| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 10.73 um perturbation at 48 h in MCF10A (Carcinogenome) |
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135 genes differentially expressed following the CRCGN015_MCF10A_48H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 4.92527 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.05421 |
| SMIM40 | small integral membrane protein 40 | 4.04794 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.02078 |
| STK10 | serine/threonine kinase 10 | 3.99201 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.72659 |
| ZNF589 | zinc finger protein 589 | 3.61324 |
| DLK1 | delta-like 1 homolog (Drosophila) | 3.31685 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | 3.17984 |
| EPN2 | epsin 2 | 3.0409 |
| DPM2 | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit | 2.84594 |
| CCNA1 | cyclin A1 | 2.75496 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.71514 |
| BCL3 | B-cell CLL/lymphoma 3 | 2.70807 |
| CDK19 | cyclin-dependent kinase 19 | 2.68771 |
| GTF3C5 | general transcription factor IIIC, polypeptide 5, 63kDa | 2.67283 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 2.65799 |
| FPGS | folylpolyglutamate synthase | 2.63884 |
| SMPD2 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 2.58889 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.58794 |
| FXN | frataxin | 2.54652 |
| UBE2M | ubiquitin-conjugating enzyme E2M | 2.54646 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 2.54645 |
| TMX2 | thioredoxin-related transmembrane protein 2 | 2.51831 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 2.50581 |
| MYLK3 | myosin light chain kinase 3 | 2.46797 |
| COL6A1 | collagen, type VI, alpha 1 | 2.46265 |
| TPRA1 | transmembrane protein, adipocyte asscociated 1 | 2.42508 |
| NEFH | neurofilament, heavy polypeptide | 2.39667 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 2.3966 |
| PCM1 | pericentriolar material 1 | 2.36708 |
| FOXA2 | forkhead box A2 | 2.34261 |
| POPDC2 | popeye domain containing 2 | 2.33227 |
| CDK9 | cyclin-dependent kinase 9 | 2.3284 |
| COL6A2 | collagen, type VI, alpha 2 | 2.32481 |
| CEP57 | centrosomal protein 57kDa | 2.31496 |
| MYO19 | myosin XIX | 2.30979 |
| RALGPS1 | Ral GEF with PH domain and SH3 binding motif 1 | 2.30482 |
| POGLUT2 | protein O-glucosyltransferase 2 | 2.29592 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 2.28164 |
| MVB12B | multivesicular body subunit 12B | 2.2327 |
| UXS1 | UDP-glucuronate decarboxylase 1 | 2.22942 |
| PRKCE | protein kinase C, epsilon | 2.22609 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 2.21882 |
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | 2.21628 |
| ISOC2 | isochorismatase domain containing 2 | 2.20804 |
| PRRC2B | proline-rich coiled-coil 2B | 2.17775 |
| UBASH3A | ubiquitin associated and SH3 domain containing A | 2.16932 |
| F2RL2 | coagulation factor II (thrombin) receptor-like 2 | 2.14201 |
| RBM38 | RNA binding motif protein 38 | 2.12086 |
| ODF2 | outer dense fiber of sperm tails 2 | 2.11673 |
| HOXD11 | homeobox D11 | 2.11502 |
| MAPK9 | mitogen-activated protein kinase 9 | 2.10895 |
| COL9A3 | collagen, type IX, alpha 3 | 2.10207 |
| PSME3IP1 | proteasome activator subunit 3 interacting protein 1 | 2.09907 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 2.0973 |
| GALT | galactose-1-phosphate uridylyltransferase | 2.08039 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | 2.06677 |
| PIGN | phosphatidylinositol glycan anchor biosynthesis, class N | 2.06031 |
| CCDC88A | coiled-coil domain containing 88A | 2.03693 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | 2.03163 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 2.02336 |
| RIPOR1 | RHO family interacting cell polarization regulator 1 | 2.01627 |
| ITPA | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 2.01093 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MSMO1 | methylsterol monooxygenase 1 | -6.44797 |
| PLK2 | polo-like kinase 2 | -4.7263 |
| KRT7 | keratin 7, type II | -4.47703 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -4.47453 |
| PLS1 | plastin 1 | -4.11392 |
| LAP3 | leucine aminopeptidase 3 | -4.03561 |
| S100A8 | S100 calcium binding protein A8 | -4.02321 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.90975 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -3.85478 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -3.74513 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.6946 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -3.66269 |
| DUSP6 | dual specificity phosphatase 6 | -3.56366 |
| DUSP4 | dual specificity phosphatase 4 | -3.38366 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -3.21131 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | -3.16615 |
| MYT1 | myelin transcription factor 1 | -2.98935 |
| COA7 | cytochrome c oxidase assembly factor 7 (putative) | -2.87484 |
| OAT | ornithine aminotransferase | -2.83463 |
| XAF1 | XIAP associated factor 1 | -2.75265 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -2.73816 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -2.72924 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -2.68598 |
| SELL | selectin L | -2.66322 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -2.66169 |
| E2F6 | E2F transcription factor 6 | -2.62196 |
| IFI30 | interferon, gamma-inducible protein 30 | -2.56079 |
| STN1 | STN1 subunit of CST complex | -2.53759 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | -2.45523 |
| CSRNP2 | cysteine-serine-rich nuclear protein 2 | -2.45204 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | -2.43969 |
| CLOCK | clock circadian regulator | -2.36439 |
| TTC4 | tetratricopeptide repeat domain 4 | -2.3444 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -2.30517 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -2.30004 |
| KRT19 | keratin 19, type I | -2.2894 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -2.28268 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -2.28181 |
| LDHC | lactate dehydrogenase C | -2.26827 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -2.26636 |
| HEATR1 | HEAT repeat containing 1 | -2.25603 |
| BST2 | bone marrow stromal cell antigen 2 | -2.25218 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | -2.24507 |
| APOL6 | apolipoprotein L, 6 | -2.23905 |
| GLUL | glutamate-ammonia ligase | -2.23405 |
| AK4 | adenylate kinase 4 | -2.20028 |
| INSIG2 | insulin induced gene 2 | -2.19756 |
| EMC6 | ER membrane protein complex subunit 6 | -2.19194 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | -2.18774 |
| MED28 | mediator complex subunit 28 | -2.17139 |
| XKR8 | XK, Kell blood group complex subunit-related family, member 8 | -2.16458 |
| SKAP2 | src kinase associated phosphoprotein 2 | -2.1613 |
| WDR37 | WD repeat domain 37 | -2.13794 |
| PIGV | phosphatidylinositol glycan anchor biosynthesis, class V | -2.12428 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | -2.12329 |
| KIF3B | kinesin family member 3B | -2.12315 |
| WASF2 | WAS protein family, member 2 | -2.08884 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -2.08824 |
| PLAAT4 | phospholipase A and acyltransferase 4 | -2.08153 |
| DRC11 | dynein regulatory complex subunit 11 | -2.07304 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | -2.07118 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -2.05872 |
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | -2.055 |
| GRN | granulin | -2.04782 |
| RNF34 | ring finger protein 34, E3 ubiquitin protein ligase | -2.04762 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -2.03567 |
| ZXDC | ZXD family zinc finger C | -2.02874 |
| PCBP1 | poly(rC) binding protein 1 | -2.02162 |
| FCGR1A | Fc fragment of IgG, high affinity Ia, receptor (CD64) | -2.01893 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -2.01539 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -2.01302 |
