CRCGN015_MCF10A_48H:E21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n??=-diacetylbenzidine 11.36 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

126 genes differentially expressed following the CRCGN015_MCF10A_48H:E21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.31584
SMIM40 small integral membrane protein 40 3.26944
WIF1 WNT inhibitory factor 1 2.48893
CHD1 chromodomain helicase DNA binding protein 1 2.22445
SAV1 salvador family WW domain containing protein 1 2.09734
COBL cordon-bleu WH2 repeat protein 2.02983
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 2.02921
ZW10 zw10 kinetochore protein 2.00707
METRN meteorin, glial cell differentiation regulator 2.00688
LSG1 large 60S subunit nuclear export GTPase 1 2.00395

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.94194
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.72937
TXNDC9 thioredoxin domain containing 9 -3.51299
TEC tec protein tyrosine kinase -2.80351
ATG3 autophagy related 3 -2.7506
SSX5 synovial sarcoma, X breakpoint 5 -2.74608
BAG3 BCL2-associated athanogene 3 -2.71026
PCDHGA9 protocadherin gamma subfamily A, 9 -2.69943
ACKR2 atypical chemokine receptor 2 -2.53491
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.52223
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.5119
CHST10 carbohydrate sulfotransferase 10 -2.45315
VIM vimentin -2.42233
GPR173 G protein-coupled receptor 173 -2.35149
NPFFR1 neuropeptide FF receptor 1 -2.33789
DCAF4 DDB1 and CUL4 associated factor 4 -2.32766
CAB39 calcium binding protein 39 -2.32248
PRAMEF12 PRAME family member 12 -2.31881
KLHL35 kelch-like family member 35 -2.31513
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.31224
INSL6 insulin-like 6 -2.30201
DOK3 docking protein 3 -2.29058
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.2886
WNT1 wingless-type MMTV integration site family, member 1 -2.28761
PRDM16 PR domain containing 16 -2.2755
APIP APAF1 interacting protein -2.27193
RGSL1 regulator of G-protein signaling like 1 -2.26427
ADPRH ADP-ribosylarginine hydrolase -2.25544
SCIN scinderin -2.25272
PTH2R parathyroid hormone 2 receptor -2.2439
FOXE3 forkhead box E3 -2.24369
CCNP cyclin P -2.24042
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.23777
OVOL3 ovo-like zinc finger 3 -2.22609
ADORA2B adenosine A2b receptor -2.2201
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) -2.21758
LUZP4 leucine zipper protein 4 -2.20575
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.20567
LRRC3 leucine rich repeat containing 3 -2.18349
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.18222
GRTP1 growth hormone regulated TBC protein 1 -2.18088
HHIPL2 HHIP-like 2 -2.17979
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 -2.1699
ANGPT4 angiopoietin 4 -2.16901
AMELY amelogenin, Y-linked -2.16306
RLBP1 retinaldehyde binding protein 1 -2.16234
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 -2.16102
CDHR1 cadherin-related family member 1 -2.15951
TAC3 tachykinin 3 -2.15708
CATSPERG catsper channel auxiliary subunit gamma -2.15416
AIG1 androgen-induced 1 -2.15209
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.15126
ZXDC ZXD family zinc finger C -2.15089
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -2.14793
ACTN3 actinin, alpha 3 (gene/pseudogene) -2.14592
PAX7 paired box 7 -2.14554
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -2.13368
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.13346
OR5I1 olfactory receptor, family 5, subfamily I, member 1 -2.13198
LMAN2L lectin, mannose-binding 2-like -2.12697
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 -2.12666
PAX9 paired box 9 -2.12644
SLC66A3 solute carrier family 66 member 3 -2.12536
MC3R melanocortin 3 receptor -2.122
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.10902
CDK3 cyclin-dependent kinase 3 -2.10444
PRDM11 PR domain containing 11 -2.1033
KIF26B kinesin family member 26B -2.10163
FGF16 fibroblast growth factor 16 -2.10137
ALPK1 alpha-kinase 1 -2.10117
AMBN ameloblastin (enamel matrix protein) -2.09977
ATG10 autophagy related 10 -2.09205
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.09047
CRLF2 cytokine receptor-like factor 2 -2.09045
ATXN7L1 ataxin 7-like 1 -2.08602
IL36A interleukin 36, alpha -2.0785
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -2.07844
CRYBA1 crystallin, beta A1 -2.07779
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) -2.07248
DGKQ diacylglycerol kinase, theta 110kDa -2.07222
CRYBB3 crystallin, beta B3 -2.06937
ZBTB32 zinc finger and BTB domain containing 32 -2.0676
TTC22 tetratricopeptide repeat domain 22 -2.06658
LHX1 LIM homeobox 1 -2.06527
MTMR10 myotubularin related protein 10 -2.06119
PYGO1 pygopus family PHD finger 1 -2.05838
IL22RA1 interleukin 22 receptor, alpha 1 -2.05794
PRAMEF26 PRAME family member 26 -2.05759
SOAT2 sterol O-acyltransferase 2 -2.05631
GPR21 G protein-coupled receptor 21 -2.05615
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 -2.05482
FGF3 fibroblast growth factor 3 -2.05374
DRC4 dynein regulatory complex subunit 4 -2.05178
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.04937
PDE11A phosphodiesterase 11A -2.04912
ADAM20 ADAM metallopeptidase domain 20 -2.04681
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.04518
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.04319
ARR3 arrestin 3, retinal (X-arrestin) -2.04078
SHH sonic hedgehog -2.039
GAST gastrin -2.03195
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.03088
RGS10 regulator of G-protein signaling 10 -2.02843
AVPR1B arginine vasopressin receptor 1B -2.02811
COLEC10 collectin sub-family member 10 (C-type lectin) -2.02761
MSMO1 methylsterol monooxygenase 1 -2.02413
ALX4 ALX homeobox 4 -2.02388
NPY2R neuropeptide Y receptor Y2 -2.02301
GPR31 G protein-coupled receptor 31 -2.02129
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 -2.01908
BMP10 bone morphogenetic protein 10 -2.015
CDX1 caudal type homeobox 1 -2.0133
MRLN myoregulin -2.01175
PRDM5 PR domain containing 5 -2.00957
NLRP1 NLR family, pyrin domain containing 1 -2.00213
OR1D2 olfactory receptor, family 1, subfamily D, member 2 -2.00021