CRCGN015_MCF10A_48H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 33.66 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

17 genes differentially expressed following the CRCGN015_MCF10A_48H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 4.88136
MAP2K5 mitogen-activated protein kinase kinase 5 3.96621
SIRT3 sirtuin 3 3.10878
CDT1 chromatin licensing and DNA replication factor 1 2.21275
TESK1 testis-specific kinase 1 2.18367
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.1307
WDR7 WD repeat domain 7 2.08096
RIC8A RIC8 guanine nucleotide exchange factor A 2.01185
CD1B CD1b molecule 2.00338

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.87218
KRT7 keratin 7, type II -2.77706
ISOC1 isochorismatase domain containing 1 -2.32995
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.28827
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.1586
GAA glucosidase, alpha; acid -2.10953
BTBD3 BTB (POZ) domain containing 3 -2.08556
MT2A metallothionein 2A -2.01159