CRCGN015_MCF10A_48H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeic-acid 10.94 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

143 genes differentially expressed following the CRCGN015_MCF10A_48H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IGHMBP2 immunoglobulin mu binding protein 2 4.38843
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.70589
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.44468
SCRN1 secernin 1 3.42896
CEP192 centrosomal protein 192kDa 2.90949
NEMF nuclear export mediator factor 2.79562
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.78093
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.70225
HBA1 hemoglobin, alpha 1 2.69235
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 2.68388
TCEAL9 transcription elongation factor A like 9 2.60606
ZNHIT6 zinc finger, HIT-type containing 6 2.59019
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.52086
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.45977
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.45787
CENPU centromere protein U 2.44095
ZMYM1 zinc finger, MYM-type 1 2.38918
GEMIN6 gem (nuclear organelle) associated protein 6 2.38257
MMUT methylmalonyl-CoA mutase 2.37897
ODR4 odr-4 GPCR localization factor homolog 2.37352
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.36109
FPGS folylpolyglutamate synthase 2.35625
ZW10 zw10 kinetochore protein 2.3277
TZMP1 transition zone microprotein 1 2.29972
EMILIN1 elastin microfibril interfacer 1 2.2931
CHMP5 charged multivesicular body protein 5 2.28824
NGFR nerve growth factor receptor 2.27258
SYNPO2 synaptopodin 2 2.26499
SSBP2 single-stranded DNA binding protein 2 2.26482
PDGFRL platelet-derived growth factor receptor-like 2.24651
HAUS3 HAUS augmin-like complex, subunit 3 2.23126
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.22966
BRIX1 BRX1, biogenesis of ribosomes 2.22671
ZNF562 zinc finger protein 562 2.2242
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.2077
SCFD1 sec1 family domain containing 1 2.1904
ERGIC2 ERGIC and golgi 2 2.18967
CTBS chitobiase, di-N-acetyl- 2.18845
GJC2 gap junction protein, gamma 2, 47kDa 2.18582
ICAM2 intercellular adhesion molecule 2 2.17877
CASP8AP2 caspase 8 associated protein 2 2.17387
FKBP6 FK506 binding protein 6, 36kDa 2.16865
ELF2 E74-like factor 2 (ets domain transcription factor) 2.1543
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.14494
CCNJL cyclin J-like 2.14396
PRPF3 pre-mRNA processing factor 3 2.13163
TRAPPC4 trafficking protein particle complex 4 2.11733
MN1 meningioma (disrupted in balanced translocation) 1 2.11112
MRPL19 mitochondrial ribosomal protein L19 2.09851
NKAPD1 NKAP domain containing 1 2.09467
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.09155
GOLGA4 golgin A4 2.08534
KRABD4 KRAB domain containing 4 2.07823
CDC45 cell division cycle 45 2.07705
CBR4 carbonyl reductase 4 2.07453
TP53RK TP53 regulating kinase 2.07372
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.06782
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.06436
ZNF274 zinc finger protein 274 2.05101
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.04971
ZNF135 zinc finger protein 135 2.04339
PRR3 proline rich 3 2.03962
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.02928
CD320 CD320 molecule 2.02033
COL11A2 collagen, type XI, alpha 2 2.00266
NUP43 nucleoporin 43kDa 2.00045

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.0689
CDPF1 cysteine-rich, DPF motif domain containing 1 -4.59206
RALB v-ral simian leukemia viral oncogene homolog B -4.38272
FASTKD5 FAST kinase domains 5 -4.27868
KRT7 keratin 7, type II -4.12809
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.48021
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.44512
EVL Enah/Vasp-like -3.32806
KRT14 keratin 14, type I -3.17346
PGAM4 phosphoglycerate mutase family member 4 -3.1665
PUF60 poly-U binding splicing factor 60KDa -3.11881
PRKCD protein kinase C, delta -3.05091
IQGAP1 IQ motif containing GTPase activating protein 1 -3.05044
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.85707
TNIP1 TNFAIP3 interacting protein 1 -2.81915
GFUS GDP-L-fucose synthase -2.8072
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.78761
ACSF2 acyl-CoA synthetase family member 2 -2.76103
MVP major vault protein -2.72407
GIPC1 GIPC PDZ domain containing family, member 1 -2.70986
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.64224
OXA1L oxidase (cytochrome c) assembly 1-like -2.61538
CGGBP1 CGG triplet repeat binding protein 1 -2.54841
LASP1 LIM and SH3 protein 1 -2.51077
RBBP9 retinoblastoma binding protein 9 -2.50327
ANKFY1 ankyrin repeat and FYVE domain containing 1 -2.48391
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.40482
ELL2 elongation factor, RNA polymerase II, 2 -2.40313
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.35664
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.35199
ILK integrin-linked kinase -2.35028
TP53BP2 tumor protein p53 binding protein 2 -2.3494
HSPB1 heat shock 27kDa protein 1 -2.33916
DCBLD2 discoidin, CUB and LCCL domain containing 2 -2.30776
LOC124907782 dual specificity protein phosphatase 22 -2.30176
EXOC5 exocyst complex component 5 -2.29959
VAT1 vesicle amine transport 1 -2.26908
CDK6 cyclin-dependent kinase 6 -2.24308
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.20913
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.20739
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.20589
CCDC6 coiled-coil domain containing 6 -2.19214
S100A10 S100 calcium binding protein A10 -2.18937
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.18706
IFRD2 interferon-related developmental regulator 2 -2.17888
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.17822
TMOD3 tropomodulin 3 (ubiquitous) -2.17627
CXCL8 chemokine (C-X-C motif) ligand 8 -2.16368
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.15541
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.15479
XPO7 exportin 7 -2.14744
AEN apoptosis enhancing nuclease -2.14307
MTARC2 mitochondrial amidoxime reducing component 2 -2.13986
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.10921
PAQR6 progestin and adipoQ receptor family member VI -2.10885
GRB14 growth factor receptor-bound protein 14 -2.1077
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.10653
ARF1 ADP-ribosylation factor 1 -2.09974
SPRING1 SREBF pathway regulator in golgi 1 -2.0884
CDK4 cyclin-dependent kinase 4 -2.087
RBM42 RNA binding motif protein 42 -2.07958
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.06699
PLK2 polo-like kinase 2 -2.06537
ANO10 anoctamin 10 -2.06479
VIM vimentin -2.04852
YY1 YY1 transcription factor -2.04549
MAN2B1 mannosidase, alpha, class 2B, member 1 -2.03917
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.03555
CDYL chromodomain protein, Y-like -2.0348
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.03358
TGFBR1 transforming growth factor, beta receptor 1 -2.03209
ATP5F1A ATP synthase F1 subunit alpha -2.02508
NPDC1 neural proliferation, differentiation and control, 1 -2.0226
TFG TRK-fused gene -2.01663
MTMR12 myotubularin related protein 12 -2.0134
PRB2 proline-rich protein BstNI subfamily 2 -2.00828
CTSD cathepsin D -2.00802