CRCGN015_MCF10A_48H:E13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bisphenol-a 99.96 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

249 genes differentially expressed following the CRCGN015_MCF10A_48H:E13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DUSP6 dual specificity phosphatase 6 5.13368
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.19795
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 4.01209
WIF1 WNT inhibitory factor 1 3.876
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.84293
HMGA2 high mobility group AT-hook 2 3.74387
CCDC92 coiled-coil domain containing 92 3.70374
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3.6675
CTSL cathepsin L 3.65735
NRIP1 nuclear receptor interacting protein 1 3.59826
SOX4 SRY (sex determining region Y)-box 4 3.55041
GRN granulin 3.50398
ABHD6 abhydrolase domain containing 6 3.41194
TMEM50A transmembrane protein 50A 3.3724
LAGE3 L antigen family, member 3 3.35566
PYGL phosphorylase, glycogen, liver 3.29752
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.2863
NAGK N-acetylglucosamine kinase 3.25878
GFPT1 glutamine--fructose-6-phosphate transaminase 1 3.19233
KIFBP kinesin family binding protein 3.18641
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 3.09967
GRB10 growth factor receptor-bound protein 10 3.09697
SPG11 spastic paraplegia 11 (autosomal recessive) 3.09056
CARS1 cysteinyl-tRNA synthetase 1 2.89172
DYNLT3 dynein, light chain, Tctex-type 3 2.89071
IER3 immediate early response 3 2.81739
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.71287
FHL2 four and a half LIM domains 2 2.70228
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.69025
COPB1 coatomer protein complex, subunit beta 1 2.60537
CIRBP cold inducible RNA binding protein 2.59533
ELAC2 elaC ribonuclease Z 2 2.58943
NMRK1 nicotinamide riboside kinase 1 2.58216
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.56258
GPX4 glutathione peroxidase 4 2.56069
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.54902
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.52799
NUCB2 nucleobindin 2 2.52396
GDI1 GDP dissociation inhibitor 1 2.52202
ARMCX2 armadillo repeat containing, X-linked 2 2.50505
RABAC1 Rab acceptor 1 (prenylated) 2.47243
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.47021
GARS1 glycyl-tRNA synthetase 1 2.45279
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.44305
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.42621
OSTF1 osteoclast stimulating factor 1 2.39544
CLCA2 chloride channel accessory 2 2.37146
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.36165
GLRX glutaredoxin (thioltransferase) 2.35492
PLAUR plasminogen activator, urokinase receptor 2.33645
GABARAP GABA(A) receptor-associated protein 2.33109
CCS copper chaperone for superoxide dismutase 2.31818
SV2B synaptic vesicle glycoprotein 2B 2.3118
FOSL1 FOS-like antigen 1 2.31034
MACF1 microtubule-actin crosslinking factor 1 2.30075
CALCOCO1 calcium binding and coiled-coil domain 1 2.29987
VAT1 vesicle amine transport 1 2.29405
HDLBP high density lipoprotein binding protein 2.28226
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.27845
AARS1 alanyl-tRNA synthetase 1 2.27136
RTCA RNA 3'-terminal phosphate cyclase 2.27016
EIF4A2 eukaryotic translation initiation factor 4A2 2.23005
DUSP10 dual specificity phosphatase 10 2.20964
TM9SF2 transmembrane 9 superfamily member 2 2.20748
TEX264 testis expressed 264 2.20291
YIPF3 Yip1 domain family, member 3 2.16798
CALU calumenin 2.15585
CEPT1 choline/ethanolamine phosphotransferase 1 2.15252
STX1A syntaxin 1A (brain) 2.14575
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.14559
TALDO1 transaldolase 1 2.13495
GALE UDP-galactose-4-epimerase 2.13451
UBA1 ubiquitin-like modifier activating enzyme 1 2.1345
CDC34 cell division cycle 34 2.12969
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.12889
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.12873
DUSP4 dual specificity phosphatase 4 2.121
ARMCX3 armadillo repeat containing, X-linked 3 2.12047
RNF187 ring finger protein 187 2.11898
ST18 suppression of tumorigenicity 18, zinc finger 2.1188
HBA1 hemoglobin, alpha 1 2.11872
LYPD3 LY6/PLAUR domain containing 3 2.11165
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.10662
ACOX2 acyl-CoA oxidase 2, branched chain 2.10314
TMEM214 transmembrane protein 214 2.09116
PGPEP1 pyroglutamyl-peptidase I 2.08404
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.0821
PKP1 plakophilin 1 2.0755
PLAU plasminogen activator, urokinase 2.07287
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.07269
CTSF cathepsin F 2.06985
CHPF2 chondroitin polymerizing factor 2 2.06775
TAC4 tachykinin 4 (hemokinin) 2.06186
LARP6 La ribonucleoprotein domain family, member 6 2.06159
MLPH melanophilin 2.05983
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.04099
EN2 engrailed homeobox 2 2.03898
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.03593
FAM114A1 family with sequence similarity 114, member A1 2.01329
ULBP2 UL16 binding protein 2 2.01059
STK25 serine/threonine kinase 25 2.01016
CYB5R2 cytochrome b5 reductase 2 2.00961
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.00697
MZB1 marginal zone B and B1 cell-specific protein 2.00344

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -10.0
PLS1 plastin 1 -4.68215
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.24053
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.16489
RGS2 regulator of G-protein signaling 2 -3.89586
PUF60 poly-U binding splicing factor 60KDa -3.5168
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.47421
CDC20 cell division cycle 20 -3.40572
CCNB2 cyclin B2 -3.39353
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.37838
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -3.21732
TOP2A topoisomerase (DNA) II alpha 170kDa -3.20684
ZNF16 zinc finger protein 16 -3.16056
HMGB2 high mobility group box 2 -3.15621
BIRC5 baculoviral IAP repeat containing 5 -3.0955
FOXJ3 forkhead box J3 -3.07829
TUBB6 tubulin, beta 6 class V -3.04184
SESN1 sestrin 1 -2.97399
NOP16 NOP16 nucleolar protein -2.93806
KIF14 kinesin family member 14 -2.89972
SNRPE small nuclear ribonucleoprotein polypeptide E -2.89364
FOXM1 forkhead box M1 -2.87882
MVD mevalonate (diphospho) decarboxylase -2.87657
PCCB propionyl CoA carboxylase, beta polypeptide -2.87082
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.86357
INSIG1 insulin induced gene 1 -2.85957
PRR15L proline rich 15-like -2.81253
CCNA2 cyclin A2 -2.77588
ARHGAP15 Rho GTPase activating protein 15 -2.76778
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.7653
THSD7A thrombospondin, type I, domain containing 7A -2.75571
MELK maternal embryonic leucine zipper kinase -2.74799
SETD1A SET domain containing 1A -2.73884
BLMH bleomycin hydrolase -2.73695
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.71912
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.68392
ISOC1 isochorismatase domain containing 1 -2.67598
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.6728
RUVBL1 RuvB-like AAA ATPase 1 -2.67073
FJX1 four jointed box 1 (Drosophila) -2.65992
ADRB2 adrenoceptor beta 2, surface -2.6286
IPO4 importin 4 -2.62628
SNX7 sorting nexin 7 -2.62601
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.62586
SMNDC1 survival motor neuron domain containing 1 -2.61618
EBNA1BP2 EBNA1 binding protein 2 -2.60235
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.5939
ELOVL6 ELOVL fatty acid elongase 6 -2.58898
ZCCHC10 zinc finger, CCHC domain containing 10 -2.57387
MRPL11 mitochondrial ribosomal protein L11 -2.57151
CDC25B cell division cycle 25B -2.55949
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.54865
NDC80 NDC80 kinetochore complex component -2.53784
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.5331
TWNK twinkle mtDNA helicase -2.52867
GCH1 GTP cyclohydrolase 1 -2.50945
SEH1L SEH1-like (S. cerevisiae) -2.50715
CEMIP2 cell migration inducing hyaluronidase 2 -2.50337
MAK16 MAK16 homolog (S. cerevisiae) -2.48995
KIF18B kinesin family member 18B -2.46451
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.45007
CCNC cyclin C -2.44152
FXN frataxin -2.43538
MLH1 mutL homolog 1 -2.42596
TEAD4 TEA domain family member 4 -2.41672
FBL fibrillarin -2.41644
DCK deoxycytidine kinase -2.40879
KIF11 kinesin family member 11 -2.39023
CTBP2 C-terminal binding protein 2 -2.38153
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.36293
PNPO pyridoxamine 5'-phosphate oxidase -2.36072
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.3534
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.34386
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.34332
SOAT2 sterol O-acyltransferase 2 -2.34076
NOP14 NOP14 nucleolar protein -2.32969
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.32493
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.32443
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.31473
SCRIB scribbled planar cell polarity protein -2.30963
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.3093
SPC25 SPC25, NDC80 kinetochore complex component -2.29803
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.29592
CDC25C cell division cycle 25C -2.29591
BRIX1 BRX1, biogenesis of ribosomes -2.29528
ZNF35 zinc finger protein 35 -2.28488
TMOD1 tropomodulin 1 -2.27779
LBR lamin B receptor -2.27374
PBK PDZ binding kinase -2.27243
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.26808
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.24139
CD24 CD24 molecule -2.23363
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.23352
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -2.22993
ESRP2 epithelial splicing regulatory protein 2 -2.22954
CDX2 caudal type homeobox 2 -2.21473
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.21042
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.20913
CAAP1 caspase activity and apoptosis inhibitor 1 -2.19377
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.19002
ZNF26 zinc finger protein 26 -2.1852
ENOPH1 enolase-phosphatase 1 -2.18044
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.17935
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.16432
GGT5 gamma-glutamyltransferase 5 -2.15981
CDC23 cell division cycle 23 -2.15683
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.1524
SPAG1 sperm associated antigen 1 -2.14933
ZNF263 zinc finger protein 263 -2.14411
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.13801
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.13788
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.13271
NAT10 N-acetyltransferase 10 (GCN5-related) -2.13254
PAK1IP1 PAK1 interacting protein 1 -2.12753
PLAC8 placenta-specific 8 -2.12154
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -2.11733
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.11479
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.10434
LINS1 lines homolog 1 -2.10087
GLI1 GLI family zinc finger 1 -2.09586
TCEAL1 transcription elongation factor A (SII)-like 1 -2.09375
TTK TTK protein kinase -2.09186
PLK1 polo-like kinase 1 -2.08454
SPON1 spondin 1, extracellular matrix protein -2.08279
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.08113
SCML1 sex comb on midleg-like 1 (Drosophila) -2.07311
SOD3 superoxide dismutase 3, extracellular -2.07304
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.07028
RPA3 replication protein A3, 14kDa -2.06746
NDC1 NDC1 transmembrane nucleoporin -2.06149
GEMIN2 gem (nuclear organelle) associated protein 2 -2.05595
AGO2 argonaute RISC catalytic component 2 -2.04315
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.04275
KIF20A kinesin family member 20A -2.03942
TTC12 tetratricopeptide repeat domain 12 -2.03062
DBF4 DBF4 zinc finger -2.02816
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.02614
CETN3 centrin, EF-hand protein, 3 -2.02554
PRMT1 protein arginine methyltransferase 1 -2.02529
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.02367
TOMM34 translocase of outer mitochondrial membrane 34 -2.01588
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.01572
DCAF17 DDB1 and CUL4 associated factor 17 -2.015
PEX3 peroxisomal biogenesis factor 3 -2.01196
PARPBP PARP1 binding protein -2.00591