CRCGN015_MCF10A_48H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 101.47 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

175 genes differentially expressed following the CRCGN015_MCF10A_48H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AXIN1 axin 1 10.0
BAMBI BMP and activin membrane-bound inhibitor 5.6149
TLK2 tousled-like kinase 2 3.7955
FBXO11 F-box protein 11 3.07067
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 3.0395
COG7 component of oligomeric golgi complex 7 2.9639
HESX1 HESX homeobox 1 2.9368
ASB8 ankyrin repeat and SOCS box containing 8 2.8027
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.796
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.7653
PHACTR4 phosphatase and actin regulator 4 2.7527
ELAC2 elaC ribonuclease Z 2 2.6387
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.6223
GPC4 glypican 4 2.61885
ZNF629 zinc finger protein 629 2.6185
LUZP4 leucine zipper protein 4 2.6179
DPP8 dipeptidyl-peptidase 8 2.6056
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.60185
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.5979
STAC SH3 and cysteine rich domain 2.5949
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.564
GCC1 GRIP and coiled-coil domain containing 1 2.5599
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.5389
CA14 carbonic anhydrase XIV 2.5252
LARP1 La ribonucleoprotein domain family, member 1 2.50047
CNTLN centlein, centrosomal protein 2.4796
NANOG Nanog homeobox 2.4756
CHST10 carbohydrate sulfotransferase 10 2.4672
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 2.4664
TNPO3 transportin 3 2.41927
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.4188
ZNF384 zinc finger protein 384 2.3903
OR7C2 olfactory receptor, family 7, subfamily C, member 2 2.3898
MEPE matrix extracellular phosphoglycoprotein 2.3876
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.367
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.3507
GPR52 G protein-coupled receptor 52 2.3424
CNOT4 CCR4-NOT transcription complex, subunit 4 2.33636
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.3298
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.3287
RNF2 ring finger protein 2 2.3219
MBIP MAP3K12 binding inhibitory protein 1 2.3138
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 2.2876
GRIP2 glutamate receptor interacting protein 2 2.2811
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.2777
NCAPD2 non-SMC condensin I complex, subunit D2 2.2637
SV2B synaptic vesicle glycoprotein 2B 2.2595
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.258
HEATR6 HEAT repeat containing 6 2.25285
ZNF574 zinc finger protein 574 2.2509
CA12 carbonic anhydrase XII 2.24873
ZIC3 Zic family member 3 2.2421
ELOVL2 ELOVL fatty acid elongase 2 2.2387
DCLRE1B DNA cross-link repair 1B 2.2209
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.2193
ADPRH ADP-ribosylarginine hydrolase 2.2165
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 2.2154
DPF3 D4, zinc and double PHD fingers, family 3 2.2149
ZNF669 zinc finger protein 669 2.2138
COL21A1 collagen, type XXI, alpha 1 2.2109
ZNF208 zinc finger protein 208 2.2062
MED24 mediator complex subunit 24 2.2044
RSF1 remodeling and spacing factor 1 2.1944
GDF11 growth differentiation factor 11 2.19205
SPTBN4 spectrin, beta, non-erythrocytic 4 2.1885
AUNIP aurora kinase A and ninein interacting protein 2.1876
ATAD5 ATPase family, AAA domain containing 5 2.1872
SLC38A12 solute carrier family 38 member 12 2.1816
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.1774
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.177
RBM15B RNA binding motif protein 15B 2.1694
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.1505
TBC1D16 TBC1 domain family, member 16 2.1479
CT55 cancer/testis antigen 55 2.146
CCDC88A coiled-coil domain containing 88A 2.14535
TEX11 testis expressed 11 2.14
RNF187 ring finger protein 187 2.1392
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.1361
AHCTF1 AT hook containing transcription factor 1 2.1337
PADI1 peptidyl arginine deiminase, type I 2.1303
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 2.1291
ZNF324 zinc finger protein 324 2.1271
CXCL12 chemokine (C-X-C motif) ligand 12 2.12705
CLEC1A C-type lectin domain family 1, member A 2.1201
DRD5 dopamine receptor D5 2.1125
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 2.1073
SDC3 syndecan 3 2.1063
SPDEF SAM pointed domain containing ETS transcription factor 2.09963
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.0924
ZFP36 ZFP36 ring finger protein 2.0886
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 2.07258
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.0708
CCDC30 coiled-coil domain containing 30 2.0653
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.0639
CPAP centrosome assembly and centriole elongation protein 2.06
DNAH3 dynein, axonemal, heavy chain 3 2.0544
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.0535
HGH1 HGH1 homolog (S. cerevisiae) 2.05325
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.0502
PHC1 polyhomeotic homolog 1 (Drosophila) 2.0412
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.0409
ZNF35 zinc finger protein 35 2.0399
PGAP6 post-GPI attachment to proteins 6 2.0336
KIF5A kinesin family member 5A 2.033
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.0309
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.0213
AHCYL2 adenosylhomocysteinase-like 2 2.02115
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 2.0175
KPNA6 karyopherin alpha 6 (importin alpha 7) 2.01723
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.016
CRYM crystallin, mu 2.0153
TMEM209 transmembrane protein 209 2.0137
SSBP3 single stranded DNA binding protein 3 2.0103
PRUNE2 prune homolog 2 (Drosophila) 2.00275
KRT38 keratin 38, type I 2.0022
UBE2O ubiquitin-conjugating enzyme E2O 2.0017
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.0013

decreased expression

Symbol Name Standardized Value
CHIC2 cysteine-rich hydrophobic domain 2 -10.0
KRT7 keratin 7, type II -8.274
ANXA3 annexin A3 -8.2352
FBXO21 F-box protein 21 -6.89303
MBNL2 muscleblind-like splicing regulator 2 -5.4124
STAT1 signal transducer and activator of transcription 1, 91kDa -4.96097
VIM vimentin -4.0523
NLRP4 NLR family, pyrin domain containing 4 -3.7297
RPL39L ribosomal protein L39-like -3.1452
IRF9 interferon regulatory factor 9 -3.0894
GSTA4 glutathione S-transferase alpha 4 -2.806
KRT18 keratin 18, type I -2.7192
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.7014
AOX1 aldehyde oxidase 1 -2.69895
WASHC3 WASH complex subunit 3 -2.6061
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.5772
ZNF706 zinc finger protein 706 -2.5362
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.5361
UFSP2 UFM1-specific peptidase 2 -2.4398
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.4126
NAGK N-acetylglucosamine kinase -2.409
SORBS3 sorbin and SH3 domain containing 3 -2.40825
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.3683
PHF11 PHD finger protein 11 -2.3638
PHF10 PHD finger protein 10 -2.3562
PDLIM1 PDZ and LIM domain 1 -2.3506
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.3414
TXNDC15 thioredoxin domain containing 15 -2.3363
PRNP prion protein -2.3193
TOP6BL TOP6B like initiator of meiotic double strand breaks -2.2873
MAEA macrophage erythroblast attacher -2.2679
TM4SF1 transmembrane 4 L six family member 1 -2.25793
AOPEP aminopeptidase O (putative) -2.2561
MX1 MX dynamin-like GTPase 1 -2.2522
EFNA1 ephrin-A1 -2.2324
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 -2.194
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.1896
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.186
DCN decorin -2.1801
GATA6 GATA binding protein 6 -2.1716
TSG101 tumor susceptibility 101 -2.1545
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -2.14803
ADGRG2 adhesion G protein-coupled receptor G2 -2.1415
FIP1L1 factor interacting with PAPOLA and CPSF1 -2.1217
NSFL1C NSFL1 (p97) cofactor (p47) -2.11883
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.1102
AKAP11 A kinase (PRKA) anchor protein 11 -2.1032
XAF1 XIAP associated factor 1 -2.089
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -2.08407
ANXA5 annexin A5 -2.0604
EXOC1 exocyst complex component 1 -2.0562
CLDND1 claudin domain containing 1 -2.0532
ATG2B autophagy related 2B -2.0428
IFT88 intraflagellar transport 88 -2.0414
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.0373
EIF6 eukaryotic translation initiation factor 6 -2.0309
NELFA negative elongation factor complex member A -2.0286
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.0021