CRCGN015_MCF10A_48H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 33.32 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN015_MCF10A_48H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.63473
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.98258
GRB10 growth factor receptor-bound protein 10 4.07203
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.81099
OR7A5 olfactory receptor, family 7, subfamily A, member 5 3.02556
PRKG2 protein kinase, cGMP-dependent, type II 2.70456
ACTL6A actin-like 6A 2.64889
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.59091
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.58749
PRELID3A PRELI domain containing 3A 2.55187
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.4397
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.42352
IHH indian hedgehog 2.42039
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.39861
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.37074
PRMT3 protein arginine methyltransferase 3 2.34115
IL21 interleukin 21 2.32757
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.31457
TENM1 teneurin transmembrane protein 1 2.30931
GAR1 GAR1 ribonucleoprotein 2.30082
STEEP1 STING1 ER exit protein 1 2.28439
APLNR apelin receptor 2.27403
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.27396
ZNF282 zinc finger protein 282 2.26118
CIDEB cell death-inducing DFFA-like effector b 2.26023
OR51E2 olfactory receptor, family 51, subfamily E, member 2 2.25777
SLC17A4 solute carrier family 17, member 4 2.25381
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.24258
ONECUT2 one cut homeobox 2 2.23812
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.23738
EPB42 erythrocyte membrane protein band 4.2 2.22798
TRIM49D2 tripartite motif containing 49D2 2.22689
CLASRP CLK4-associating serine/arginine rich protein 2.22126
BCL3 B-cell CLL/lymphoma 3 2.20603
MYBPC1 myosin binding protein C, slow type 2.18837
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.17954
CHN1 chimerin 1 2.17719
CRYGB crystallin, gamma B 2.17504
ERBIN erbb2 interacting protein 2.15527
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.14257
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.13724
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 2.13486
WIF1 WNT inhibitory factor 1 2.13467
CXCL13 chemokine (C-X-C motif) ligand 13 2.12972
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.1294
TESPA1 thymocyte expressed, positive selection associated 1 2.12333
MARK3 MAP/microtubule affinity-regulating kinase 3 2.1152
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.11064
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.10239
MEPE matrix extracellular phosphoglycoprotein 2.09128
TRAPPC4 trafficking protein particle complex 4 2.08786
FBXO46 F-box protein 46 2.08714
MEP1B meprin A, beta 2.08699
PTPRJ protein tyrosine phosphatase, receptor type, J 2.08058
EMID1 EMI domain containing 1 2.0796
CLUL1 clusterin-like 1 (retinal) 2.07932
SSX4B synovial sarcoma, X breakpoint 4B 2.073
LRRC40 leucine rich repeat containing 40 2.07075
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.06372
CD5L CD5 molecule-like 2.05981
KRT16 keratin 16, type I 2.05774
TMCC2 transmembrane and coiled-coil domain family 2 2.04326
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.03811
AUH AU RNA binding protein/enoyl-CoA hydratase 2.0362
CNTNAP2 contactin associated protein-like 2 2.03545
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.02895
DNM2 dynamin 2 2.02595
KRT1 keratin 1, type II 2.02039
ZNF280A zinc finger protein 280A 2.00783
ADAMDEC1 ADAM-like, decysin 1 2.00712
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.00601

decreased expression

Symbol Name Standardized Value
PLK2 polo-like kinase 2 -5.0
RGS2 regulator of G-protein signaling 2 -4.94662
NCK1 NCK adaptor protein 1 -4.28514
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.2423
ANXA3 annexin A3 -3.98315
SCYL3 SCY1-like 3 (S. cerevisiae) -3.84428
MFAP4 microfibrillar-associated protein 4 -2.81563
TENT5A terminal nucleotidyltransferase 5A -2.497
FLNA filamin A, alpha -2.49685
CHRDL1 chordin-like 1 -2.27775
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.27641
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.27091
CTNNBL1 catenin, beta like 1 -2.22196
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.22144
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.2079
LAMA2 laminin, alpha 2 -2.20702
ASRGL1 asparaginase like 1 -2.19564
JAK1 Janus kinase 1 -2.18818
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.15287
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.14945
GAB2 GRB2-associated binding protein 2 -2.14654
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.12562
CRYBG3 beta-gamma crystallin domain containing 3 -2.11997
SETBP1 SET binding protein 1 -2.09878
SMAGP small cell adhesion glycoprotein -2.09431
THBS4 thrombospondin 4 -2.0934
ING1 inhibitor of growth family, member 1 -2.0924
MGMT O-6-methylguanine-DNA methyltransferase -2.08037
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.06275
PLSCR4 phospholipid scramblase 4 -2.06166
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.04485
L1TD1 LINE-1 type transposase domain containing 1 -2.03606
OLFML3 olfactomedin-like 3 -2.02988
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.00843
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.00019