CRCGN015_MCF10A_48H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description serotonin 100.0 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN015_MCF10A_48H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.70491
WIF1 WNT inhibitory factor 1 3.67569
MAMLD1 mastermind-like domain containing 1 3.64286
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.5581
STAP2 signal transducing adaptor family member 2 3.5571
LAGE3 L antigen family, member 3 3.25816
SMIM40 small integral membrane protein 40 3.1912
CXCR4 chemokine (C-X-C motif) receptor 4 3.06783
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.95054
PDLIM1 PDZ and LIM domain 1 2.80816
PECR peroxisomal trans-2-enoyl-CoA reductase 2.67443
TIAM1 T-cell lymphoma invasion and metastasis 1 2.60985
HBA1 hemoglobin, alpha 1 2.54766
BFAR bifunctional apoptosis regulator 2.49433
IPO13 importin 13 2.37566
CHN1 chimerin 1 2.34244
PPOX protoporphyrinogen oxidase 2.30959
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.27455
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.24523
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.22466
RAB13 RAB13, member RAS oncogene family 2.19397
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.07647
ADAT1 adenosine deaminase, tRNA-specific 1 2.07314
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.05356
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 2.03799
TMEM101 transmembrane protein 101 2.02698
CHIT1 chitinase 1 (chitotriosidase) 2.00308

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.90237
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.73697
ANXA3 annexin A3 -3.67569
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.52105
MSMO1 methylsterol monooxygenase 1 -3.47871
SCYL3 SCY1-like 3 (S. cerevisiae) -2.75298
GSTA4 glutathione S-transferase alpha 4 -2.43814
DCK deoxycytidine kinase -2.38194
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.20691
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.17846
PLK2 polo-like kinase 2 -2.10934
RHOB ras homolog family member B -2.09051
SECISBP2 SECIS binding protein 2 -2.07979
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -2.06527
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -2.05909
PAIP1 poly(A) binding protein interacting protein 1 -2.03424
S100A11 S100 calcium binding protein A11 -2.01126