| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 34.95 um perturbation at 48 h in MCF10A (Carcinogenome) |
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76 genes differentially expressed following the CRCGN015_MCF10A_48H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AMDHD2 | amidohydrolase domain containing 2 | 4.04336 |
| APEH | acylaminoacyl-peptide hydrolase | 3.16251 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.93586 |
| HSPB1 | heat shock 27kDa protein 1 | 2.87257 |
| TAC4 | tachykinin 4 (hemokinin) | 2.82744 |
| RPN1 | ribophorin I | 2.68874 |
| GTPBP6 | GTP binding protein 6 (putative) | 2.65338 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.61772 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 2.53196 |
| GMPPA | GDP-mannose pyrophosphorylase A | 2.44629 |
| TBL3 | transducin (beta)-like 3 | 2.43869 |
| FAM50A | family with sequence similarity 50, member A | 2.43266 |
| SH3GLB2 | SH3-domain GRB2-like endophilin B2 | 2.4158 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.39286 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | 2.35824 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 2.32001 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.31239 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 2.27265 |
| MRPS16 | mitochondrial ribosomal protein S16 | 2.25363 |
| CENPB | centromere protein B, 80kDa | 2.23965 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | 2.2145 |
| FLVCR2 | feline leukemia virus subgroup C cellular receptor family, member 2 | 2.20944 |
| THOP1 | thimet oligopeptidase 1 | 2.20274 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 2.2006 |
| H1-10 | H1.10 linker histone | 2.18439 |
| SIL1 | SIL1 nucleotide exchange factor | 2.17139 |
| DCPS | decapping enzyme, scavenger | 2.16021 |
| RAB25 | RAB25, member RAS oncogene family | 2.14896 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.14259 |
| SLC16A6 | solute carrier family 16, member 6 | 2.13337 |
| MAEA | macrophage erythroblast attacher | 2.11792 |
| TMEM147 | transmembrane protein 147 | 2.09369 |
| LAGE3 | L antigen family, member 3 | 2.06789 |
| FASTK | Fas-activated serine/threonine kinase | 2.06233 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 2.05814 |
| CDC25B | cell division cycle 25B | 2.02692 |
| TMEM134 | transmembrane protein 134 | 2.02257 |
| HAS2 | hyaluronan synthase 2 | 2.01893 |
| EMD | emerin | 2.00814 |
| MAGED1 | melanoma antigen family D1 | 2.00521 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DSG2 | desmoglein 2 | -3.45269 |
| CCNB2 | cyclin B2 | -3.38717 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | -3.20504 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | -2.96251 |
| CSRP2 | cysteine and glycine-rich protein 2 | -2.85676 |
| KIF14 | kinesin family member 14 | -2.80636 |
| RNF111 | ring finger protein 111 | -2.66533 |
| ZNF318 | zinc finger protein 318 | -2.61424 |
| VIM | vimentin | -2.54898 |
| RPIA | ribose 5-phosphate isomerase A | -2.53567 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -2.46568 |
| DCP1A | decapping mRNA 1A | -2.43096 |
| ANXA3 | annexin A3 | -2.42967 |
| DPP8 | dipeptidyl-peptidase 8 | -2.40407 |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | -2.39887 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -2.35789 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -2.29087 |
| PHACTR4 | phosphatase and actin regulator 4 | -2.28436 |
| UTF1 | undifferentiated embryonic cell transcription factor 1 | -2.28418 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.28061 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | -2.26441 |
| RND3 | Rho family GTPase 3 | -2.26147 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -2.25285 |
| RGS19 | regulator of G-protein signaling 19 | -2.17454 |
| MECOM | MDS1 and EVI1 complex locus | -2.15306 |
| AQP1 | aquaporin 1 (Colton blood group) | -2.09442 |
| FAM13B | family with sequence similarity 13, member B | -2.08508 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -2.07992 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -2.06887 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -2.06553 |
| BTNL3 | butyrophilin-like 3 | -2.0533 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -2.04718 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | -2.03251 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.01794 |
| NUP153 | nucleoporin 153kDa | -2.0095 |
| WDR47 | WD repeat domain 47 | -2.00123 |
