CRCGN015_MCF10A_48H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tranilast 100.0 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

225 genes differentially expressed following the CRCGN015_MCF10A_48H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AXIN1 axin 1 6.1733
H2BC21 H2B clustered histone 21 5.91775
WIF1 WNT inhibitory factor 1 5.10984
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 4.30207
GSTZ1 glutathione S-transferase zeta 1 3.94226
SIRT3 sirtuin 3 3.32206
RGS2 regulator of G-protein signaling 2 2.93475
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.91585
CLTCL1 clathrin, heavy chain-like 1 2.8549
BPTF bromodomain PHD finger transcription factor 2.75427
DGKD diacylglycerol kinase, delta 130kDa 2.75228
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.65792
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.60803
MSRA methionine sulfoxide reductase A 2.57989
LUC7L LUC7-like (S. cerevisiae) 2.53721
MED13 mediator complex subunit 13 2.50801
KLHL2 kelch-like family member 2 2.49508
MAN2A1 mannosidase, alpha, class 2A, member 1 2.48235
RBM6 RNA binding motif protein 6 2.48083
FBXO3 F-box protein 3 2.45
TARDBP TAR DNA binding protein 2.43307
ANKRD11 ankyrin repeat domain 11 2.42516
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.38432
ELL3 elongation factor RNA polymerase II-like 3 2.36751
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.36611
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.36242
SIRT1 sirtuin 1 2.35895
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.3404
CTNNBIP1 catenin, beta interacting protein 1 2.32994
ATP11B ATPase, class VI, type 11B 2.3278
TSPAN4 tetraspanin 4 2.321
ARL17B ADP-ribosylation factor-like 17B 2.28937
F9 coagulation factor IX 2.28864
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.27487
TMEM134 transmembrane protein 134 2.27438
DNMBP dynamin binding protein 2.27085
PGAP6 post-GPI attachment to proteins 6 2.27007
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.2678
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.2378
GSAP gamma-secretase activating protein 2.22039
OSBPL10 oxysterol binding protein-like 10 2.21972
CCNA1 cyclin A1 2.21743
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 2.21672
GPR153 G protein-coupled receptor 153 2.21489
PPOX protoporphyrinogen oxidase 2.21084
EFNA4 ephrin-A4 2.20192
H2AC19 H2A clustered histone 19 2.19585
ARHGAP29 Rho GTPase activating protein 29 2.19418
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.18831
CBR4 carbonyl reductase 4 2.18268
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.15845
PLGLB2 plasminogen-like B2 2.1461
RIGI RNA sensor RIG-I 2.14505
ANO3 anoctamin 3 2.142
CELF1 CUGBP, Elav-like family member 1 2.122
ZBTB44 zinc finger and BTB domain containing 44 2.12063
GRWD1 glutamate-rich WD repeat containing 1 2.11802
KIF13A kinesin family member 13A 2.11656
IFI6 interferon, alpha-inducible protein 6 2.10319
KLF13 Kruppel-like factor 13 2.10202
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.09955
KCTD13 potassium channel tetramerization domain containing 13 2.09339
CALCOCO1 calcium binding and coiled-coil domain 1 2.09205
FHOD1 formin homology 2 domain containing 1 2.09167
STK10 serine/threonine kinase 10 2.08215
KLK5 kallikrein-related peptidase 5 2.08125
TRIM21 tripartite motif containing 21 2.07678
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.06536
TERF2IP telomeric repeat binding factor 2, interacting protein 2.06269
ROGDI rogdi homolog (Drosophila) 2.05835
RPA4 replication protein A4, 30kDa 2.0562
KLHL21 kelch-like family member 21 2.04984
HBA1 hemoglobin, alpha 1 2.04655
TAC1 tachykinin, precursor 1 2.0455
FLG filaggrin 2.04394
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.04063
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 2.02778
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.02119
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 2.01857
OCLN occludin 2.01383
MAPK7 mitogen-activated protein kinase 7 2.01164
BEAN1 brain expressed, associated with NEDD4, 1 2.00298
RIC8A RIC8 guanine nucleotide exchange factor A 2.00212

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.23113
OAT ornithine aminotransferase -4.63458
COG7 component of oligomeric golgi complex 7 -4.63412
CCNB2 cyclin B2 -4.39943
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.38525
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.99128
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.65336
CDC20 cell division cycle 20 -3.62928
PLK1 polo-like kinase 1 -3.51411
CCNA2 cyclin A2 -3.45464
NEK2 NIMA-related kinase 2 -3.30289
KIF20A kinesin family member 20A -3.2716
PCNA proliferating cell nuclear antigen -3.26878
PBK PDZ binding kinase -3.21354
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.14901
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.08395
NFIL3 nuclear factor, interleukin 3 regulated -3.02125
PRMT1 protein arginine methyltransferase 1 -3.00982
KIF14 kinesin family member 14 -2.96799
MELK maternal embryonic leucine zipper kinase -2.93466
TTK TTK protein kinase -2.92906
CDKN3 cyclin-dependent kinase inhibitor 3 -2.9095
CDCA3 cell division cycle associated 3 -2.86308
CDK4 cyclin-dependent kinase 4 -2.82721
CDCA8 cell division cycle associated 8 -2.81895
BIRC5 baculoviral IAP repeat containing 5 -2.80641
ELP5 elongator acetyltransferase complex subunit 5 -2.77133
FXN frataxin -2.76083
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.75876
PRPF19 pre-mRNA processing factor 19 -2.69694
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.69403
CDK1 cyclin-dependent kinase 1 -2.69307
TRIP13 thyroid hormone receptor interactor 13 -2.68668
GTF2A2 general transcription factor IIA, 2, 12kDa -2.66636
LDHB lactate dehydrogenase B -2.64559
LIAS lipoic acid synthetase -2.6449
IPO4 importin 4 -2.63759
MCM6 minichromosome maintenance complex component 6 -2.62479
PRC1 protein regulator of cytokinesis 1 -2.62405
RUVBL2 RuvB-like AAA ATPase 2 -2.61354
TP53RK TP53 regulating kinase -2.56564
CDC25B cell division cycle 25B -2.55181
MCM10 minichromosome maintenance complex component 10 -2.54321
TMEM214 transmembrane protein 214 -2.5327
NMD3 NMD3 ribosome export adaptor -2.51814
TLCD3A TLC domain containing 3A -2.49384
DCK deoxycytidine kinase -2.49041
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.48954
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.48877
PTTG1 pituitary tumor-transforming 1 -2.47025
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.45986
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.43834
TMEM230 transmembrane protein 230 -2.42711
ZNF706 zinc finger protein 706 -2.4254
FASTKD5 FAST kinase domains 5 -2.40259
MRPL46 mitochondrial ribosomal protein L46 -2.40158
PRPF31 pre-mRNA processing factor 31 -2.39347
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.38171
ANAPC1 anaphase promoting complex subunit 1 -2.37798
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.37766
RPL26L1 ribosomal protein L26-like 1 -2.37653
UCK2 uridine-cytidine kinase 2 -2.35292
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.35094
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.35053
EMC8 ER membrane protein complex subunit 8 -2.34818
RUVBL1 RuvB-like AAA ATPase 1 -2.34256
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.34015
RXYLT1 ribitol xylosyltransferase 1 -2.3283
GOLT1B golgi transport 1B -2.31981
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.312
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.3088
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.30864
GEMIN6 gem (nuclear organelle) associated protein 6 -2.30655
KIF11 kinesin family member 11 -2.30575
ERI3 ERI1 exoribonuclease family member 3 -2.28631
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.27594
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.26918
SNRPA small nuclear ribonucleoprotein polypeptide A -2.2647
CENPA centromere protein A -2.26251
PRDX4 peroxiredoxin 4 -2.25924
TIPIN TIMELESS interacting protein -2.25399
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.25156
NCAPG2 non-SMC condensin II complex, subunit G2 -2.24276
EXOSC8 exosome component 8 -2.23674
ASF1B anti-silencing function 1B histone chaperone -2.22524
URM1 ubiquitin related modifier 1 -2.22396
MRPS33 mitochondrial ribosomal protein S33 -2.22337
HIRIP3 HIRA interacting protein 3 -2.21388
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.21147
STMN1 stathmin 1 -2.20283
RFC4 replication factor C (activator 1) 4, 37kDa -2.18858
UBE2C ubiquitin-conjugating enzyme E2C -2.17546
EAPP E2F-associated phosphoprotein -2.16631
RPA3 replication protein A3, 14kDa -2.16553
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.16296
RACGAP1 Rac GTPase activating protein 1 -2.16289
HMGB2 high mobility group box 2 -2.16231
ABHD10 abhydrolase domain containing 10 -2.16193
PITX1 paired-like homeodomain 1 -2.14477
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.14111
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.14046
NOL8 nucleolar protein 8 -2.14007
PCLAF PCNA clamp associated factor -2.1352
NABP2 nucleic acid binding protein 2 -2.13279
H2AZ2 H2A.Z variant histone 2 -2.13207
ZDHHC6 zinc finger, DHHC-type containing 6 -2.1317
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.12739
TPX2 TPX2, microtubule-associated -2.12662
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -2.12251
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.12137
SNRPC small nuclear ribonucleoprotein polypeptide C -2.11901
TSPAN6 tetraspanin 6 -2.11835
TXNL1 thioredoxin-like 1 -2.11727
MSH2 mutS homolog 2 -2.11268
CD58 CD58 molecule -2.11057
NUP37 nucleoporin 37kDa -2.10416
CD164 CD164 molecule, sialomucin -2.10121
CCDC59 coiled-coil domain containing 59 -2.099
PIMREG PICALM interacting mitotic regulator -2.09133
PHB2 prohibitin 2 -2.08837
TMEM267 transmembrane protein 267 -2.08493
ASF1A anti-silencing function 1A histone chaperone -2.08358
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.0805
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.07941
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.07233
KIF23 kinesin family member 23 -2.07229
PNO1 partner of NOB1 homolog (S. cerevisiae) -2.07069
ZWILCH zwilch kinetochore protein -2.06373
SNRPE small nuclear ribonucleoprotein polypeptide E -2.05325
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.05193
FBL fibrillarin -2.05024
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.03385
ODF2 outer dense fiber of sperm tails 2 -2.03263
FAM216A family with sequence similarity 216, member A -2.03065
SRPRB signal recognition particle receptor, B subunit -2.02544
COPZ1 coatomer protein complex, subunit zeta 1 -2.02107
NCAPH non-SMC condensin I complex, subunit H -2.01974
SLC41A3 solute carrier family 41, member 3 -2.01495
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -2.01281
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.00911
GRAP2 GRB2-related adaptor protein 2 -2.0049
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.00297