CRCGN015_MCF10A_48H:D07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 99.96 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A_48H:D07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 3.8628
SMIM40 small integral membrane protein 40 3.63573
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 3.22879
DDR1 discoidin domain receptor tyrosine kinase 1 3.1829
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.85748
UBL5 ubiquitin-like 5 2.65351
NT5DC2 5'-nucleotidase domain containing 2 2.6519
NELFCD negative elongation factor complex member C/D 2.61536
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.43918
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.43388
WDR83OS WD repeat domain 83 opposite strand 2.4324
MOCS2 molybdenum cofactor synthesis 2 2.36092
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.26753
LCMT1 leucine carboxyl methyltransferase 1 2.21666
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.15147
CCNH cyclin H 2.14302
RNF170 ring finger protein 170 2.11298
SNRPF small nuclear ribonucleoprotein polypeptide F 2.08542
BFAR bifunctional apoptosis regulator 2.08087
PLA2G12A phospholipase A2, group XIIA 2.04574
WIF1 WNT inhibitory factor 1 2.0218
NDN necdin, melanoma antigen (MAGE) family member 2.0133
CHMP2B charged multivesicular body protein 2B 2.01328

decreased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic -4.82623
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.47461
LAP3 leucine aminopeptidase 3 -4.46105
CHIC2 cysteine-rich hydrophobic domain 2 -3.89987
MT2A metallothionein 2A -3.0833
KRT14 keratin 14, type I -3.06417
MORF4L2 mortality factor 4 like 2 -2.58522
TGM2 transglutaminase 2 -2.47951
DUSP2 dual specificity phosphatase 2 -2.3826
CSF1R colony stimulating factor 1 receptor -2.30982
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -2.2907
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.24603
LOC124907782 dual specificity protein phosphatase 22 -2.22384
SRGN serglycin -2.21415
GLOD4 glyoxalase domain containing 4 -2.12593
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.09572
TH tyrosine hydroxylase -2.09025
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -2.06488
ADGRG1 adhesion G protein-coupled receptor G1 -2.04815
FCHSD2 FCH and double SH3 domains 2 -2.01359