CRCGN015_MCF10A_48H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 99.96 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN015_MCF10A_48H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 7.3094
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 5.0
CHMP6 charged multivesicular body protein 6 4.57235
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.45305
HMOX1 heme oxygenase 1 4.12895
MINDY1 MINDY lysine 48 deubiquitinase 1 3.4771
PGCKA1 PDCD10 and GCKIII kinases associated 1 3.39635
METRN meteorin, glial cell differentiation regulator 3.30325
ELF4 E74-like factor 4 (ets domain transcription factor) 2.89865
VAMP8 vesicle-associated membrane protein 8 2.8693
ELMO3 engulfment and cell motility 3 2.8542
ADGRD2 adhesion G protein-coupled receptor D2 2.8175
IL17RB interleukin 17 receptor B 2.8035
UXS1 UDP-glucuronate decarboxylase 1 2.66875
SCRN1 secernin 1 2.65825
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.6418
WIPF2 WAS/WASL interacting protein family, member 2 2.57137
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.543
ANAPC10 anaphase promoting complex subunit 10 2.53465
AXIN1 axin 1 2.51295
NUBP2 nucleotide binding protein 2 2.49485
CLCNKB chloride channel, voltage-sensitive Kb 2.47945
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.4754
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.4745
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.47275
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.42525
GRAMD2B GRAM domain containing 2B 2.40495
OSGEP O-sialoglycoprotein endopeptidase 2.38175
FXYD2 FXYD domain containing ion transport regulator 2 2.37245
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.36125
TET3 tet methylcytosine dioxygenase 3 2.34665
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.3145
CATSPERH catsper channel auxiliary subunit eta 2.29675
IL13 interleukin 13 2.2802
CERS2 ceramide synthase 2 2.27425
SLC43A3 solute carrier family 43, member 3 2.26757
UGT8 UDP glycosyltransferase 8 2.2672
MOK MOK protein kinase 2.2558
PRSS58 protease, serine, 58 2.2451
DNASE1 deoxyribonuclease I 2.2196
NPIPB6 nuclear pore complex interacting protein family, member B6 2.21515
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.21232
ZNF787 zinc finger protein 787 2.2122
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.21173
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.2017
CCL17 chemokine (C-C motif) ligand 17 2.2004
CTRC chymotrypsin C (caldecrin) 2.1996
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.16155
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.15445
CTRL chymotrypsin-like 2.13935
LYRM9 LYR motif containing 9 2.1284
PDCD1 programmed cell death 1 2.12575
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.1252
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.12465
AMN amnion associated transmembrane protein 2.1246
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.1157
CEP131 centrosomal protein 131kDa 2.1135
MCTP2 multiple C2 domains, transmembrane 2 2.10485
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.103
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.10225
CD70 CD70 molecule 2.0937
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.0881
ITPKA inositol-trisphosphate 3-kinase A 2.08485
GPR171 G protein-coupled receptor 171 2.07835
MPC1 mitochondrial pyruvate carrier 1 2.0715
HBA1 hemoglobin, alpha 1 2.07039
PARK7 parkinson protein 7 2.0689
GCN1 GCN1 activator of EIF2AK4 2.0645
LCMT1 leucine carboxyl methyltransferase 1 2.06015
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.05945
CA2 carbonic anhydrase II 2.0592
PKM pyruvate kinase, muscle 2.05305
REG1A regenerating islet-derived 1 alpha 2.0467
SH3BP1 SH3-domain binding protein 1 2.04655
PDE8A phosphodiesterase 8A 2.0396
A1CF APOBEC1 complementation factor 2.0292
BIRC3 baculoviral IAP repeat containing 3 2.02745
KLK1 kallikrein 1 2.02365
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.02305
ADORA1 adenosine A1 receptor 2.01573
DCTPP1 dCTP pyrophosphatase 1 2.014
SCTR secretin receptor 2.01055
MAN2C1 mannosidase, alpha, class 2C, member 1 2.0084
PYDC1 PYD (pyrin domain) containing 1 2.0054
NINJ2 ninjurin 2 2.0016
PRR13 proline rich 13 2.00115

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.5507
TUBB6 tubulin, beta 6 class V -5.4509
SNX7 sorting nexin 7 -5.2708
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.92555
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.49237
YME1L1 YME1-like 1 ATPase -4.44675
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.3403
S100A8 S100 calcium binding protein A8 -3.8041
VIM vimentin -3.65945
MRPS2 mitochondrial ribosomal protein S2 -3.6008
MT2A metallothionein 2A -2.99265
RAI14 retinoic acid induced 14 -2.91385
KLF10 Kruppel-like factor 10 -2.7844
OAT ornithine aminotransferase -2.72425
IRF1 interferon regulatory factor 1 -2.63655
TM9SF3 transmembrane 9 superfamily member 3 -2.5993
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.5942
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -2.5795
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.51315
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.4675
PAIP1 poly(A) binding protein interacting protein 1 -2.36086
ABI1 abl-interactor 1 -2.31768
DACH1 dachshund family transcription factor 1 -2.30795
ICE1 interactor of little elongation complex ELL subunit 1 -2.307
FASTKD5 FAST kinase domains 5 -2.29195
ANXA3 annexin A3 -2.26965
RLF rearranged L-myc fusion -2.2615
SCAP SREBF chaperone -2.2609
NELFB negative elongation factor complex member B -2.25095
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.1918
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.187
DROSHA drosha, ribonuclease type III -2.18225
PDCD6IP programmed cell death 6 interacting protein -2.14885
HEBP1 heme binding protein 1 -2.1085
EXOC1 exocyst complex component 1 -2.1062
AHNAK2 AHNAK nucleoprotein 2 -2.04775
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.046
C1QB complement component 1, q subcomponent, B chain -2.04335
DNTT DNA nucleotidylexotransferase -2.0387
CSRP2 cysteine and glycine-rich protein 2 -2.01575
MFAP2 microfibrillar-associated protein 2 -2.00315