CRCGN015_MCF10A_48H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 11.65 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN015_MCF10A_48H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 3.46079
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.31611
MCOLN1 mucolipin 1 2.96984
KLHL21 kelch-like family member 21 2.72038
GRWD1 glutamate-rich WD repeat containing 1 2.6312
PNPLA6 patatin-like phospholipase domain containing 6 2.12434

decreased expression

Symbol Name Standardized Value
ANXA3 annexin A3 -4.62525
ISOC1 isochorismatase domain containing 1 -3.91002
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.59257
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.38424
MSMO1 methylsterol monooxygenase 1 -3.36986
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.28141
ENOPH1 enolase-phosphatase 1 -3.01835
DNM1L dynamin 1-like -2.88852
MT2A metallothionein 2A -2.50772
EXOC2 exocyst complex component 2 -2.21678
COPS4 COP9 signalosome subunit 4 -2.21067
MACF1 microtubule-actin crosslinking factor 1 -2.18653
THRAP3 thyroid hormone receptor associated protein 3 -2.15775
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.04495
RNF103-CHMP3 RNF103-CHMP3 readthrough -2.03985
EIPR1 EARP complex and GARP complex interacting protein 1 -2.01349