CRCGN015_MCF10A_48H:E16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 100.46 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

202 genes differentially expressed following the CRCGN015_MCF10A_48H:E16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 6.01271
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.51277
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.08389
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.932
CDPF1 cysteine-rich, DPF motif domain containing 1 3.91578
CDC45 cell division cycle 45 3.73203
PYCR1 pyrroline-5-carboxylate reductase 1 3.63022
ANO10 anoctamin 10 3.62384
RBM15B RNA binding motif protein 15B 3.34903
EGR1 early growth response 1 3.27816
DUSP6 dual specificity phosphatase 6 3.27469
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.2296
NUCB2 nucleobindin 2 3.22795
MYLK myosin light chain kinase 3.20428
GFPT1 glutamine--fructose-6-phosphate transaminase 1 3.06436
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.05633
SNAP29 synaptosomal-associated protein, 29kDa 3.02296
COPZ2 coatomer protein complex, subunit zeta 2 2.89468
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.87796
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.87268
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.87086
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.81385
PTK2B protein tyrosine kinase 2 beta 2.73171
ATF3 activating transcription factor 3 2.67532
CARS1 cysteinyl-tRNA synthetase 1 2.61441
DPP3 dipeptidyl-peptidase 3 2.60804
CHIC2 cysteine-rich hydrophobic domain 2 2.55963
METTL25B methyltransferase like 25B 2.54844
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.50232
DYNLT3 dynein, light chain, Tctex-type 3 2.48936
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.47577
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.45552
THAP7 THAP domain containing 7 2.45278
TGIF1 TGFB-induced factor homeobox 1 2.45155
BLVRB biliverdin reductase B 2.44149
CCS copper chaperone for superoxide dismutase 2.4277
CCNA1 cyclin A1 2.40661
KCMF1 potassium channel modulatory factor 1 2.40289
SQSTM1 sequestosome 1 2.38221
SUGCT succinyl-CoA:glutarate-CoA transferase 2.37185
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.37176
SULF1 sulfatase 1 2.35948
GARS1 glycyl-tRNA synthetase 1 2.34507
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.34387
S100A4 S100 calcium binding protein A4 2.33112
BDKRB2 bradykinin receptor B2 2.31007
GDF15 growth differentiation factor 15 2.30286
OVOL2 ovo-like zinc finger 2 2.2952
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.28115
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.26389
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.26075
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.24144
CIB1 calcium and integrin binding 1 (calmyrin) 2.21811
HDLBP high density lipoprotein binding protein 2.20727
IER3 immediate early response 3 2.20631
LOC128125814 uncharacterized LOC128125814 2.19896
HBEGF heparin-binding EGF-like growth factor 2.19102
GRWD1 glutamate-rich WD repeat containing 1 2.16598
ANO1 anoctamin 1, calcium activated chloride channel 2.16569
EGR3 early growth response 3 2.16013
STBD1 starch binding domain 1 2.15302
ATP9A ATPase, class II, type 9A 2.1359
DDB2 damage-specific DNA binding protein 2, 48kDa 2.13162
RTCA RNA 3'-terminal phosphate cyclase 2.11323
SPHK1 sphingosine kinase 1 2.11318
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.11139
ZC2HC1A zinc finger, C2HC-type containing 1A 2.10765
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.09359
FAM114A1 family with sequence similarity 114, member A1 2.08643
WDR11 WD repeat domain 11 2.07892
GMPPA GDP-mannose pyrophosphorylase A 2.05356
BCL2L2 BCL2-like 2 2.05197
DGCR6L DiGeorge syndrome critical region gene 6-like 2.04792
PLK3 polo-like kinase 3 2.04025
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.0384
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.02975
TTC17 tetratricopeptide repeat domain 17 2.01945
SLC67A1 solute carrier family 67 member 1 2.01566
TGFBI transforming growth factor, beta-induced, 68kDa 2.01522
PYGB phosphorylase, glycogen; brain 2.01037

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.89732
S100A8 S100 calcium binding protein A8 -4.27623
FOXJ3 forkhead box J3 -3.98425
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.61646
CDC20 cell division cycle 20 -3.48326
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.32871
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.20779
TWNK twinkle mtDNA helicase -3.14465
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -3.06102
HSPA1A heat shock 70kDa protein 1A -3.05604
LDHB lactate dehydrogenase B -2.94581
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.94564
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.94337
BIRC5 baculoviral IAP repeat containing 5 -2.91462
PLK1 polo-like kinase 1 -2.909
DNAAF2 dynein, axonemal, assembly factor 2 -2.88776
KIF20A kinesin family member 20A -2.86475
RUVBL1 RuvB-like AAA ATPase 1 -2.86265
CCNA2 cyclin A2 -2.81789
CCNB2 cyclin B2 -2.77067
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.76773
KIF11 kinesin family member 11 -2.76673
STMN1 stathmin 1 -2.74916
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.73962
REEP5 receptor accessory protein 5 -2.69799
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.6573
HADH hydroxyacyl-CoA dehydrogenase -2.6519
PRRC2A proline-rich coiled-coil 2A -2.63548
C1QBP complement component 1, q subcomponent binding protein -2.63091
SERF1A small EDRK-rich factor 1A (telomeric) -2.62991
SMNDC1 survival motor neuron domain containing 1 -2.59078
ATP11B ATPase, class VI, type 11B -2.57778
SPATA5L1 spermatogenesis associated 5-like 1 -2.5707
PFAS phosphoribosylformylglycinamidine synthase -2.56833
SLC35F2 solute carrier family 35, member F2 -2.55505
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.53985
NDC1 NDC1 transmembrane nucleoporin -2.50237
PHACTR4 phosphatase and actin regulator 4 -2.49855
SOAT2 sterol O-acyltransferase 2 -2.49248
BZW2 basic leucine zipper and W2 domains 2 -2.4756
NOL8 nucleolar protein 8 -2.47055
NOP16 NOP16 nucleolar protein -2.46992
TM9SF3 transmembrane 9 superfamily member 3 -2.46413
ZNF227 zinc finger protein 227 -2.43927
CD320 CD320 molecule -2.42763
DEPDC1 DEP domain containing 1 -2.42378
MED17 mediator complex subunit 17 -2.42327
PPID peptidylprolyl isomerase D -2.4205
MRPS2 mitochondrial ribosomal protein S2 -2.41715
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.41437
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.40859
SINHCAF SIN3-HDAC complex associated factor -2.40797
PRMT1 protein arginine methyltransferase 1 -2.40251
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.39939
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.37162
SRSF2 serine/arginine-rich splicing factor 2 -2.36725
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.35371
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.35155
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -2.34925
TMOD3 tropomodulin 3 (ubiquitous) -2.33569
SNRPF small nuclear ribonucleoprotein polypeptide F -2.32368
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.28978
WDR3 WD repeat domain 3 -2.28684
FBL fibrillarin -2.26684
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.26421
KIF18B kinesin family member 18B -2.25364
NCAPD3 non-SMC condensin II complex, subunit D3 -2.24134
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.23877
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -2.23364
CDC25B cell division cycle 25B -2.23314
EIF3E eukaryotic translation initiation factor 3, subunit E -2.21601
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.20707
TMEM109 transmembrane protein 109 -2.19916
ZMPSTE24 zinc metallopeptidase STE24 -2.19336
RPL35 ribosomal protein L35 -2.1726
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.16793
WDCP WD repeat and coiled coil containing -2.16286
TTK TTK protein kinase -2.15021
WDR43 WD repeat domain 43 -2.14931
TTC27 tetratricopeptide repeat domain 27 -2.14725
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.14499
VBP1 von Hippel-Lindau binding protein 1 -2.14335
UBE2C ubiquitin-conjugating enzyme E2C -2.14139
EXOSC9 exosome component 9 -2.14067
MDN1 MDN1, midasin homolog (yeast) -2.13057
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.13015
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.12709
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.12662
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.12103
WASF1 WAS protein family, member 1 -2.11487
TUBD1 tubulin, delta 1 -2.11217
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.10077
GEMIN2 gem (nuclear organelle) associated protein 2 -2.09034
LIFR leukemia inhibitory factor receptor alpha -2.0873
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.0848
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.08301
EVL Enah/Vasp-like -2.08101
FBXO3 F-box protein 3 -2.07346
BBS10 Bardet-Biedl syndrome 10 -2.07211
SLIRP SRA stem-loop interacting RNA binding protein -2.07068
MBNL2 muscleblind-like splicing regulator 2 -2.07066
NLGN4X neuroligin 4, X-linked -2.06771
PNPO pyridoxamine 5'-phosphate oxidase -2.06338
CETN3 centrin, EF-hand protein, 3 -2.06334
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.06273
TFB2M transcription factor B2, mitochondrial -2.05659
ATP5F1A ATP synthase F1 subunit alpha -2.05319
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.0515
HDAC2 histone deacetylase 2 -2.04691
JPT1 Jupiter microtubule associated homolog 1 -2.0385
MED6 mediator complex subunit 6 -2.03324
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 -2.03211
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.01839
UTRN utrophin -2.01758
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.0155
KDM1A lysine (K)-specific demethylase 1A -2.01314
SEPHS1 selenophosphate synthetase 1 -2.01147
RPL36 ribosomal protein L36 -2.00654
PBK PDZ binding kinase -2.00169
LGALS14 lectin, galactoside-binding, soluble, 14 -2.00135
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.00102
CCNC cyclin C -2.00018