CRCGN015_MCF10A_48H:D11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 34.5 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN015_MCF10A_48H:D11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BZW2 basic leucine zipper and W2 domains 2 3.77727
CHMP6 charged multivesicular body protein 6 3.33868
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.14632
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.48924
HSPB1 heat shock 27kDa protein 1 2.46433
PECR peroxisomal trans-2-enoyl-CoA reductase 2.42812
CXCL2 chemokine (C-X-C motif) ligand 2 2.25121
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.24339
TSKU tsukushi, small leucine rich proteoglycan 2.23818
AOPEP aminopeptidase O (putative) 2.20673
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.06925
BBC3 BCL2 binding component 3 2.01538
TSPAN6 tetraspanin 6 2.00509

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -3.83465
CCDC86 coiled-coil domain containing 86 -3.37528
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.32106
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.09116
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.97967
UBE2A ubiquitin-conjugating enzyme E2A -2.86145
MT2A metallothionein 2A -2.31181
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.28543
HSPA1A heat shock 70kDa protein 1A -2.22212
RPN1 ribophorin I -2.21976
CTPS2 CTP synthase 2 -2.15452
KIF16B kinesin family member 16B -2.05543
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.0233