CRCGN015_MCF10A_48H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclohexylamine.hcl 101.47 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN015_MCF10A_48H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.77912
FPGS folylpolyglutamate synthase 3.73074
ZNF282 zinc finger protein 282 3.15379
CD151 CD151 molecule (Raph blood group) 3.11757
NANOS3 nanos homolog 3 (Drosophila) 2.85447
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.83339
LAG3 lymphocyte-activation gene 3 2.7153
INTS3 integrator complex subunit 3 2.68121
KCTD5 potassium channel tetramerization domain containing 5 2.65095
RHEB Ras homolog enriched in brain 2.61189
SIRT3 sirtuin 3 2.52002
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.50414
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.49409
MED24 mediator complex subunit 24 2.44626
NUP133 nucleoporin 133kDa 2.43271
MKS1 Meckel syndrome, type 1 2.41712
IL2RB interleukin 2 receptor, beta 2.40485
ADAM15 ADAM metallopeptidase domain 15 2.40146
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.38807
SLAMF1 signaling lymphocytic activation molecule family member 1 2.38228
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.37759
ARF5 ADP-ribosylation factor 5 2.36534
LRRC31 leucine rich repeat containing 31 2.34427
DUSP14 dual specificity phosphatase 14 2.33991
STX1A syntaxin 1A (brain) 2.33691
KCTD7 potassium channel tetramerization domain containing 7 2.32208
HRAS Harvey rat sarcoma viral oncogene homolog 2.31626
CH25H cholesterol 25-hydroxylase 2.31534
TMEM80 transmembrane protein 80 2.30231
SMTN smoothelin 2.30128
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.2812
CXCR3 chemokine (C-X-C motif) receptor 3 2.28056
MRC1 mannose receptor, C type 1 2.277
MOGAT1 monoacylglycerol O-acyltransferase 1 2.2405
SIRPG signal-regulatory protein gamma 2.23631
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 2.2338
USP18 ubiquitin specific peptidase 18 2.22882
FUZ fuzzy planar cell polarity protein 2.22684
CXCL13 chemokine (C-X-C motif) ligand 13 2.22406
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.21081
BRIX1 BRX1, biogenesis of ribosomes 2.19891
NPTN neuroplastin 2.19063
GET1 guided entry of tail-anchored proteins factor 1 2.18285
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.17804
ITPKC inositol-trisphosphate 3-kinase C 2.16192
CLSTN3 calsyntenin 3 2.15977
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.15062
TTC38 tetratricopeptide repeat domain 38 2.13202
LRRC59 leucine rich repeat containing 59 2.12526
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.11184
DCAF6 DDB1 and CUL4 associated factor 6 2.10411
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.10174
EXOC2 exocyst complex component 2 2.10161
ECI2 enoyl-CoA delta isomerase 2 2.09048
CAPNS1 calpain, small subunit 1 2.05895
CKAP5 cytoskeleton associated protein 5 2.05089
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.04384
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.03453
CAPRIN2 caprin family member 2 2.01738
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.01114
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.00949
EVC Ellis van Creveld protein 2.00378

decreased expression

Symbol Name Standardized Value
PRPF4 pre-mRNA processing factor 4 -5.80201
S100A8 S100 calcium binding protein A8 -4.39276
MT2A metallothionein 2A -4.06588
PCCB propionyl CoA carboxylase, beta polypeptide -3.46711
ANXA3 annexin A3 -3.35859
SLC31A1 solute carrier family 31 (copper transporter), member 1 -3.26549
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -3.20988
YME1L1 YME1-like 1 ATPase -3.18098
MT1X metallothionein 1X -3.12633
MSMO1 methylsterol monooxygenase 1 -3.11082
MACO1 macoilin 1 -2.94321
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.86426
RPN1 ribophorin I -2.76806
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.7522
CCNH cyclin H -2.65515
MXD1 MAX dimerization protein 1 -2.64676
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.64002
HSPA1A heat shock 70kDa protein 1A -2.60861
MCFD2 multiple coagulation factor deficiency 2 -2.56886
BSPRY B-box and SPRY domain containing -2.46587
PEX13 peroxisomal biogenesis factor 13 -2.45792
DUSP6 dual specificity phosphatase 6 -2.42885
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.35639
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -2.30939
PDZD8 PDZ domain containing 8 -2.2671
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.26521
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.24283
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.22926
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.22764
PF4 platelet factor 4 -2.19602
ALAD aminolevulinate dehydratase -2.18829
RNF139 ring finger protein 139 -2.17938
SMNDC1 survival motor neuron domain containing 1 -2.14257
MTFR1 mitochondrial fission regulator 1 -2.13742
AK8 adenylate kinase 8 -2.12608
NINJ1 ninjurin 1 -2.12153
KIFBP kinesin family binding protein -2.07019
GMPS guanine monphosphate synthase -2.05748
RAB21 RAB21, member RAS oncogene family -2.0495
CD24 CD24 molecule -2.0428
ADGRG6 adhesion G protein-coupled receptor G6 -2.03914
SURF2 surfeit 2 -2.00615