CRCGN015_MCF10A_48H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 99.96 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN015_MCF10A_48H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.76695
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.65635
ZNF589 zinc finger protein 589 4.23812
SLC75A1 solute carrier family 75 member 1 2.668
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.51235
KYAT1 kynurenine aminotransferase 1 2.3919
TMEM38B transmembrane protein 38B 2.28315
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.204
HSPA4L heat shock 70kDa protein 4-like 2.0799
S100A3 S100 calcium binding protein A3 2.074

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -5.4129
COG7 component of oligomeric golgi complex 7 -4.89425
GNAS GNAS complex locus -4.73786
VIM vimentin -4.55825
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.14748
TUBA1C tubulin, alpha 1c -2.98822
TUBA1B tubulin, alpha 1b -2.7181
MAB21L4 mab-21 like 4 -2.6362
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.63525
RPN2 ribophorin II -2.62502
TUBA1A tubulin, alpha 1a -2.53129
LOC122539214 Zinc finger protein LOC122539214 -2.5217
RPL38 ribosomal protein L38 -2.51855
CHAD chondroadherin -2.5064
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -2.48155
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.4631
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.407
ATP5F1E ATP synthase F1 subunit epsilon -2.2858
MSLN mesothelin -2.28355
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.232
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.23185
ARHGAP44 Rho GTPase activating protein 44 -2.21898
ZNF354A zinc finger protein 354A -2.1764
ZIM3 zinc finger, imprinted 3 -2.1435
ZNF205 zinc finger protein 205 -2.14205
MATN3 matrilin 3 -2.12455
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.12345
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.11905
RASAL2 RAS protein activator like 2 -2.1178
CHGB chromogranin B -2.11375
ASS1 argininosuccinate synthase 1 -2.11265
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 -2.10775
NELFCD negative elongation factor complex member C/D -2.07125
ZNF223 zinc finger protein 223 -2.07025
SIX6 SIX homeobox 6 -2.06715
KIF3B kinesin family member 3B -2.06185
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.04725
RNF130 ring finger protein 130 -2.0326
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.02202
LOC128966570 alpha-amylase 1B -2.0197
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.00955
MEOX2 mesenchyme homeobox 2 -2.00585
SIM1 single-minded family bHLH transcription factor 1 -2.00495