CRCGN015_MCF10A_48H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 11.39 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

256 genes differentially expressed following the CRCGN015_MCF10A_48H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.99035
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.11575
WIF1 WNT inhibitory factor 1 5.0
TBC1D10C TBC1 domain family, member 10C 4.5393
ZBTB32 zinc finger and BTB domain containing 32 4.20075
CXCR4 chemokine (C-X-C motif) receptor 4 3.91272
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.2274
B3GAT3 beta-1,3-glucuronyltransferase 3 3.2212
METTL25B methyltransferase like 25B 3.0972
ARF5 ADP-ribosylation factor 5 3.01135
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.9905
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.94885
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.92915
YIPF2 Yip1 domain family, member 2 2.9275
FXR2 fragile X mental retardation, autosomal homolog 2 2.89405
SCT secretin 2.8625
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.84775
MVD mevalonate (diphospho) decarboxylase 2.83875
HMGXB4 HMG box domain containing 4 2.8084
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.8068
USP18 ubiquitin specific peptidase 18 2.73395
ARFIP1 ADP-ribosylation factor interacting protein 1 2.7304
CADM4 cell adhesion molecule 4 2.7246
HOXB3 homeobox B3 2.7105
INTS3 integrator complex subunit 3 2.67715
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.67655
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.6704
NLRP2B NLR family pyrin domain containing 2B 2.6463
MED15 mediator complex subunit 15 2.6216
KDM1A lysine (K)-specific demethylase 1A 2.61965
MED24 mediator complex subunit 24 2.56915
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.5524
ZNF282 zinc finger protein 282 2.53735
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.53395
IL2RB interleukin 2 receptor, beta 2.53335
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.53265
TRIM25 tripartite motif containing 25 2.5226
NT5C 5', 3'-nucleotidase, cytosolic 2.52135
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.51785
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.5158
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.4908
TNRC6B trinucleotide repeat containing 6B 2.47935
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.47605
PYCR1 pyrroline-5-carboxylate reductase 1 2.47495
DUSP14 dual specificity phosphatase 14 2.4712
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.46495
CLCN3 chloride channel, voltage-sensitive 3 2.4642
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.46245
ASCC2 activating signal cointegrator 1 complex subunit 2 2.4493
KRI1 KRI1 homolog (S. cerevisiae) 2.4439
RFXAP regulatory factor X-associated protein 2.443
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.4343
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.4328
MYO18A myosin XVIIIA 2.42615
ZNF205 zinc finger protein 205 2.41545
ACBD4 acyl-CoA binding domain containing 4 2.41285
FBRS fibrosin 2.39945
GIPC1 GIPC PDZ domain containing family, member 1 2.39695
SDK2 sidekick cell adhesion molecule 2 2.3744
CXCL13 chemokine (C-X-C motif) ligand 13 2.3643
CGB8 chorionic gonadotropin, beta polypeptide 8 2.3599
AIM2 absent in melanoma 2 2.3592
DCTN3 dynactin 3 (p22) 2.35695
PCGF2 polycomb group ring finger 2 2.35561
SPOUT1 SPOUT domain containing methyltransferase 1 2.35495
TTC38 tetratricopeptide repeat domain 38 2.3477
CLSTN3 calsyntenin 3 2.34395
PSD4 pleckstrin and Sec7 domain containing 4 2.34165
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.32985
MSX1 msh homeobox 1 2.32775
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 2.32347
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.31397
KAT5 K(lysine) acetyltransferase 5 2.31378
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.30315
BCL7C B-cell CLL/lymphoma 7C 2.2917
FGF17 fibroblast growth factor 17 2.28
PMM1 phosphomannomutase 1 2.27525
AMN amnion associated transmembrane protein 2.27085
IBSP integrin-binding sialoprotein 2.266
FGGY FGGY carbohydrate kinase domain containing 2.26475
CRTAM cytotoxic and regulatory T cell molecule 2.2578
ZNF443 zinc finger protein 443 2.2543
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.25035
ENOSF1 enolase superfamily member 1 2.24114
ATAD3A ATPase family, AAA domain containing 3A 2.23885
YBX3 Y box binding protein 3 2.23532
C1QA complement component 1, q subcomponent, A chain 2.22985
TPPP tubulin polymerization promoting protein 2.22925
TBX19 T-box 19 2.2261
RCE1 Ras converting CAAX endopeptidase 1 2.2258
PTCD1 pentatricopeptide repeat domain 1 2.21585
BORCS6 BLOC-1 related complex subunit 6 2.20275
PDCD1 programmed cell death 1 2.19795
S100A14 S100 calcium binding protein A14 2.19605
CYTH3 cytohesin 3 2.19345
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.193
TRAPPC8 trafficking protein particle complex 8 2.19025
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.1891
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.1883
PDLIM1 PDZ and LIM domain 1 2.18665
DROSHA drosha, ribonuclease type III 2.1816
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.17762
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.17615
GALK1 galactokinase 1 2.1759
BBS1 Bardet-Biedl syndrome 1 2.1758
ELOA elongin A 2.17528
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.1712
NPM3 nucleophosmin/nucleoplasmin 3 2.16595
ODF2 outer dense fiber of sperm tails 2 2.16365
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.1619
RLF rearranged L-myc fusion 2.15985
ZNF646 zinc finger protein 646 2.1589
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.15335
PCTP phosphatidylcholine transfer protein 2.14675
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.1456
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.1452
FAHD2A fumarylacetoacetate hydrolase domain containing 2A 2.1422
PRPF18 pre-mRNA processing factor 18 2.14085
HPS4 Hermansky-Pudlak syndrome 4 2.13457
GPR18 G protein-coupled receptor 18 2.12015
KCTD7 potassium channel tetramerization domain containing 7 2.1175
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.10997
RAB17 RAB17, member RAS oncogene family 2.1078
CMTR1 cap methyltransferase 1 2.10615
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.10255
TIPRL TOR signaling pathway regulator 2.0986
THRAP3 thyroid hormone receptor associated protein 3 2.09545
CD247 CD247 molecule 2.0912
BIRC7 baculoviral IAP repeat containing 7 2.08785
ZNF212 zinc finger protein 212 2.08745
NOL11 nucleolar protein 11 2.08625
CLCA1 chloride channel accessory 1 2.0849
CALCOCO2 calcium binding and coiled-coil domain 2 2.0812
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.078
SOCS3 suppressor of cytokine signaling 3 2.07527
NUP205 nucleoporin 205kDa 2.0731
GCLC glutamate-cysteine ligase, catalytic subunit 2.0731
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 2.0726
TOM1L1 target of myb1 (chicken)-like 1 2.069
CLDN4 claudin 4 2.0673
DGCR6L DiGeorge syndrome critical region gene 6-like 2.0654
P3H3 prolyl 3-hydroxylase 3 2.06515
ECSIT ECSIT signalling integrator 2.0648
MPC2 mitochondrial pyruvate carrier 2 2.0585
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.0494
CCDC86 coiled-coil domain containing 86 2.0469
DDR1 discoidin domain receptor tyrosine kinase 1 2.04533
BRIX1 BRX1, biogenesis of ribosomes 2.04375
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.0408
THAP7 THAP domain containing 7 2.03855
RBM42 RNA binding motif protein 42 2.03705
SLC39A1 solute carrier family 39 (zinc transporter), member 1 2.03535
CHIA chitinase, acidic 2.0329
PHF11 PHD finger protein 11 2.0324
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.0315
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 2.0253
UBE4B ubiquitination factor E4B 2.01876
GRB2 growth factor receptor-bound protein 2 2.01665
LAG3 lymphocyte-activation gene 3 2.00995
PAX9 paired box 9 2.0051

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.1548
OXA1L oxidase (cytochrome c) assembly 1-like -4.94265
CYCS cytochrome c, somatic -4.40245
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.3196
HSPA1A heat shock 70kDa protein 1A -3.5705
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.44905
MT2A metallothionein 2A -3.2529
NLRP4 NLR family, pyrin domain containing 4 -3.2131
RPN1 ribophorin I -3.0668
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.9027
TMEM204 transmembrane protein 204 -2.8655
THBD thrombomodulin -2.84022
SMNDC1 survival motor neuron domain containing 1 -2.838
IMMT inner membrane protein, mitochondrial -2.8277
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.80575
TFCP2L1 transcription factor CP2-like 1 -2.78105
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.7689
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.75515
SGK1 serum/glucocorticoid regulated kinase 1 -2.7545
PCNP PEST proteolytic signal containing nuclear protein -2.7528
CTPS2 CTP synthase 2 -2.6743
CRYZ crystallin, zeta (quinone reductase) -2.66665
MTFR1 mitochondrial fission regulator 1 -2.6323
CKMT1A creatine kinase, mitochondrial 1A -2.6177
SARAF store-operated calcium entry-associated regulatory factor -2.5536
NGRN neugrin, neurite outgrowth associated -2.55025
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.53802
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.52472
CD24 CD24 molecule -2.52255
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.52205
FBXL6 F-box and leucine-rich repeat protein 6 -2.4881
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -2.4717
GFUS GDP-L-fucose synthase -2.4638
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.46065
AVEN apoptosis, caspase activation inhibitor -2.4373
NPDC1 neural proliferation, differentiation and control, 1 -2.43495
NANS N-acetylneuraminic acid synthase -2.42855
STXBP2 syntaxin binding protein 2 -2.4241
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.4184
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -2.40917
CFP complement factor properdin -2.40145
NPY1R neuropeptide Y receptor Y1 -2.39745
GPX7 glutathione peroxidase 7 -2.3952
CSRP2 cysteine and glycine-rich protein 2 -2.37298
IGFBP7 insulin-like growth factor binding protein 7 -2.35398
IER3 immediate early response 3 -2.33745
ESRRG estrogen-related receptor gamma -2.31015
AOX1 aldehyde oxidase 1 -2.30588
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -2.29545
ZNF611 zinc finger protein 611 -2.28295
TMX2 thioredoxin-related transmembrane protein 2 -2.27565
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.25058
ZYX zyxin -2.24875
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.23105
DYSF dysferlin -2.2289
ACAA1 acetyl-CoA acyltransferase 1 -2.2257
LYRM1 LYR motif containing 1 -2.22135
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.20885
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -2.20395
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.203
RAP1GAP2 RAP1 GTPase activating protein 2 -2.2024
ACVR1 activin A receptor, type I -2.1983
WASHC5 WASH complex subunit 5 -2.1898
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.18915
GMPS guanine monphosphate synthase -2.18135
PPARG peroxisome proliferator-activated receptor gamma -2.18035
BABAM2 BRISC and BRCA1 A complex member 2 -2.17658
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.16465
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.16425
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.1556
THBS4 thrombospondin 4 -2.15215
PPCS phosphopantothenoylcysteine synthetase -2.1426
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.1318
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.1281
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.12495
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.1139
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.10355
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.1021
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.0864
ACOT2 acyl-CoA thioesterase 2 -2.07745
PSENEN presenilin enhancer gamma secretase subunit -2.05795
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.0518
RNF4 ring finger protein 4 -2.04405
HAUS2 HAUS augmin-like complex, subunit 2 -2.0398
ADGRF5 adhesion G protein-coupled receptor F5 -2.03915
GLT8D2 glycosyltransferase 8 domain containing 2 -2.0385
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 -2.0375
JAK1 Janus kinase 1 -2.03125
TG thyroglobulin -2.02625
CRABP1 cellular retinoic acid binding protein 1 -2.02445
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.023
CCNL1 cyclin L1 -2.02185
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.0192
AGTPBP1 ATP/GTP binding protein 1 -2.0087
DDIT4 DNA-damage-inducible transcript 4 -2.0016
RAB5IF RAB5 interacting factor -2.0005