CRCGN015_MCF10A_48H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description serotonin 33.33 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN015_MCF10A_48H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MINDY1 MINDY lysine 48 deubiquitinase 1 4.18966
SSBP2 single-stranded DNA binding protein 2 3.56515
CNPY3 canopy FGF signaling regulator 3 3.24248
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.20678
STAP2 signal transducing adaptor family member 2 3.20469
ILK integrin-linked kinase 2.96114
CCDC92 coiled-coil domain containing 92 2.88757
SNAP25 synaptosomal-associated protein, 25kDa 2.84854
MYLK myosin light chain kinase 2.74306
SV2B synaptic vesicle glycoprotein 2B 2.73875
PANK2 pantothenate kinase 2 2.63529
MAP2K5 mitogen-activated protein kinase kinase 5 2.61863
E2F2 E2F transcription factor 2 2.58408
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.5786
DEFB126 defensin, beta 126 2.48153
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.38416
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.30407
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.28899
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.26802
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.26014
EPHB6 EPH receptor B6 2.25568
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.22418
GFRA3 GDNF family receptor alpha 3 2.21094
NUP42 nucleoporin 42 2.18686
TPSD1 tryptase delta 1 2.18678
TSGA10 testis specific, 10 2.1787
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.16763
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.1476
ATL2 atlastin GTPase 2 2.14625
LIMD2 LIM domain containing 2 2.14302
KLK5 kallikrein-related peptidase 5 2.12825
ZNF835 zinc finger protein 835 2.12517
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.10363
GRHL2 grainyhead-like 2 (Drosophila) 2.09867
TXNIP thioredoxin interacting protein 2.09846
ZNF528 zinc finger protein 528 2.09501
PCSK2 proprotein convertase subtilisin/kexin type 2 2.08795
TMOD1 tropomodulin 1 2.07817
TMEM143 transmembrane protein 143 2.07708
ZNF253 zinc finger protein 253 2.07524
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.05165
MCHR1 melanin-concentrating hormone receptor 1 2.04973
IGHMBP2 immunoglobulin mu binding protein 2 2.0492
RPL10L ribosomal protein L10-like 2.02734
NRGN neurogranin (protein kinase C substrate, RC3) 2.02644
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.02454
SRBD1 S1 RNA binding domain 1 2.02411
PPCDC phosphopantothenoylcysteine decarboxylase 2.01164

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -4.95535
MSMO1 methylsterol monooxygenase 1 -3.99342
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.85348
COG7 component of oligomeric golgi complex 7 -3.71795
PLS1 plastin 1 -3.49195
VDAC1 voltage-dependent anion channel 1 -3.18419
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.9967
PLK2 polo-like kinase 2 -2.80408
TM9SF3 transmembrane 9 superfamily member 3 -2.71754
CSRP2 cysteine and glycine-rich protein 2 -2.57142
NFIL3 nuclear factor, interleukin 3 regulated -2.42903
RNF130 ring finger protein 130 -2.36865
PCCB propionyl CoA carboxylase, beta polypeptide -2.34169
CARM1 coactivator-associated arginine methyltransferase 1 -2.22362
CCDC86 coiled-coil domain containing 86 -2.21696
COG2 component of oligomeric golgi complex 2 -2.2007
SOAT2 sterol O-acyltransferase 2 -2.17265
ANXA3 annexin A3 -2.15268
ATP5F1B ATP synthase F1 subunit beta -2.07743
CDK4 cyclin-dependent kinase 4 -2.07458
TMEM109 transmembrane protein 109 -2.07117
CST7 cystatin F (leukocystatin) -2.06353
CTSC cathepsin C -2.04431
DOLPP1 dolichyldiphosphatase 1 -2.00828