 2 2.06218
FGR FGR proto-oncogene, Src family tyrosine kinase 2.06174
G0S2 G0/G1 switch 2 2.05757
VSTM4 V-set and transmembrane domain containing 4 2.05352
BDKRB2 bradykinin receptor B2 2.05149
JCAD junctional cadherin 5 associated 2.04778
TMEM101 transmembrane protein 101 2.04116
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.03232
TSHR thyroid stimulating hormone receptor 2.03226
PDGFRL platelet-derived growth factor receptor-like 2.02711
AOC3 amine oxidase, copper containing 3 2.02503
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.02254
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.01702
KIAA0319 KIAA0319 2.01317
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.01155
COL14A1 collagen, type XIV, alpha 1 2.00013

decreased expression

Symbol Name Standardized Value
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.72843
ANKRD10 ankyrin repeat domain 10 -3.53635
PLS1 plastin 1 -3.44709
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.18495
SLC35F2 solute carrier family 35, member F2 -3.09209
S100A8 S100 calcium binding protein A8 -3.01215
HSPB1 heat shock 27kDa protein 1 -2.95571
MELK maternal embryonic leucine zipper kinase -2.88735
TXNDC9 thioredoxin domain containing 9 -2.68896
NLRP4 NLR family, pyrin domain containing 4 -2.59267
OXA1L oxidase (cytochrome c) assembly 1-like -2.5892
PLK1 polo-like kinase 1 -2.56839
PUF60 poly-U binding splicing factor 60KDa -2.52126
LTF lactotransferrin -2.42372
KRT7 keratin 7, type II -2.41606
MSMO1 methylsterol monooxygenase 1 -2.39397
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.36327
AKIRIN1 akirin 1 -2.35176
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.34114
AHCY adenosylhomocysteinase -2.31287
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.28733
CHL1 cell adhesion molecule L1-like -2.28512
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.2709
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.2632
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.25223
MRPL12 mitochondrial ribosomal protein L12 -2.2491
ZMAT3 zinc finger, matrin-type 3 -2.23334
RBM39 RNA binding motif protein 39 -2.19107
AHNAK2 AHNAK nucleoprotein 2 -2.15888
ILK integrin-linked kinase -2.13939
UBXN7 UBX domain protein 7 -2.13415
ADGRA3 adhesion G protein-coupled receptor A3 -2.12467
YAF2 YY1 associated factor 2 -2.11314
CLK4 CDC-like kinase 4 -2.10408
PLIN3 perilipin 3 -2.10266
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.10259
ING1 inhibitor of growth family, member 1 -2.09895
LDHA lactate dehydrogenase A -2.07194
FN1 fibronectin 1 -2.07134
VWA1 von Willebrand factor A domain containing 1 -2.07128
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.06859
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.06215
TPST1 tyrosylprotein sulfotransferase 1 -2.06061
COQ8A coenzyme Q8A -2.05337
C1QBP complement component 1, q subcomponent binding protein -2.0523
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.02556
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.01776
TCTA T-cell leukemia translocation altered -2.01113