CRCGN015_MCF10A_48H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 98.44 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_MCF10A_48H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.34552
AXIN1 axin 1 3.14237
ELAC2 elaC ribonuclease Z 2 2.68333
MYLK myosin light chain kinase 2.67882
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 2.39698
KCTD5 potassium channel tetramerization domain containing 5 2.38594
TACC1 transforming, acidic coiled-coil containing protein 1 2.28904
PDIA5 protein disulfide isomerase family A, member 5 2.25342
ACTA2 actin, alpha 2, smooth muscle, aorta 2.24502
IGHMBP2 immunoglobulin mu binding protein 2 2.24088
FPGS folylpolyglutamate synthase 2.18097
FIP1L1 factor interacting with PAPOLA and CPSF1 2.12733
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.12576
IQGAP2 IQ motif containing GTPase activating protein 2 2.12435
ERP29 endoplasmic reticulum protein 29 2.0433

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.83805
TXNDC9 thioredoxin domain containing 9 -3.31313
VDAC1 voltage-dependent anion channel 1 -3.14248
NPDC1 neural proliferation, differentiation and control, 1 -2.97487
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.90726
KCTD2 potassium channel tetramerization domain containing 2 -2.71926
NUP85 nucleoporin 85kDa -2.56798
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.41697
SLC25A46 solute carrier family 25, member 46 -2.24106
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.18699
HEATR1 HEAT repeat containing 1 -2.1611
SUMO4 small ubiquitin-like modifier 4 -2.14629
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.08292
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.05013
ZCCHC10 zinc finger, CCHC domain containing 10 -2.04511
FANCF Fanconi anemia, complementation group F -2.02281