CRCGN015_MCF10A_48H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 33.49 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

273 genes differentially expressed following the CRCGN015_MCF10A_48H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 4.93405
BZW2 basic leucine zipper and W2 domains 2 4.8491
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 4.84155
ABHD4 abhydrolase domain containing 4 4.4707
EAPP E2F-associated phosphoprotein 4.0918
PTK2B protein tyrosine kinase 2 beta 3.69465
IGHMBP2 immunoglobulin mu binding protein 2 3.54025
HYOU1 hypoxia up-regulated 1 3.1391
EPN2 epsin 2 3.03805
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.01113
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.0038
ZNF778 zinc finger protein 778 2.9785
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.89635
WIF1 WNT inhibitory factor 1 2.81835
FNDC8 fibronectin type III domain containing 8 2.8041
ADGRB3 adhesion G protein-coupled receptor B3 2.77755
PAX9 paired box 9 2.7332
PGAM2 phosphoglycerate mutase 2 (muscle) 2.67735
BEGAIN brain-enriched guanylate kinase-associated 2.6587
CD63 CD63 molecule 2.63245
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.605
NKX2-8 NK2 homeobox 8 2.5817
TLX1 T-cell leukemia homeobox 1 2.58085
YBX2 Y box binding protein 2 2.57465
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.54475
PGK2 phosphoglycerate kinase 2 2.5289
NPAS1 neuronal PAS domain protein 1 2.52418
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 2.51905
TRIB1 tribbles pseudokinase 1 2.5144
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 2.496
FAM234B family with sequence similarity 234 member B 2.48055
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.47545
CTNND2 catenin (cadherin-associated protein), delta 2 2.46662
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.45535
NAP1L2 nucleosome assembly protein 1-like 2 2.45455
TLL2 tolloid-like 2 2.44437
NECAB2 N-terminal EF-hand calcium binding protein 2 2.4372
SMN2 survival of motor neuron 2, centromeric 2.4312
ANKRD7 ankyrin repeat domain 7 2.43045
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.41955
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.3956
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.39267
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.3898
JUN jun proto-oncogene 2.3858
SYNPO2L synaptopodin 2-like 2.3836
WNT10B wingless-type MMTV integration site family, member 10B 2.3729
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.3716
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.36205
VWA7 von Willebrand factor A domain containing 7 2.36115
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.35605
LMCD1 LIM and cysteine-rich domains 1 2.35515
ARHGAP5 Rho GTPase activating protein 5 2.34795
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.34355
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.3331
TNP1 transition protein 1 (during histone to protamine replacement) 2.3305
FBXO24 F-box protein 24 2.32825
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.3273
CORO1A coronin, actin binding protein, 1A 2.32195
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.3214
THBS4 thrombospondin 4 2.3145
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.30785
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.3069
GAP43 growth associated protein 43 2.30623
KLHL26 kelch-like family member 26 2.30135
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.29095
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.28985
SLC35F6 solute carrier family 35, member F6 2.2761
CFAP46 cilia and flagella associated protein 46 2.27225
FOXB1 forkhead box B1 2.2711
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.2614
BARX1 BARX homeobox 1 2.25535
PITX3 paired-like homeodomain 3 2.2507
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.25015
MEIS2 Meis homeobox 2 2.2445
ADGRL1 adhesion G protein-coupled receptor L1 2.24418
SCG3 secretogranin III 2.24355
SIX3 SIX homeobox 3 2.2434
PDLIM3 PDZ and LIM domain 3 2.24227
WIPF2 WAS/WASL interacting protein family, member 2 2.23707
GLP2R glucagon-like peptide 2 receptor 2.23645
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.23605
GDAP1 ganglioside induced differentiation associated protein 1 2.2314
SCARA3 scavenger receptor class A, member 3 2.2301
LY6H lymphocyte antigen 6 complex, locus H 2.22875
DRP2 dystrophin related protein 2 2.2198
NLGN3 neuroligin 3 2.21705
GPR68 G protein-coupled receptor 68 2.2161
EGR1 early growth response 1 2.20872
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.20635
TBKBP1 TBK1 binding protein 1 2.2056
USP11 ubiquitin specific peptidase 11 2.2038
OPRD1 opioid receptor, delta 1 2.20365
TRIM11 tripartite motif containing 11 2.20285
RGS16 regulator of G-protein signaling 16 2.20257
COL5A3 collagen, type V, alpha 3 2.20128
NTN1 netrin 1 2.20045
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.19582
ZNF365 zinc finger protein 365 2.1952
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.1896
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.1895
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.18145
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.1796
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.17945
GFPT2 glutamine-fructose-6-phosphate transaminase 2 2.17745
CDH20 cadherin 20, type 2 2.1714
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.1642
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.15635
PRLH prolactin releasing hormone 2.15395
NUAK1 NUAK family, SNF1-like kinase, 1 2.15105
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.15085
NPAS3 neuronal PAS domain protein 3 2.15023
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.1444
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.13505
HSPB1 heat shock 27kDa protein 1 2.1313
SPATA31A3 SPATA31 subfamily A, member 3 2.13045
CCDC70 coiled-coil domain containing 70 2.1304
TMEM223 transmembrane protein 223 2.12945
ADAM2 ADAM metallopeptidase domain 2 2.1275
UPK3A uroplakin 3A 2.125
SUSD5 sushi domain containing 5 2.1213
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.11455
GPR63 G protein-coupled receptor 63 2.11295
DOC2A double C2-like domains, alpha 2.11225
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 2.111
PRR7 proline rich 7 (synaptic) 2.10785
HEG1 heart development protein with EGF-like domains 1 2.1072
KCNIP1 Kv channel interacting protein 1 2.10265
ADAM30 ADAM metallopeptidase domain 30 2.1003
RLBP1 retinaldehyde binding protein 1 2.0988
HROB homologous recombination factor with OB-fold 2.09835
DOK2 docking protein 2, 56kDa 2.09795
BFSP1 beaded filament structural protein 1, filensin 2.09595
CAMK4 calcium/calmodulin-dependent protein kinase IV 2.09585
DERL2 derlin 2 2.09415
SOCS3 suppressor of cytokine signaling 3 2.09262
CFAP298 cilia and flagella associated protein 298 2.0896
NMRK2 nicotinamide riboside kinase 2 2.08695
NOSIP nitric oxide synthase interacting protein 2.0854
PANX1 pannexin 1 2.0823
GLRA1 glycine receptor, alpha 1 2.0787
SARAF store-operated calcium entry-associated regulatory factor 2.07795
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.07525
KDM6B lysine (K)-specific demethylase 6B 2.075
LIMK1 LIM domain kinase 1 2.0744
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.0732
CAPN5 calpain 5 2.07235
FAM174B family with sequence similarity 174, member B 2.07148
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.0708
PYGM phosphorylase, glycogen, muscle 2.0697
KSR1 kinase suppressor of ras 1 2.06413
H2AX H2A.X variant histone 2.06405
ATXN7L1 ataxin 7-like 1 2.06195
TNMD tenomodulin 2.06185
DGKA diacylglycerol kinase, alpha 80kDa 2.06163
ARC activity-regulated cytoskeleton-associated protein 2.0608
TBR1 T-box, brain, 1 2.05925
CABP5 calcium binding protein 5 2.05825
DGKG diacylglycerol kinase, gamma 90kDa 2.0579
CCNJL cyclin J-like 2.0555
CBX2 chromobox homolog 2 2.05365
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.05265
DKKL1 dickkopf-like 1 2.05245
KDM4D lysine (K)-specific demethylase 4D 2.0521
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.0516
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.0511
RERGL RERG/RAS-like 2.05075
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.04985
CCDC181 coiled-coil domain containing 181 2.04805
LPAR4 lysophosphatidic acid receptor 4 2.04585
HPCAL4 hippocalcin like 4 2.04548
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.0448
DPP6 dipeptidyl-peptidase 6 2.0435
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.0416
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 2.03975
STATH statherin 2.03895
MTARC1 mitochondrial amidoxime reducing component 1 2.03745
COX6C cytochrome c oxidase subunit VIc 2.0369
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 2.0365
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.0362
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.03355
FAM131B family with sequence similarity 131, member B 2.0308
NDFIP1 Nedd4 family interacting protein 1 2.02965
SOX21 SRY (sex determining region Y)-box 21 2.028
SV2A synaptic vesicle glycoprotein 2A 2.0252
FICD FIC domain containing 2.02145
ANKRD44 ankyrin repeat domain 44 2.01975
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.0195
EIF4H eukaryotic translation initiation factor 4H 2.0194
LRRN2 leucine rich repeat neuronal 2 2.019
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.01795
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.0166
ATOH1 atonal homolog 1 (Drosophila) 2.01295
EGF epidermal growth factor 2.0125
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.0118
FSCN2 fascin actin-bundling protein 2, retinal 2.01175
SSUH2 ssu-2 homolog (C. elegans) 2.0099
IER2 immediate early response 2 2.0077
FBXL8 F-box and leucine-rich repeat protein 8 2.0073
CHIA chitinase, acidic 2.00545
ACIN1 apoptotic chromatin condensation inducer 1 2.0017
SPATA1 spermatogenesis associated 1 2.0003
SLC35F5 solute carrier family 35, member F5 2.00025

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.46635
NCK1 NCK adaptor protein 1 -5.36662
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.24255
S100A8 S100 calcium binding protein A8 -5.0
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.9184
KRT14 keratin 14, type I -4.46715
SCYL3 SCY1-like 3 (S. cerevisiae) -4.40003
EIF5 eukaryotic translation initiation factor 5 -3.75717
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.51845
TNIP1 TNFAIP3 interacting protein 1 -3.4583
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -3.19145
CDK4 cyclin-dependent kinase 4 -3.09145
DUSP14 dual specificity phosphatase 14 -2.8337
RNF113A ring finger protein 113A -2.80625
GIN1 gypsy retrotransposon integrase 1 -2.72665
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -2.7026
ZBED5 zinc finger, BED-type containing 5 -2.6821
AVEN apoptosis, caspase activation inhibitor -2.6815
BOLA1 bolA family member 1 -2.6728
MRPS15 mitochondrial ribosomal protein S15 -2.5992
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.49663
NUP133 nucleoporin 133kDa -2.4867
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.47195
RNF111 ring finger protein 111 -2.45845
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.43062
ZZZ3 zinc finger, ZZ-type containing 3 -2.4049
RHOT1 ras homolog family member T1 -2.39988
MVP major vault protein -2.3825
NKRF NFKB repressing factor -2.3736
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.35095
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.3392
ALDOC aldolase C, fructose-bisphosphate -2.33625
DDIT4 DNA-damage-inducible transcript 4 -2.3174
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.31705
MAEA macrophage erythroblast attacher -2.31365
SETMAR SET domain and mariner transposase fusion gene -2.3115
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.30855
GTPBP6 GTP binding protein 6 (putative) -2.3055
YAF2 YY1 associated factor 2 -2.29535
TMPRSS11D transmembrane protease, serine 11D -2.26985
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.25805
BIRC3 baculoviral IAP repeat containing 3 -2.24435
MRPL46 mitochondrial ribosomal protein L46 -2.24245
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.2291
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -2.2246
SMAD2 SMAD family member 2 -2.21327
ATG4A autophagy related 4A, cysteine peptidase -2.21175
MCTS1 malignant T cell amplified sequence 1 -2.2058
MGLL monoglyceride lipase -2.20565
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.17265
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 -2.15555
CLCA2 chloride channel accessory 2 -2.14252
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.1348
HMGB3 high mobility group box 3 -2.1273
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.12512
FAM50A family with sequence similarity 50, member A -2.12145
WDR33 WD repeat domain 33 -2.11965
RRAGC Ras-related GTP binding C -2.11865
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.1129
CUEDC2 CUE domain containing 2 -2.0911
TMEM187 transmembrane protein 187 -2.07735
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.0731
IRAK4 interleukin-1 receptor-associated kinase 4 -2.05855
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.05095
CDK8 cyclin-dependent kinase 8 -2.02665
ATP5F1D ATP synthase F1 subunit delta -2.01655
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.0161
PEF1 penta-EF-hand domain containing 1 -2.01335
FAM3A family with sequence similarity 3, member A -2.01315
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.00947
NCBP2 nuclear cap binding protein subunit 2, 20kDa -2.0046