CRCGN015_MCF10A_48H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 100.09 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

202 genes differentially expressed following the CRCGN015_MCF10A_48H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.07988
ANO10 anoctamin 10 4.02323
FHL2 four and a half LIM domains 2 3.30624
SNX11 sorting nexin 11 3.29295
BZW2 basic leucine zipper and W2 domains 2 3.22184
NUCB2 nucleobindin 2 3.15637
GLRX glutaredoxin (thioltransferase) 2.9976
DYNLT3 dynein, light chain, Tctex-type 3 2.96622
GDI1 GDP dissociation inhibitor 1 2.95708
TXNRD1 thioredoxin reductase 1 2.88757
SQSTM1 sequestosome 1 2.74547
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.68978
MVP major vault protein 2.67575
DUSP4 dual specificity phosphatase 4 2.65295
SLC38A10 solute carrier family 38, member 10 2.65013
DUSP6 dual specificity phosphatase 6 2.55974
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.55558
IL4R interleukin 4 receptor 2.53196
SIL1 SIL1 nucleotide exchange factor 2.40295
CHPF2 chondroitin polymerizing factor 2 2.38942
NAGK N-acetylglucosamine kinase 2.35408
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.33688
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.25824
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.23512
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.2334
DUSP5 dual specificity phosphatase 5 2.20391
CDPF1 cysteine-rich, DPF motif domain containing 1 2.19038
CLTC clathrin, heavy chain (Hc) 2.17989
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 2.17638
MINDY3 MINDY lysine 48 deubiquitinase 3 2.16473
ATG4A autophagy related 4A, cysteine peptidase 2.16413
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.14214
MAGED2 melanoma antigen family D2 2.12566
NSF N-ethylmaleimide-sensitive factor 2.11128
RTL8C retrotransposon Gag like 8C 2.1065
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.10482
SLC67A1 solute carrier family 67 member 1 2.10385
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.08927
KXD1 KxDL motif containing 1 2.08571
LRP10 low density lipoprotein receptor-related protein 10 2.08432
IFI35 interferon-induced protein 35 2.08416
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.07602
SAMD9 sterile alpha motif domain containing 9 2.07541
APOL6 apolipoprotein L, 6 2.07386
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.07158
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.06074
CHGB chromogranin B 2.05677
IFI6 interferon, alpha-inducible protein 6 2.05507
TFF3 trefoil factor 3 (intestinal) 2.0493
NECTIN2 nectin cell adhesion molecule 2 2.04632
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2.04361
TSPAN13 tetraspanin 13 2.03858
PARP12 poly (ADP-ribose) polymerase family, member 12 2.02482
LYPD3 LY6/PLAUR domain containing 3 2.0231
NCSTN nicastrin 2.02113
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.01519
HSPB1 heat shock 27kDa protein 1 2.0067
STRADA STE20-related kinase adaptor alpha 2.00405

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -7.67163
CCNB2 cyclin B2 -4.72882
KIF14 kinesin family member 14 -4.23324
LDHB lactate dehydrogenase B -4.09089
CDC20 cell division cycle 20 -4.01734
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.83129
NEK2 NIMA-related kinase 2 -3.77965
TWNK twinkle mtDNA helicase -3.33605
HMGB2 high mobility group box 2 -3.3274
FOXM1 forkhead box M1 -3.29891
NDC1 NDC1 transmembrane nucleoporin -3.26778
SMNDC1 survival motor neuron domain containing 1 -3.24191
MELK maternal embryonic leucine zipper kinase -3.22556
CCNA2 cyclin A2 -3.21418
UBE2C ubiquitin-conjugating enzyme E2C -3.20459
SNX7 sorting nexin 7 -3.11418
PLK1 polo-like kinase 1 -3.06894
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.06152
KIF20A kinesin family member 20A -3.04223
BIRC5 baculoviral IAP repeat containing 5 -3.02514
CENPA centromere protein A -3.00982
LBR lamin B receptor -2.94871
GAR1 GAR1 ribonucleoprotein -2.89114
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.89007
HSPA1A heat shock 70kDa protein 1A -2.88754
TSC22D3 TSC22 domain family, member 3 -2.88567
CDC25B cell division cycle 25B -2.87071
OIP5 Opa interacting protein 5 -2.85819
GPSM2 G-protein signaling modulator 2 -2.82767
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.82524
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.82382
TOP2A topoisomerase (DNA) II alpha 170kDa -2.78962
MIS18A MIS18 kinetochore protein A -2.78346
TRIP13 thyroid hormone receptor interactor 13 -2.76686
RPA3 replication protein A3, 14kDa -2.76537
TTK TTK protein kinase -2.75377
RXYLT1 ribitol xylosyltransferase 1 -2.748
SNRPE small nuclear ribonucleoprotein polypeptide E -2.73788
PAK1IP1 PAK1 interacting protein 1 -2.73011
KIF11 kinesin family member 11 -2.72125
HADH hydroxyacyl-CoA dehydrogenase -2.72048
NCAPD3 non-SMC condensin II complex, subunit D3 -2.69871
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.68577
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.68389
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.68376
EXOSC8 exosome component 8 -2.66054
PCOLCE procollagen C-endopeptidase enhancer -2.65304
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.64442
RPIA ribose 5-phosphate isomerase A -2.64381
KIF4A kinesin family member 4A -2.62511
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.61669
CDK4 cyclin-dependent kinase 4 -2.60369
GPHN gephyrin -2.5742
DEPDC1 DEP domain containing 1 -2.57293
ZNF263 zinc finger protein 263 -2.54584
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.54349
EXOSC5 exosome component 5 -2.54007
PER1 period circadian clock 1 -2.53442
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.51054
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.50672
TCEAL4 transcription elongation factor A (SII)-like 4 -2.48559
FANCI Fanconi anemia, complementation group I -2.47509
RUVBL1 RuvB-like AAA ATPase 1 -2.47452
DBF4 DBF4 zinc finger -2.44739
CETN3 centrin, EF-hand protein, 3 -2.44643
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.44123
ZBTB16 zinc finger and BTB domain containing 16 -2.43378
KIF18A kinesin family member 18A -2.4304
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.42272
CDC25C cell division cycle 25C -2.42244
ZFAND1 zinc finger, AN1-type domain 1 -2.41067
RAI14 retinoic acid induced 14 -2.40601
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.39733
KIF15 kinesin family member 15 -2.39305
PIMREG PICALM interacting mitotic regulator -2.38902
RFC3 replication factor C (activator 1) 3, 38kDa -2.36916
TPX2 TPX2, microtubule-associated -2.36678
H2AZ1 H2A.Z variant histone 1 -2.35885
TACC3 transforming, acidic coiled-coil containing protein 3 -2.35475
SPC25 SPC25, NDC80 kinetochore complex component -2.34503
DZIP1 DAZ interacting zinc finger protein 1 -2.34369
PROSER1 proline and serine rich 1 -2.32833
EXO1 exonuclease 1 -2.31875
ALPL alkaline phosphatase, liver/bone/kidney -2.3181
PARPBP PARP1 binding protein -2.30409
TROAP trophinin associated protein -2.29722
CEP55 centrosomal protein 55kDa -2.29638
WDR77 WD repeat domain 77 -2.29449
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.27716
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.27468
RPP30 ribonuclease P/MRP 30kDa subunit -2.2721
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.2614
SNRPG small nuclear ribonucleoprotein polypeptide G -2.26111
SCML2 sex comb on midleg-like 2 (Drosophila) -2.25997
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.25686
CKS1B CDC28 protein kinase regulatory subunit 1B -2.25548
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -2.24209
OSBPL11 oxysterol binding protein-like 11 -2.24144
SPDL1 spindle apparatus coiled-coil protein 1 -2.23137
USP39 ubiquitin specific peptidase 39 -2.2279
CSRP2 cysteine and glycine-rich protein 2 -2.22606
DEK DEK proto-oncogene -2.2226
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.20931
NOP14 NOP14 nucleolar protein -2.2046
ADRB2 adrenoceptor beta 2, surface -2.20379
ECT2 epithelial cell transforming 2 -2.19614
ACOD1 aconitate decarboxylase 1 -2.18988
SINHCAF SIN3-HDAC complex associated factor -2.18574
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.18509
BBS10 Bardet-Biedl syndrome 10 -2.18361
CDCA3 cell division cycle associated 3 -2.18259
DDIT4 DNA-damage-inducible transcript 4 -2.17938
DCK deoxycytidine kinase -2.15177
FBL fibrillarin -2.14064
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13869
PSRC1 proline/serine-rich coiled-coil 1 -2.13602
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.13589
PRC1 protein regulator of cytokinesis 1 -2.13041
TTC27 tetratricopeptide repeat domain 27 -2.12977
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.12382
CUTC cutC copper transporter -2.11062
PYDC1 PYD (pyrin domain) containing 1 -2.11011
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.10645
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.10318
ATAD2 ATPase family, AAA domain containing 2 -2.1008
ANXA3 annexin A3 -2.08968
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.08959
EBNA1BP2 EBNA1 binding protein 2 -2.07794
IPO4 importin 4 -2.07781
INTS13 integrator complex subunit 13 -2.06153
CDCA8 cell division cycle associated 8 -2.05838
HMGB1 high mobility group box 1 -2.04666
SNRPA small nuclear ribonucleoprotein polypeptide A -2.04037
SRSF3 serine/arginine-rich splicing factor 3 -2.0226
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.02093
PNRC2 proline-rich nuclear receptor coactivator 2 -2.02078
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.01841
FKBP5 FK506 binding protein 5 -2.01816
RBM22 RNA binding motif protein 22 -2.01524
TMEM243 transmembrane protein 243, mitochondrial -2.01175
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.0036
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.0024
LMNB1 lamin B1 -2.00142
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.00135