CRCGN015_MCF10A_48H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 11.22 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_MCF10A_48H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GRWD1 glutamate-rich WD repeat containing 1 3.13055
PRKCQ protein kinase C, theta 3.12698
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.05741
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.71049
FBXL12 F-box and leucine-rich repeat protein 12 2.68568
TMEM50A transmembrane protein 50A 2.14357
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.12903
BCCIP BRCA2 and CDKN1A interacting protein 2.05869

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.61191
SUMO4 small ubiquitin-like modifier 4 -3.21628
KRT14 keratin 14, type I -3.1386
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.98962
TXNDC9 thioredoxin domain containing 9 -2.8721
HSPA8 heat shock 70kDa protein 8 -2.86491
JPT1 Jupiter microtubule associated homolog 1 -2.70487
VIM vimentin -2.63631
SAP30BP SAP30 binding protein -2.62508
RPL39L ribosomal protein L39-like -2.60235
KCTD2 potassium channel tetramerization domain containing 2 -2.51042
MRPL58 mitochondrial ribosomal protein L58 -2.5103
PDCL3 phosducin-like 3 -2.38279
RAB4A RAB4A, member RAS oncogene family -2.27643
CASKIN2 CASK interacting protein 2 -2.27145
NUP85 nucleoporin 85kDa -2.24186
EVPL envoplakin -2.23809
REV1 REV1, polymerase (DNA directed) -2.21128
TMEM94 transmembrane protein 94 -2.1363
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.04505
MRPS7 mitochondrial ribosomal protein S7 -2.02931