CRCGN015_MCF10A_48H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 33.32 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN015_MCF10A_48H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.79907
AXIN1 axin 1 3.34877
CIAO3 cytosolic iron-sulfur assembly component 3 3.07065
MAP7 microtubule-associated protein 7 2.89935
ANO10 anoctamin 10 2.73561
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.70864
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.51776
SPAG4 sperm associated antigen 4 2.1705
ADAM10 ADAM metallopeptidase domain 10 2.15988
BOLA1 bolA family member 1 2.09904
TMEM50B transmembrane protein 50B 2.0905

decreased expression

Symbol Name Standardized Value
VIM vimentin -3.39155
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.25352
OXA1L oxidase (cytochrome c) assembly 1-like -3.02442
PUF60 poly-U binding splicing factor 60KDa -2.81472
PLK2 polo-like kinase 2 -2.78361
MAPK13 mitogen-activated protein kinase 13 -2.48538
METTL17 methyltransferase like 17 -2.46147
SCRIB scribbled planar cell polarity protein -2.40712
MCUR1 mitochondrial calcium uniporter regulator 1 -2.38806
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.29593
ARMH3 armadillo like helical domain containing 3 -2.12811
MSMO1 methylsterol monooxygenase 1 -2.05707
KIF5C kinesin family member 5C -2.05452
CHD8 chromodomain helicase DNA binding protein 8 -2.05006
CCDC86 coiled-coil domain containing 86 -2.01961
KIF13A kinesin family member 13A -2.01432