CRCGN015_MCF10A_48H:B22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 104.84 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

671 genes differentially expressed following the CRCGN015_MCF10A_48H:B22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 5.68494
WIF1 WNT inhibitory factor 1 5.41592
GLRX glutaredoxin (thioltransferase) 5.34202
HBA1 hemoglobin, alpha 1 5.00326
HMGA2 high mobility group AT-hook 2 4.82491
GARS1 glycyl-tRNA synthetase 1 4.82237
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 4.76271
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.4644
AXIN1 axin 1 4.34704
SQSTM1 sequestosome 1 4.33339
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.32081
PYGB phosphorylase, glycogen; brain 4.2272
GDI1 GDP dissociation inhibitor 1 4.22369
AARS1 alanyl-tRNA synthetase 1 4.20474
FAM50A family with sequence similarity 50, member A 4.16198
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.15096
SSH3 slingshot protein phosphatase 3 4.13908
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.1173
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.96384
LAGE3 L antigen family, member 3 3.89998
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3.88151
TALDO1 transaldolase 1 3.86241
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.77157
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.73246
MACF1 microtubule-actin crosslinking factor 1 3.68999
SLC67A1 solute carrier family 67 member 1 3.68711
EGR1 early growth response 1 3.66956
TOMM34 translocase of outer mitochondrial membrane 34 3.65446
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 3.63557
CDPF1 cysteine-rich, DPF motif domain containing 1 3.60885
GPX4 glutathione peroxidase 4 3.56616
PHGDH phosphoglycerate dehydrogenase 3.54776
DUSP6 dual specificity phosphatase 6 3.51849
TTC17 tetratricopeptide repeat domain 17 3.46222
MUTYH mutY homolog 3.45872
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.35984
FOSL1 FOS-like antigen 1 3.35056
HDLBP high density lipoprotein binding protein 3.32971
G0S2 G0/G1 switch 2 3.3232
GMPPA GDP-mannose pyrophosphorylase A 3.32167
ACADVL acyl-CoA dehydrogenase, very long chain 3.31929
TXNRD1 thioredoxin reductase 1 3.30331
C2CD2 C2 calcium-dependent domain containing 2 3.29294
FAM131A family with sequence similarity 131, member A 3.25191
PGAP6 post-GPI attachment to proteins 6 3.24801
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.2451
UPP1 uridine phosphorylase 1 3.24322
ATF4 activating transcription factor 4 3.23489
LGMN legumain 3.17097
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.15129
GDF15 growth differentiation factor 15 3.13792
HTRA1 HtrA serine peptidase 1 3.11353
NME3 NME/NM23 nucleoside diphosphate kinase 3 3.10132
DVL1 dishevelled segment polarity protein 1 3.07478
UBL4A ubiquitin-like 4A 3.0417
TIMP1 TIMP metallopeptidase inhibitor 1 3.03783
CARS1 cysteinyl-tRNA synthetase 1 3.02887
IER3 immediate early response 3 3.017
PORCN porcupine homolog (Drosophila) 3.01318
TAC4 tachykinin 4 (hemokinin) 3.01202
MACROD1 MACRO domain containing 1 3.0109
PLA2G4B phospholipase A2, group IVB (cytosolic) 3.00497
PYCR1 pyrroline-5-carboxylate reductase 1 2.98463
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.97321
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.97316
STXBP2 syntaxin binding protein 2 2.96641
PPARG peroxisome proliferator-activated receptor gamma 2.95483
EMD emerin 2.95379
RPN1 ribophorin I 2.9482
COL6A2 collagen, type VI, alpha 2 2.94227
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.92748
DUSP5 dual specificity phosphatase 5 2.92612
VRK2 vaccinia related kinase 2 2.92229
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.88052
ELOVL1 ELOVL fatty acid elongase 1 2.87584
ADA adenosine deaminase 2.87364
LAD1 ladinin 1 2.84408
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.83969
TWF2 twinfilin actin binding protein 2 2.81734
VAT1 vesicle amine transport 1 2.81412
SDC4 syndecan 4 2.80912
SPHK1 sphingosine kinase 1 2.80642
SPG11 spastic paraplegia 11 (autosomal recessive) 2.7956
HBEGF heparin-binding EGF-like growth factor 2.79029
USP11 ubiquitin specific peptidase 11 2.78516
RAP1GAP RAP1 GTPase activating protein 2.78497
CUL7 cullin 7 2.77979
ITGA10 integrin, alpha 10 2.77975
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.76953
NPDC1 neural proliferation, differentiation and control, 1 2.76245
MAGED4B melanoma antigen family D4B 2.76079
CDK16 cyclin-dependent kinase 16 2.75827
CAMTA2 calmodulin binding transcription activator 2 2.75563
HSPB1 heat shock 27kDa protein 1 2.74972
IL36RN interleukin 36 receptor antagonist 2.73693
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.73677
PSAT1 phosphoserine aminotransferase 1 2.73399
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.72018
GK glycerol kinase 2.71539
EGR3 early growth response 3 2.70331
TRABD TraB domain containing 2.6978
TLCD3A TLC domain containing 3A 2.67625
KRT1 keratin 1, type II 2.6648
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.6498
MZT2A mitotic spindle organizing protein 2A 2.64506
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.64142
STX1A syntaxin 1A (brain) 2.63544
RBP4 retinol binding protein 4, plasma 2.60872
BCAP31 B-cell receptor-associated protein 31 2.59777
NDN necdin, melanoma antigen (MAGE) family member 2.59529
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.58296
SQOR sulfide quinone oxidoreductase 2.58037
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.57974
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.57755
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.57282
ATG4B autophagy related 4B, cysteine peptidase 2.56991
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.56919
MLPH melanophilin 2.56572
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.55502
HHIPL2 HHIP-like 2 2.55021
FNDC4 fibronectin type III domain containing 4 2.54785
PLCD1 phospholipase C, delta 1 2.54776
RIPOR1 RHO family interacting cell polarization regulator 1 2.53778
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.53713
RTL8C retrotransposon Gag like 8C 2.53551
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.53541
S100A12 S100 calcium binding protein A12 2.52729
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 2.52583
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.52332
GALE UDP-galactose-4-epimerase 2.51414
CYB5R2 cytochrome b5 reductase 2 2.5039
GPR153 G protein-coupled receptor 153 2.49142
HMOX1 heme oxygenase 1 2.4911
UPK1A uroplakin 1A 2.48562
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.4782
TSKU tsukushi, small leucine rich proteoglycan 2.46959
MZT2B mitotic spindle organizing protein 2B 2.46118
APOA2 apolipoprotein A-II 2.45039
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.44979
LMTK1 lemur tail kinase 1 2.44814
CXCL2 chemokine (C-X-C motif) ligand 2 2.4385
GPX2 glutathione peroxidase 2 2.43692
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.4329
FAM3A family with sequence similarity 3, member A 2.43127
HEXB hexosaminidase B (beta polypeptide) 2.42937
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.42507
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 2.42399
GDF5 growth differentiation factor 5 2.41963
STAMBP STAM binding protein 2.41841
ATF3 activating transcription factor 3 2.41702
PREB prolactin regulatory element binding 2.41506
CHMP2A charged multivesicular body protein 2A 2.4089
EIPR1 EARP complex and GARP complex interacting protein 1 2.40865
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.39859
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.39573
PKP1 plakophilin 1 2.3892
ACVR1 activin A receptor, type I 2.37915
MBD5 methyl-CpG binding domain protein 5 2.37263
HMGA1 high mobility group AT-hook 1 2.36907
H1-0 H1.0 linker histone 2.36887
ECI1 enoyl-CoA delta isomerase 1 2.36159
GTF2IRD1 GTF2I repeat domain containing 1 2.35833
UBA1 ubiquitin-like modifier activating enzyme 1 2.35635
GLG1 golgi glycoprotein 1 2.3538
IGFBP1 insulin-like growth factor binding protein 1 2.34876
OPLAH 5-oxoprolinase (ATP-hydrolysing) 2.34846
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.34709
PLXNA3 plexin A3 2.34095
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.33966
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.33952
CIRBP cold inducible RNA binding protein 2.33685
MRC2 mannose receptor, C type 2 2.32901
ZMYM2 zinc finger, MYM-type 2 2.32736
RTN4 reticulon 4 2.32625
NPAS2 neuronal PAS domain protein 2 2.32082
MAST4 microtubule associated serine/threonine kinase family member 4 2.31841
PLAUR plasminogen activator, urokinase receptor 2.31473
GMPS guanine monphosphate synthase 2.31421
LIF leukemia inhibitory factor 2.30986
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.30857
NALF2 NALCN channel auxiliary factor 2 2.30577
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.30437
FAM193A family with sequence similarity 193, member A 2.29291
GRK2 G protein-coupled receptor kinase 2 2.29
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 2.28516
FOS FBJ murine osteosarcoma viral oncogene homolog 2.28175
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.27487
GAK cyclin G associated kinase 2.27401
TRIB3 tribbles pseudokinase 3 2.2679
SKIC2 SKI2 subunit of superkiller complex 2.26741
RAB15 RAB15, member RAS oncogene family 2.26441
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.25929
TMEM214 transmembrane protein 214 2.25836
MRPS16 mitochondrial ribosomal protein S16 2.25526
MFGE8 milk fat globule-EGF factor 8 protein 2.24941
COL5A3 collagen, type V, alpha 3 2.24819
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.24795
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.24643
AKR1C3 aldo-keto reductase family 1, member C3 2.24504
PCBP1 poly(rC) binding protein 1 2.23906
ZMIZ1 zinc finger, MIZ-type containing 1 2.23826
ANKRD11 ankyrin repeat domain 11 2.23315
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 2.22974
GNL1 guanine nucleotide binding protein-like 1 2.22944
ANO1 anoctamin 1, calcium activated chloride channel 2.22518
VCAN versican 2.2239
MANBA mannosidase, beta A, lysosomal 2.21914
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.21204
SPRR3 small proline-rich protein 3 2.20956
HLA-A major histocompatibility complex, class I, A 2.20284
TMEM134 transmembrane protein 134 2.1962
LRRC20 leucine rich repeat containing 20 2.19373
OLAH oleoyl-ACP hydrolase 2.1884
VSIG2 V-set and immunoglobulin domain containing 2 2.18806
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.18132
YARS1 tyrosyl-tRNA synthetase 1 2.1803
P4HB prolyl 4-hydroxylase, beta polypeptide 2.17737
INTS11 integrator complex subunit 11 2.17712
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.17655
GSTT1 glutathione S-transferase theta 1 2.17259
RXRA retinoid X receptor, alpha 2.16903
LOC124907782 dual specificity protein phosphatase 22 2.16299
ETFB electron-transfer-flavoprotein, beta polypeptide 2.158
RNF39 ring finger protein 39 2.14675
CCNA1 cyclin A1 2.14272
CRCT1 cysteine-rich C-terminal 1 2.1346
SSR4 signal sequence receptor, delta 2.13122
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.13059
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.12973
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.12453
PLIN2 perilipin 2 2.12319
ZFP36 ZFP36 ring finger protein 2.12278
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.12188
MAPK13 mitogen-activated protein kinase 13 2.1101
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.11009
ZNF692 zinc finger protein 692 2.10791
EFL1 elongation factor like GTPase 1 2.10749
TERF2IP telomeric repeat binding factor 2, interacting protein 2.10733
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.1002
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.09718
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.08911
BMAL2 basic helix-loop-helix ARNT like 2 2.08793
SUN2 Sad1 and UNC84 domain containing 2 2.08753
LARP6 La ribonucleoprotein domain family, member 6 2.08349
PRRX2 paired related homeobox 2 2.08218
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.07554
HAS2 hyaluronan synthase 2 2.0745
HS1BP3 HCLS1 binding protein 3 2.07121
PTK6 protein tyrosine kinase 6 2.07052
TMPRSS11E transmembrane protease, serine 11E 2.06969
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.06827
NLRX1 NLR family member X1 2.0646
ANO10 anoctamin 10 2.0632
KDM7A lysine (K)-specific demethylase 7A 2.06138
GATAD1 GATA zinc finger domain containing 1 2.04849
UPK3A uroplakin 3A 2.04601
NPIPB5 nuclear pore complex interacting protein family, member B5 2.04596
LOC122539214 Zinc finger protein LOC122539214 2.04566
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.03564
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.03532
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.03188
IL4R interleukin 4 receptor 2.02763
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.02655
SLC16A6 solute carrier family 16, member 6 2.024
ATG13 autophagy related 13 2.02044
MAST2 microtubule associated serine/threonine kinase 2 2.01813
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.01697
EFS embryonal Fyn-associated substrate 2.01651
AKR1C1 aldo-keto reductase family 1, member C1 2.01567
NR1D1 nuclear receptor subfamily 1, group D, member 1 2.01517
TNPO3 transportin 3 2.01437
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.01377
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.0066
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.00656
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.00161

decreased expression

Symbol Name Standardized Value
ANXA3 annexin A3 -9.59875
PLK2 polo-like kinase 2 -8.96996
MSMO1 methylsterol monooxygenase 1 -7.44613
PRR15L proline rich 15-like -5.78685
LZTFL1 leucine zipper transcription factor-like 1 -4.47323
TXNDC9 thioredoxin domain containing 9 -4.16126
DIPK1A divergent protein kinase domain 1A -4.01902
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -3.87405
FAM13B family with sequence similarity 13, member B -3.77888
ZNF35 zinc finger protein 35 -3.70073
COG7 component of oligomeric golgi complex 7 -3.6902
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -3.65071
C1QB complement component 1, q subcomponent, B chain -3.5794
CD24 CD24 molecule -3.57601
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.55334
AOPEP aminopeptidase O (putative) -3.53009
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -3.52168
ADRB2 adrenoceptor beta 2, surface -3.49658
ZNF318 zinc finger protein 318 -3.41108
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.40668
FASTKD3 FAST kinase domains 3 -3.4036
MFAP3 microfibrillar-associated protein 3 -3.36224
THAP1 THAP domain containing, apoptosis associated protein 1 -3.33913
SLC25A46 solute carrier family 25, member 46 -3.31259
PEX2 peroxisomal biogenesis factor 2 -3.29187
ZCCHC10 zinc finger, CCHC domain containing 10 -3.25074
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -3.19599
TMEM50A transmembrane protein 50A -3.18572
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.1622
XPA xeroderma pigmentosum, complementation group A -3.15871
ZBTB35 zinc finger and BTB domain containing 35 -3.11101
ASTE1 asteroid homolog 1 (Drosophila) -3.08866
ISCA1 iron-sulfur cluster assembly 1 -3.07698
FBXL2 F-box and leucine-rich repeat protein 2 -3.06931
TGFBR1 transforming growth factor, beta receptor 1 -3.06374
TMEM267 transmembrane protein 267 -3.06183
ACOT9 acyl-CoA thioesterase 9 -3.04857
RABIF RAB interacting factor -3.04793
MIS12 MIS12 kinetochore complex component -3.04784
KIF20A kinesin family member 20A -3.03353
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -3.01952
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.9927
MYNN myoneurin -2.96897
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.96098
REEP5 receptor accessory protein 5 -2.95922
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.95633
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.94025
C1QA complement component 1, q subcomponent, A chain -2.93962
ELOVL6 ELOVL fatty acid elongase 6 -2.92641
ZNF227 zinc finger protein 227 -2.92174
PLS1 plastin 1 -2.91851
DUSP14 dual specificity phosphatase 14 -2.90933
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.89889
MED21 mediator complex subunit 21 -2.88019
SYNJ2BP synaptojanin 2 binding protein -2.87638
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -2.84487
TTC1 tetratricopeptide repeat domain 1 -2.8386
BBS10 Bardet-Biedl syndrome 10 -2.82323
TTI2 TELO2 interacting protein 2 -2.81882
SOCS5 suppressor of cytokine signaling 5 -2.81753
ZNF669 zinc finger protein 669 -2.81446
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.81237
ZNF14 zinc finger protein 14 -2.80666
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.80531
PHACTR4 phosphatase and actin regulator 4 -2.80226
TLR3 toll-like receptor 3 -2.79374
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.79127
MACIR macrophage immunometabolism regulator -2.79109
RBM23 RNA binding motif protein 23 -2.78814
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.78639
SMYD2 SET and MYND domain containing 2 -2.78537
CDC23 cell division cycle 23 -2.78321
H2AZ2 H2A.Z variant histone 2 -2.77486
CRIPT cysteine-rich PDZ-binding protein -2.77262
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.77019
GDE1 glycerophosphodiester phosphodiesterase 1 -2.76977
CD46 CD46 molecule, complement regulatory protein -2.76967
KITLG KIT ligand -2.75729
MAT2B methionine adenosyltransferase II, beta -2.752
NCK1 NCK adaptor protein 1 -2.74666
ZNF557 zinc finger protein 557 -2.74112
NFYB nuclear transcription factor Y, beta -2.73449
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.73258
CDK7 cyclin-dependent kinase 7 -2.73019
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.7267
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.72305
RIC8B RIC8 guanine nucleotide exchange factor B -2.71297
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -2.71058
DCAF6 DDB1 and CUL4 associated factor 6 -2.70667
ATG5 autophagy related 5 -2.70378
PUS7 pseudouridylate synthase 7 (putative) -2.69636
SKP1 S-phase kinase-associated protein 1 -2.69001
TCTA T-cell leukemia translocation altered -2.6807
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.67787
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.67239
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.66686
TCEAL4 transcription elongation factor A (SII)-like 4 -2.66002
TMEM115 transmembrane protein 115 -2.65241
WDR47 WD repeat domain 47 -2.65217
ZDHHC6 zinc finger, DHHC-type containing 6 -2.6443
UNC13B unc-13 homolog B (C. elegans) -2.63695
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.63595
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.62872
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.62636
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.6165
YIPF5 Yip1 domain family, member 5 -2.61628
PDLIM1 PDZ and LIM domain 1 -2.61144
RSU1 Ras suppressor protein 1 -2.60396
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.60354
ARFIP1 ADP-ribosylation factor interacting protein 1 -2.60065
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.59961
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -2.599
GIMAP6 GTPase, IMAP family member 6 -2.5987
DRAM1 DNA-damage regulated autophagy modulator 1 -2.59587
PCDH12 protocadherin 12 -2.59423
CAVIN2 caveolae associated protein 2 -2.5913
PNPO pyridoxamine 5'-phosphate oxidase -2.58629
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.58226
TTC33 tetratricopeptide repeat domain 33 -2.57946
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.5765
LAP3 leucine aminopeptidase 3 -2.57105
EFNB2 ephrin-B2 -2.56464
PAIP1 poly(A) binding protein interacting protein 1 -2.56233
MED7 mediator complex subunit 7 -2.55977
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.55945
TMEM14A transmembrane protein 14A -2.55807
ANOS1 anosmin 1 -2.55492
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.54311
HSBP1 heat shock factor binding protein 1 -2.54219
ZNF443 zinc finger protein 443 -2.53989
NME7 NME/NM23 family member 7 -2.53723
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -2.53497
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.53413
HOXA4 homeobox A4 -2.53393
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.53129
SAP30L SAP30-like -2.53122
TMOD3 tropomodulin 3 (ubiquitous) -2.52249
MOGAT2 monoacylglycerol O-acyltransferase 2 -2.52204
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.52175
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.52129
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.5175
COL4A1 collagen, type IV, alpha 1 -2.51678
CHURC1-FNTB CHURC1-FNTB readthrough -2.51494
ANKRD49 ankyrin repeat domain 49 -2.50691
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -2.50517
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.50185
EPB41L4A erythrocyte membrane protein band 4.1 like 4A -2.50013
SYNPO synaptopodin -2.49629
RUNDC3B RUN domain containing 3B -2.4898
C1GALT1C1 C1GALT1-specific chaperone 1 -2.48486
CDH5 cadherin 5, type 2 (vascular endothelium) -2.48477
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.47829
DSG2 desmoglein 2 -2.47821
ZNF197 zinc finger protein 197 -2.47558
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -2.47407
HSPA14 heat shock 70kDa protein 14 -2.47399
GFI1 growth factor independent 1 transcription repressor -2.46976
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.46797
SMG8 SMG8 nonsense mediated mRNA decay factor -2.46516
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.46501
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.4631
MEIS1 Meis homeobox 1 -2.46299
FBXO34 F-box protein 34 -2.45768
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.45423
SESN1 sestrin 1 -2.45114
UTP25 UTP25 small subunit processome component -2.44893
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.44437
RAB30 RAB30, member RAS oncogene family -2.43901
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -2.43731
PANK3 pantothenate kinase 3 -2.42677
FANCF Fanconi anemia, complementation group F -2.42676
UXT ubiquitously-expressed, prefoldin-like chaperone -2.42532
ADI1 acireductone dioxygenase 1 -2.42331
RXYLT1 ribitol xylosyltransferase 1 -2.4231
TMEM131L transmembrane 131 like -2.42118
TMEM184C transmembrane protein 184C -2.41927
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.41886
LIMK2 LIM domain kinase 2 -2.4169
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.41367
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) -2.41041
NR2F2 nuclear receptor subfamily 2, group F, member 2 -2.4065
STOM stomatin -2.40547
CSNK1G3 casein kinase 1, gamma 3 -2.40331
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.39916
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.39838
SRI sorcin -2.39056
GIN1 gypsy retrotransposon integrase 1 -2.38751
FXN frataxin -2.38101
SPDL1 spindle apparatus coiled-coil protein 1 -2.37626
KIF11 kinesin family member 11 -2.3737
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.36558
SPON1 spondin 1, extracellular matrix protein -2.36402
PIERCE1 piercer of microtubule wall 1 -2.36391
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.36214
SMNDC1 survival motor neuron domain containing 1 -2.36211
CCDC186 coiled-coil domain containing 186 -2.35951
COMMD10 COMM domain containing 10 -2.3571
KRT81 keratin 81, type II -2.35511
LYRM2 LYR motif containing 2 -2.35414
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.35365
WDR3 WD repeat domain 3 -2.35202
STMN1 stathmin 1 -2.3495
ZNF510 zinc finger protein 510 -2.34749
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.34539
MRPS17 mitochondrial ribosomal protein S17 -2.34447
GTF2B general transcription factor IIB -2.34285
TOR1AIP2 torsin A interacting protein 2 -2.34221
IPO8 importin 8 -2.3415
IFT38 intraflagellar transport 38 -2.33989
FJX1 four jointed box 1 (Drosophila) -2.33639
SRSF3 serine/arginine-rich splicing factor 3 -2.32898
RNF38 ring finger protein 38 -2.32879
SINHCAF SIN3-HDAC complex associated factor -2.32705
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.3254
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.32293
ITGB8 integrin, beta 8 -2.32225
NOL8 nucleolar protein 8 -2.31834
KDM3B lysine (K)-specific demethylase 3B -2.31811
NOAZFP nucleolar atypical zinc finger -2.31481
TRIP13 thyroid hormone receptor interactor 13 -2.3116
ANKRD10 ankyrin repeat domain 10 -2.30324
CLIC4 chloride intracellular channel 4 -2.30163
TASP1 taspase, threonine aspartase, 1 -2.30141
CCNB2 cyclin B2 -2.29963
UBA5 ubiquitin-like modifier activating enzyme 5 -2.29778
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.29422
STMN2 stathmin 2 -2.29392
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.28848
NUP160 nucleoporin 160kDa -2.28706
MCMBP minichromosome maintenance complex binding protein -2.28486
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.2811
PBK PDZ binding kinase -2.28007
ZNF45 zinc finger protein 45 -2.27963
MRPS14 mitochondrial ribosomal protein S14 -2.27737
ZNF544 zinc finger protein 544 -2.27655
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.27372
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.27354
NEFM neurofilament, medium polypeptide -2.27167
RGS2 regulator of G-protein signaling 2 -2.27084
CELF2 CUGBP, Elav-like family member 2 -2.27001
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.26984
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.26926
STS steroid sulfatase (microsomal), isozyme S -2.26816
EZR ezrin -2.26768
TWF1 twinfilin actin binding protein 1 -2.26592
ZNF33B zinc finger protein 33B -2.26567
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.26503
REEP1 receptor accessory protein 1 -2.26113
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.25734
TNIP1 TNFAIP3 interacting protein 1 -2.25713
UBE2B ubiquitin-conjugating enzyme E2B -2.25541
FBXO3 F-box protein 3 -2.25517
HCCS holocytochrome c synthase -2.25399
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.25388
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.2538
IL18 interleukin 18 -2.25233
STOML2 stomatin (EPB72)-like 2 -2.25125
CPAP centrosome assembly and centriole elongation protein -2.24605
ADGRE5 adhesion G protein-coupled receptor E5 -2.2448
LAPTM4B lysosomal protein transmembrane 4 beta -2.24331
TRIM22 tripartite motif containing 22 -2.24001
DEXI Dexi homolog (mouse) -2.23871
DNAAF2 dynein, axonemal, assembly factor 2 -2.23855
NUBP2 nucleotide binding protein 2 -2.23387
EGFL8 EGF-like-domain, multiple 8 -2.23323
HOXA5 homeobox A5 -2.23201
CEMIP2 cell migration inducing hyaluronidase 2 -2.22968
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -2.22838
DCTN5 dynactin 5 (p25) -2.22678
NOP16 NOP16 nucleolar protein -2.22574
NUP133 nucleoporin 133kDa -2.22564
PYDC1 PYD (pyrin domain) containing 1 -2.22463
MICB MHC class I polypeptide-related sequence B -2.22365
MED31 mediator complex subunit 31 -2.21627
PDCL phosducin-like -2.21607
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.21047
BIRC5 baculoviral IAP repeat containing 5 -2.21046
TWNK twinkle mtDNA helicase -2.20751
ZNF134 zinc finger protein 134 -2.20497
GRWD1 glutamate-rich WD repeat containing 1 -2.20177
ZNF322 zinc finger protein 322 -2.19977
CCDC6 coiled-coil domain containing 6 -2.19929
SAR1B secretion associated, Ras related GTPase 1B -2.19771
RFC3 replication factor C (activator 1) 3, 38kDa -2.19631
DCK deoxycytidine kinase -2.19542
PPP6C protein phosphatase 6, catalytic subunit -2.19309
ZNF180 zinc finger protein 180 -2.19221
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.18997
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.18629
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.18468
ZNF200 zinc finger protein 200 -2.17909
CFAP20 cilia and flagella associated protein 20 -2.17877
ZNF189 zinc finger protein 189 -2.17373
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.16999
STEAP4 STEAP family member 4 -2.16874
MRPL48 mitochondrial ribosomal protein L48 -2.16653
IRF1 interferon regulatory factor 1 -2.16277
FRS2 fibroblast growth factor receptor substrate 2 -2.1621
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -2.15834
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -2.15699
ARMC7 armadillo repeat containing 7 -2.15546
TFB2M transcription factor B2, mitochondrial -2.1509
ZFP30 ZFP30 zinc finger protein -2.14592
CALCRL calcitonin receptor-like -2.14338
ABT1 activator of basal transcription 1 -2.13973
MFSD1 major facilitator superfamily domain containing 1 -2.13954
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.13815
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.13622
ZNF354A zinc finger protein 354A -2.13593
ZNF629 zinc finger protein 629 -2.13399
NEK7 NIMA-related kinase 7 -2.1318
LYRM4 LYR motif containing 4 -2.129
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.1284
AUH AU RNA binding protein/enoyl-CoA hydratase -2.12694
NDNF neuron-derived neurotrophic factor -2.12639
NME5 NME/NM23 family member 5 -2.12084
EMCN endomucin -2.12037
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.12032
GAR1 GAR1 ribonucleoprotein -2.11655
SNX2 sorting nexin 2 -2.11511
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.1148
TMCO1 transmembrane and coiled-coil domains 1 -2.11454
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.11094
BRIX1 BRX1, biogenesis of ribosomes -2.10777
PHACTR1 phosphatase and actin regulator 1 -2.10765
DCTN4 dynactin 4 (p62) -2.10739
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.09928
SYF2 SYF2 pre-mRNA-splicing factor -2.09901
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -2.0987
SETD6 SET domain containing 6 -2.09826
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.09768
EDN1 endothelin 1 -2.09702
IRF8 interferon regulatory factor 8 -2.09364
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.08947
MAB21L1 mab-21-like 1 (C. elegans) -2.08862
RBM48 RNA binding motif protein 48 -2.08859
CREBL2 cAMP responsive element binding protein-like 2 -2.08794
FAM200C family with sequence similarity 200 member C -2.08651
TBK1 TANK-binding kinase 1 -2.08631
EAPP E2F-associated phosphoprotein -2.08592
HMGB3 high mobility group box 3 -2.08418
CCL8 chemokine (C-C motif) ligand 8 -2.0837
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.07908
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.07834
MGAM maltase-glucoamylase -2.07615
PGC progastricsin (pepsinogen C) -2.07446
CTBP2 C-terminal binding protein 2 -2.07389
SOSTDC1 sclerostin domain containing 1 -2.06878
SNRPE small nuclear ribonucleoprotein polypeptide E -2.06789
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.06428
VCX3A variable charge, X-linked 3A -2.0616
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.05986
HHAT hedgehog acyltransferase -2.05944
TATDN2 TatD DNase domain containing 2 -2.05932
ZDHHC3 zinc finger, DHHC-type containing 3 -2.05876
SERF1A small EDRK-rich factor 1A (telomeric) -2.05433
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.05431
HARS1 histidyl-tRNA synthetase 1 -2.05381
CCND1 cyclin D1 -2.05237
PRDX4 peroxiredoxin 4 -2.05233
TSFM Ts translation elongation factor, mitochondrial -2.05169
KIAA0040 KIAA0040 -2.05116
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.05082
HIPK3 homeodomain interacting protein kinase 3 -2.04513
INSIG2 insulin induced gene 2 -2.04377
RESF1 retroelement silencing factor 1 -2.0436
FAR2 fatty acyl CoA reductase 2 -2.04179
TEFM transcription elongation factor, mitochondrial -2.03902
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.03872
ABI1 abl-interactor 1 -2.0376
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.03637
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.03635
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.03542
DAZAP2 DAZ associated protein 2 -2.03528
RAD51C RAD51 paralog C -2.03476
CYCS cytochrome c, somatic -2.0336
METTL18 methyltransferase like 18 -2.03346
NLRP2B NLR family pyrin domain containing 2B -2.0311
DCTPP1 dCTP pyrophosphatase 1 -2.02892
UBE2N ubiquitin-conjugating enzyme E2N -2.02883
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.0266
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -2.02593
RAB27B RAB27B, member RAS oncogene family -2.02524
ARHGAP15 Rho GTPase activating protein 15 -2.02208
SNIP1 Smad nuclear interacting protein 1 -2.02189
ASDURF ASNSD1 upstream open reading frame -2.02061
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -2.01859
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.01798
WDR5B WD repeat domain 5B -2.01713
ADGRF5 adhesion G protein-coupled receptor F5 -2.01587
NOTCH1 notch 1 -2.01524
BZW2 basic leucine zipper and W2 domains 2 -2.0141
TRIM2 tripartite motif containing 2 -2.0122
THSD7A thrombospondin, type I, domain containing 7A -2.00867
CLINT1 clathrin interactor 1 -2.00702
HMGB2 high mobility group box 2 -2.00116