CRCGN015_MCF10A_48H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 15-delta-prostaglandin-j2 2.0 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

282 genes differentially expressed following the CRCGN015_MCF10A_48H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 7.81754
NUCB2 nucleobindin 2 5.82537
GLRX glutaredoxin (thioltransferase) 5.77196
TXNRD1 thioredoxin reductase 1 5.2387
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 5.18917
GFPT1 glutamine--fructose-6-phosphate transaminase 1 4.92517
TM9SF2 transmembrane 9 superfamily member 2 4.8728
ARF4 ADP-ribosylation factor 4 4.8697
SQSTM1 sequestosome 1 4.55105
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.20038
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.04769
CLTC clathrin, heavy chain (Hc) 3.942
IFT20 intraflagellar transport 20 3.79749
HDLBP high density lipoprotein binding protein 3.73265
CYB561D2 cytochrome b561 family, member D2 3.44072
NANS N-acetylneuraminic acid synthase 3.37139
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 3.33714
AKTIP AKT interacting protein 3.32433
SEC13 SEC13 homolog (S. cerevisiae) 3.31318
ZNF226 zinc finger protein 226 3.28366
WIPI1 WD repeat domain, phosphoinositide interacting 1 3.23235
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.23168
CDK5RAP2 CDK5 regulatory subunit associated protein 2 3.17608
LOC112694756 uncharaterized LOC112694756 3.17429
GOLGA3 golgin A3 3.15718
GMPPA GDP-mannose pyrophosphorylase A 3.14776
TXNDC15 thioredoxin domain containing 15 3.13197
COPB1 coatomer protein complex, subunit beta 1 3.12383
FKBP14 FK506 binding protein 14, 22 kDa 3.0692
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 3.04719
RABAC1 Rab acceptor 1 (prenylated) 3.04555
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.04175
SKIC2 SKI2 subunit of superkiller complex 3.03611
GORASP2 golgi reassembly stacking protein 2, 55kDa 3.00649
MED8 mediator complex subunit 8 2.97137
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.96649
SEC24A SEC24 family member A 2.91123
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.88055
ACBD3 acyl-CoA binding domain containing 3 2.87199
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.85659
TMEM214 transmembrane protein 214 2.82963
LRP10 low density lipoprotein receptor-related protein 10 2.81318
MAGEH1 melanoma antigen family H1 2.80947
WIF1 WNT inhibitory factor 1 2.78713
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.78406
ISG20 interferon stimulated exonuclease gene 20kDa 2.77898
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.77265
FAM114A1 family with sequence similarity 114, member A1 2.76909
MAGED2 melanoma antigen family D2 2.73535
ARMCX3 armadillo repeat containing, X-linked 3 2.70174
SEC24C SEC24 family member C 2.69994
GOLT1B golgi transport 1B 2.69445
COPZ2 coatomer protein complex, subunit zeta 2 2.68062
UFM1 ubiquitin-fold modifier 1 2.67362
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.66424
GMPPB GDP-mannose pyrophosphorylase B 2.66007
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.59091
PRRC1 proline-rich coiled-coil 1 2.58747
NDEL1 nudE neurodevelopment protein 1-like 1 2.58479
AKR1C1 aldo-keto reductase family 1, member C1 2.58438
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.56337
YIPF2 Yip1 domain family, member 2 2.56032
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.55785
MINDY1 MINDY lysine 48 deubiquitinase 1 2.55649
GCLM glutamate-cysteine ligase, modifier subunit 2.5558
SIL1 SIL1 nucleotide exchange factor 2.55426
PRAF2 PRA1 domain family, member 2 2.54097
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.5236
MAGED1 melanoma antigen family D1 2.52257
TMCO1 transmembrane and coiled-coil domains 1 2.51779
EMC7 ER membrane protein complex subunit 7 2.49983
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.49193
TFG TRK-fused gene 2.4795
GPX2 glutathione peroxidase 2 2.47613
CBR1 carbonyl reductase 1 2.45008
UFL1 UFM1-specific ligase 1 2.44386
YIPF3 Yip1 domain family, member 3 2.42065
CHMP2A charged multivesicular body protein 2A 2.42023
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.41205
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.40222
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.3994
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.39688
BCAS1 breast carcinoma amplified sequence 1 2.39518
ULBP2 UL16 binding protein 2 2.39027
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.38812
ATG7 autophagy related 7 2.38801
ALAS1 5'-aminolevulinate synthase 1 2.38346
SECISBP2L SECIS binding protein 2-like 2.38165
AKR1C3 aldo-keto reductase family 1, member C3 2.3633
TMEM208 transmembrane protein 208 2.3621
GOLGB1 golgin B1 2.34869
COPG1 coatomer protein complex, subunit gamma 1 2.34591
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.32989
FICD FIC domain containing 2.32565
FAM8A1 family with sequence similarity 8, member A1 2.32199
CES1 carboxylesterase 1 2.31382
YME1L1 YME1-like 1 ATPase 2.31094
LGSN lengsin, lens protein with glutamine synthetase domain 2.30748
ELOVL1 ELOVL fatty acid elongase 1 2.30375
SERP1 stress-associated endoplasmic reticulum protein 1 2.30327
CREB3L4 cAMP responsive element binding protein 3-like 4 2.29866
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.29585
KLHDC2 kelch domain containing 2 2.28366
GOLGA1 golgin A1 2.27811
DAD1 defender against cell death 1 2.26881
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.26741
GK glycerol kinase 2.26167
SEC61B Sec61 beta subunit 2.25875
TALDO1 transaldolase 1 2.25868
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.25828
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.25573
NECAP1 NECAP endocytosis associated 1 2.25566
GABARAPL1 GABA(A) receptor-associated protein like 1 2.25468
ITFG1 integrin alpha FG-GAP repeat containing 1 2.24118
ACOT13 acyl-CoA thioesterase 13 2.24092
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.23065
GCLC glutamate-cysteine ligase, catalytic subunit 2.22433
ITPRID2 ITPR interacting domain containing 2 2.22101
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 2.21901
SCFD1 sec1 family domain containing 1 2.2161
SEC31A SEC31 homolog A (S. cerevisiae) 2.20193
TSG101 tumor susceptibility 101 2.20072
CALCOCO1 calcium binding and coiled-coil domain 1 2.19435
RER1 retention in endoplasmic reticulum sorting receptor 1 2.19422
MANF mesencephalic astrocyte-derived neurotrophic factor 2.19287
TRIM16 tripartite motif containing 16 2.19053
WBP1L WW domain binding protein 1-like 2.18575
ZNHIT1 zinc finger, HIT-type containing 1 2.18015
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 2.17714
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.17495
BLVRB biliverdin reductase B 2.16982
MYDGF myeloid-derived growth factor 2.16923
LGALS8 lectin, galactoside-binding, soluble, 8 2.16264
SRPRB signal recognition particle receptor, B subunit 2.1581
TEX2 testis expressed 2 2.15614
SAR1B secretion associated, Ras related GTPase 1B 2.15197
SDF2 stromal cell-derived factor 2 2.14704
TMBIM4 transmembrane BAX inhibitor motif containing 4 2.14173
DYNLT3 dynein, light chain, Tctex-type 3 2.13145
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.12684
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.12296
GOLGA2 golgin A2 2.11942
RND1 Rho family GTPase 1 2.11887
TSLIG3A tRNA splicing ligase complex subunit 3A 2.11103
EMC3 ER membrane protein complex subunit 3 2.09235
DNASE2 deoxyribonuclease II, lysosomal 2.08914
OSTF1 osteoclast stimulating factor 1 2.08639
SAP30BP SAP30 binding protein 2.086
STX5 syntaxin 5 2.07345
TRIM52 tripartite motif containing 52 2.06732
ZNF536 zinc finger protein 536 2.06508
ZNF222 zinc finger protein 222 2.06497
TREM1 triggering receptor expressed on myeloid cells 1 2.05907
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.04983
OSGIN1 oxidative stress induced growth inhibitor 1 2.04866
SLC35E1 solute carrier family 35, member E1 2.04784
AMZ2 archaelysin family metallopeptidase 2 2.03785
FKBP11 FK506 binding protein 11, 19 kDa 2.03196
TRIM13 tripartite motif containing 13 2.02984
HEMK1 HemK methyltransferase family member 1 2.02437
TFF1 trefoil factor 1 2.02184
LHB luteinizing hormone beta polypeptide 2.01912
SEC16A SEC16 homolog A (S. cerevisiae) 2.01746
SRP54 signal recognition particle 54kDa 2.01352
ARCN1 archain 1 2.00637
TMEM255A transmembrane protein 255A 2.00376

decreased expression

Symbol Name Standardized Value
ANXA3 annexin A3 -5.72947
MSMO1 methylsterol monooxygenase 1 -5.27779
CDC25B cell division cycle 25B -4.10043
SLC35F2 solute carrier family 35, member F2 -4.04747
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.8
HADH hydroxyacyl-CoA dehydrogenase -3.79108
HEBP1 heme binding protein 1 -3.61243
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.58599
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.47512
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -3.29151
RUVBL1 RuvB-like AAA ATPase 1 -3.19429
STMN1 stathmin 1 -3.11442
DCK deoxycytidine kinase -3.09319
KIF20A kinesin family member 20A -3.0691
MELK maternal embryonic leucine zipper kinase -3.04567
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.02942
TTK TTK protein kinase -2.98838
KIF11 kinesin family member 11 -2.92314
SNRPA small nuclear ribonucleoprotein polypeptide A -2.92195
CASP8AP2 caspase 8 associated protein 2 -2.85585
KIF18B kinesin family member 18B -2.80507
MCUR1 mitochondrial calcium uniporter regulator 1 -2.73499
TOP2A topoisomerase (DNA) II alpha 170kDa -2.70208
NDC1 NDC1 transmembrane nucleoporin -2.67701
FOXM1 forkhead box M1 -2.66155
LAP3 leucine aminopeptidase 3 -2.63604
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.62599
HMG20B high mobility group 20B -2.61986
NCAPD3 non-SMC condensin II complex, subunit D3 -2.56992
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.49543
COG7 component of oligomeric golgi complex 7 -2.49217
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.48921
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.46621
LY6E lymphocyte antigen 6 complex, locus E -2.45679
SPDL1 spindle apparatus coiled-coil protein 1 -2.43154
BTBD2 BTB (POZ) domain containing 2 -2.42184
CAPN15 calpain 15 -2.41609
CDC20 cell division cycle 20 -2.40546
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.40236
HMGB2 high mobility group box 2 -2.39938
CDK2 cyclin-dependent kinase 2 -2.39754
CCNA2 cyclin A2 -2.38203
PALB2 partner and localizer of BRCA2 -2.37404
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.35891
KIF15 kinesin family member 15 -2.35889
TCEAL4 transcription elongation factor A (SII)-like 4 -2.35005
HDAC2 histone deacetylase 2 -2.3459
CRYBG1 crystallin beta-gamma domain containing 1 -2.34575
USP39 ubiquitin specific peptidase 39 -2.34334
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.33782
NCAPG2 non-SMC condensin II complex, subunit G2 -2.32786
PUS7 pseudouridylate synthase 7 (putative) -2.32771
NUP205 nucleoporin 205kDa -2.31254
ENOPH1 enolase-phosphatase 1 -2.31213
PUS1 pseudouridylate synthase 1 -2.30197
LMNB1 lamin B1 -2.29461
CCNB2 cyclin B2 -2.29372
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.29267
NOP14 NOP14 nucleolar protein -2.28807
FLNA filamin A, alpha -2.27923
CDK1 cyclin-dependent kinase 1 -2.26872
TROAP trophinin associated protein -2.26554
MCMBP minichromosome maintenance complex binding protein -2.26206
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.26175
UBE2C ubiquitin-conjugating enzyme E2C -2.25974
KIF14 kinesin family member 14 -2.25225
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.24476
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.24449
RNPS1 RNA binding protein S1, serine-rich domain -2.22585
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.22396
ISOC1 isochorismatase domain containing 1 -2.22164
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.22142
ASF1B anti-silencing function 1B histone chaperone -2.22132
SPC25 SPC25, NDC80 kinetochore complex component -2.21209
KIF4A kinesin family member 4A -2.20756
TTC27 tetratricopeptide repeat domain 27 -2.20485
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.18429
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.18297
CARM1 coactivator-associated arginine methyltransferase 1 -2.18255
HOXA10-HOXA9 HOXA10-HOXA9 readthrough -2.16914
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.15744
TWNK twinkle mtDNA helicase -2.15508
H1-10 H1.10 linker histone -2.1519
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.14205
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.12518
PHACTR4 phosphatase and actin regulator 4 -2.12222
ADGRE5 adhesion G protein-coupled receptor E5 -2.11103
PFAS phosphoribosylformylglycinamidine synthase -2.10266
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.10205
PRC1 protein regulator of cytokinesis 1 -2.09974
NEK2 NIMA-related kinase 2 -2.09357
WDR18 WD repeat domain 18 -2.09194
RIOX1 ribosomal oxygenase 1 -2.08279
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.08111
SUMF2 sulfatase modifying factor 2 -2.07667
RMI1 RecQ mediated genome instability 1 -2.07616
MRPS27 mitochondrial ribosomal protein S27 -2.07393
CHEK1 checkpoint kinase 1 -2.07198
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.06597
CDC7 cell division cycle 7 -2.06412
PDLIM1 PDZ and LIM domain 1 -2.06341
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.06278
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.06203
ZWINT ZW10 interacting kinetochore protein -2.04932
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.03943
CKAP2 cytoskeleton associated protein 2 -2.03638
CENPU centromere protein U -2.03237
MDN1 MDN1, midasin homolog (yeast) -2.03031
RFC3 replication factor C (activator 1) 3, 38kDa -2.02949
MTA2 metastasis associated 1 family, member 2 -2.02807
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02551
CEP55 centrosomal protein 55kDa -2.01641
SLC43A3 solute carrier family 43, member 3 -2.01484
GALP galanin-like peptide -2.01414
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.00751
TPX2 TPX2, microtubule-associated -2.00378