CRCGN015_MCF10A_48H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 33.99 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN015_MCF10A_48H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 4.04748
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.45387
SPAG4 sperm associated antigen 4 3.14134
WIF1 WNT inhibitory factor 1 3.11665
MAMLD1 mastermind-like domain containing 1 3.04622
TUBB6 tubulin, beta 6 class V 2.77723
TXNRD1 thioredoxin reductase 1 2.6692
CCNA1 cyclin A1 2.57104
TK1 thymidine kinase 1, soluble 2.54214
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.21568
EPYC epiphycan 2.13395
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.08021
DMAP1 DNA methyltransferase 1 associated protein 1 2.07568
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.07368
EPHB2 EPH receptor B2 2.06468
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.05325

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.14363
TNIP1 TNFAIP3 interacting protein 1 -3.43
HSPA1A heat shock 70kDa protein 1A -3.04548
S100A8 S100 calcium binding protein A8 -2.98218
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.96985
ATP11B ATPase, class VI, type 11B -2.87874
FBXW4 F-box and WD repeat domain containing 4 -2.61697
HEBP1 heme binding protein 1 -2.61303
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.60701
TM9SF3 transmembrane 9 superfamily member 3 -2.56992
SLC35F2 solute carrier family 35, member F2 -2.55113
SEC24B SEC24 family member B -2.36516
MVP major vault protein -2.34384
H2AC25 H2A clustered histone 25 -2.30155
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.20043
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.14218
TRIOBP TRIO and F-actin binding protein -2.00739
FOXO4 forkhead box O4 -2.00714