CRCGN015_MCF10A_48H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tranilast 11.11 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN015_MCF10A_48H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 4.38705
RFX5 regulatory factor X, 5 (influences HLA class II expression) 3.5169
SESN1 sestrin 1 2.85099
PCM1 pericentriolar material 1 2.22364
CHEK2 checkpoint kinase 2 2.03703

decreased expression

Symbol Name Standardized Value
BAG3 BCL2-associated athanogene 3 -5.12136
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.8772
MSMO1 methylsterol monooxygenase 1 -3.66047
PDLIM1 PDZ and LIM domain 1 -3.13617
PRSS23 protease, serine, 23 -2.8544
CTNND1 catenin (cadherin-associated protein), delta 1 -2.71778
CSRP2 cysteine and glycine-rich protein 2 -2.51873
CHAD chondroadherin -2.34079
MAMLD1 mastermind-like domain containing 1 -2.25928
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.25702
DOCK4 dedicator of cytokinesis 4 -2.2399
TCTA T-cell leukemia translocation altered -2.20087
SOAT2 sterol O-acyltransferase 2 -2.17427
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.08985
CA3 carbonic anhydrase III -2.07639
RFTN1 raftlin, lipid raft linker 1 -2.06596
STARD8 StAR-related lipid transfer (START) domain containing 8 -2.06326