CRCGN015_MCF10A_48H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN015_MCF10A_48H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 3.25102
MCOLN1 mucolipin 1 3.21813
HBA1 hemoglobin, alpha 1 2.95767
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.60415
S100A4 S100 calcium binding protein A4 2.59024
TREM1 triggering receptor expressed on myeloid cells 1 2.5442
PRKCH protein kinase C, eta 2.45612
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.42075
HAT1 histone acetyltransferase 1 2.35243
DNASE1L3 deoxyribonuclease I-like 3 2.21772
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.18899
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A 2.18647
BZW2 basic leucine zipper and W2 domains 2 2.13991
ELAC2 elaC ribonuclease Z 2 2.12764
GPR52 G protein-coupled receptor 52 2.06017
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.04294

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -7.60596
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.41712
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.11287
SQLE squalene epoxidase -2.89991
IGFBP7 insulin-like growth factor binding protein 7 -2.76091
MVD mevalonate (diphospho) decarboxylase -2.61445
ANXA3 annexin A3 -2.46983
NBEAL2 neurobeachin-like 2 -2.39756
MVP major vault protein -2.38352
STK25 serine/threonine kinase 25 -2.347
DHCR24 24-dehydrocholesterol reductase -2.32471
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.2889
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.17465
MYL9 myosin, light chain 9, regulatory -2.155
TNIP1 TNFAIP3 interacting protein 1 -2.11224
GASK1B golgi associated kinase 1B -2.04731
PGC progastricsin (pepsinogen C) -2.04692
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.02946
KLC3 kinesin light chain 3 -2.01697
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.01656