CRCGN015_MCF10A_48H:C02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptamine 33.33 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN015_MCF10A_48H:C02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.81626
CIAO3 cytosolic iron-sulfur assembly component 3 5.18769
SPAG4 sperm associated antigen 4 4.93265
HBA1 hemoglobin, alpha 1 4.33748
HYOU1 hypoxia up-regulated 1 3.45614
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.02078
HAT1 histone acetyltransferase 1 2.83845
GALNS galactosamine (N-acetyl)-6-sulfatase 2.526
KLHL21 kelch-like family member 21 2.5173
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.29686
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.26955
CTNNBL1 catenin, beta like 1 2.22919
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.21646
SMIM40 small integral membrane protein 40 2.18764
TGIF1 TGFB-induced factor homeobox 1 2.12116
NT5DC2 5'-nucleotidase domain containing 2 2.11191
HBB hemoglobin, beta 2.0647
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.0362
MPHOSPH6 M-phase phosphoprotein 6 2.00277

decreased expression

Symbol Name Standardized Value
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -4.89195
NPDC1 neural proliferation, differentiation and control, 1 -4.85419
FNBP1 formin binding protein 1 -2.69881
STAT1 signal transducer and activator of transcription 1, 91kDa -2.51601
MRPL33 mitochondrial ribosomal protein L33 -2.49665
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.37948
DMAC2L distal membrane arm assembly component 2 like -2.32217
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.29639
ANKRD40 ankyrin repeat domain 40 -2.25813
RET ret proto-oncogene -2.21345
LOC124908558 X antigen family member 1-like -2.20878
EI24 etoposide induced 2.4 -2.18025
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -2.16115
JTB jumping translocation breakpoint -2.15504
TACC1 transforming, acidic coiled-coil containing protein 1 -2.14904
NUP210 nucleoporin 210kDa -2.1347
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -2.12109
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.11976
SFSWAP splicing factor, suppressor of white-apricot family -2.08969
TADA2A transcriptional adaptor 2A -2.07036
TGFBR3 transforming growth factor, beta receptor III -2.06605
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.05603
METTL16 methyltransferase like 16 -2.05008
KMT5A lysine methyltransferase 5A -2.04665
ISCU iron-sulfur cluster assembly enzyme -2.02764
SELL selectin L -2.01376
PLS3 plastin 3 -2.00322