CRCGN015_MCF10A_48H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methenamine 33.49 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN015_MCF10A_48H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 3.46436
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.19921
PPARG peroxisome proliferator-activated receptor gamma 2.97476
SCRN1 secernin 1 2.96715
RPL18 ribosomal protein L18 2.95687
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.93314
HYOU1 hypoxia up-regulated 1 2.85192
UBB ubiquitin B 2.5902
RPS29 ribosomal protein S29 2.55297
PTGFR prostaglandin F receptor (FP) 2.54924
ENOSF1 enolase superfamily member 1 2.49531
RPL27A ribosomal protein L27a 2.39583
RPL32 ribosomal protein L32 2.33934
RPS11 ribosomal protein S11 2.33854
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.32009
RPS25 ribosomal protein S25 2.30818
RPS19 ribosomal protein S19 2.3052
CHEK2 checkpoint kinase 2 2.28356
RPL9 ribosomal protein L9 2.28001
RPS10 ribosomal protein S10 2.27508
KLHDC4 kelch domain containing 4 2.25901
RPL34 ribosomal protein L34 2.24511
RPL4 ribosomal protein L4 2.23005
RPL8 ribosomal protein L8 2.21473
RPLP2 ribosomal protein, large, P2 2.20372
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.18364
SNRPG small nuclear ribonucleoprotein polypeptide G 2.14788
TPT1 tumor protein, translationally-controlled 1 2.13694
RPL38 ribosomal protein L38 2.13541
RPS16 ribosomal protein S16 2.13343
RPL27 ribosomal protein L27 2.12465
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.11674
RPS18 ribosomal protein S18 2.11652
RPS3A ribosomal protein S3A 2.11384
RPL41 ribosomal protein L41 2.10146
COMMD1 copper metabolism (Murr1) domain containing 1 2.09886
RPL23A ribosomal protein L23a 2.09729
RPL12 ribosomal protein L12 2.09407
RPLP1 ribosomal protein, large, P1 2.09105
MTCH2 mitochondrial carrier 2 2.06237
RPS4X ribosomal protein S4, X-linked 2.05513
RPL21 ribosomal protein L21 2.04852
RPS12 ribosomal protein S12 2.04504
PHB2 prohibitin 2 2.04411
DAZAP1 DAZ associated protein 1 2.04078
RPL30 ribosomal protein L30 2.03419
RPL7A ribosomal protein L7a 2.02451
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 2.01982
ATP5F1D ATP synthase F1 subunit delta 2.0078
RPS15A ribosomal protein S15a 2.0026

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -6.62297
KRT14 keratin 14, type I -4.20683
MSMO1 methylsterol monooxygenase 1 -3.41551
ATG4A autophagy related 4A, cysteine peptidase -3.108
PDLIM1 PDZ and LIM domain 1 -2.90665
GNPAT glyceronephosphate O-acyltransferase -2.45108
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.44233
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.38228
PODXL podocalyxin-like -2.31344
RBM41 RNA binding motif protein 41 -2.27399
FN1 fibronectin 1 -2.27244
SMYD3 SET and MYND domain containing 3 -2.26771
GGPS1 geranylgeranyl diphosphate synthase 1 -2.19183
TXNRD1 thioredoxin reductase 1 -2.1642
WWC1 WW and C2 domain containing 1 -2.13819
MORF4L2 mortality factor 4 like 2 -2.09684
S100A8 S100 calcium binding protein A8 -2.09185
KRT7 keratin 7, type II -2.08283
HEG1 heart development protein with EGF-like domains 1 -2.00806
SNRPN small nuclear ribonucleoprotein polypeptide N -2.00427