CRCGN015_MCF10A_48H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 11.2 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

176 genes differentially expressed following the CRCGN015_MCF10A_48H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.93305
DLK1 delta-like 1 homolog (Drosophila) 5.0
ANO10 anoctamin 10 3.95795
CCNL2 cyclin L2 2.91555
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.8545
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.81485
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.80895
GMPR2 guanosine monophosphate reductase 2 2.79275
TFRC transferrin receptor 2.78
CERK ceramide kinase 2.7323
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.7214
TIMP2 TIMP metallopeptidase inhibitor 2 2.7074
MYG1 MYG1 exonuclease 2.6761
CD19 CD19 molecule 2.6668
VMP1 vacuole membrane protein 1 2.6354
FZD2 frizzled class receptor 2 2.63335
C5 complement component 5 2.62005
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.61985
ADAMDEC1 ADAM-like, decysin 1 2.61145
MOSPD1 motile sperm domain containing 1 2.595
PEG10 paternally expressed 10 2.59165
TNS3 tensin 3 2.59005
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.58065
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.54102
RIN2 Ras and Rab interactor 2 2.53405
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.51955
APOC3 apolipoprotein C-III 2.5187
FBXO21 F-box protein 21 2.49368
MMP2 matrix metallopeptidase 2 2.4809
EIF3D eukaryotic translation initiation factor 3, subunit D 2.47955
SGCE sarcoglycan, epsilon 2.47565
LRRC8D leucine rich repeat containing 8 family, member D 2.4612
LOC102724560 cystathionine beta-synthase 2.4564
CHIT1 chitinase 1 (chitotriosidase) 2.4487
ANPEP alanyl (membrane) aminopeptidase 2.43415
SAP25 Sin3A-associated protein, 25kDa 2.42002
GSTM2 glutathione S-transferase mu 2 (muscle) 2.4188
APOH apolipoprotein H (beta-2-glycoprotein I) 2.41045
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.38325
FFAR1 free fatty acid receptor 1 2.38255
TAC3 tachykinin 3 2.37385
MTA1 metastasis associated 1 2.36125
RTL8A retrotransposon Gag like 8A 2.357
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.3509
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 2.3447
CDK3 cyclin-dependent kinase 3 2.32945
APOA1 apolipoprotein A-I 2.326
IGF2 insulin-like growth factor 2 2.32522
APOB apolipoprotein B 2.31575
S100G S100 calcium binding protein G 2.30855
TCL1B T-cell leukemia/lymphoma 1B 2.29825
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.26525
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.262
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.26085
CLEC7A C-type lectin domain family 7, member A 2.24925
LUM lumican 2.2479
FGFR2 fibroblast growth factor receptor 2 2.24681
NFE2 nuclear factor, erythroid 2 2.22955
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.2291
ADGRE3 adhesion G protein-coupled receptor E3 2.2285
MARS1 methionyl-tRNA synthetase 1 2.22032
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.2135
GDAP1 ganglioside induced differentiation associated protein 1 2.2028
DEFA6 defensin, alpha 6, Paneth cell-specific 2.1984
PIBF1 progesterone immunomodulatory binding factor 1 2.1876
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.1773
APLP1 amyloid beta (A4) precursor-like protein 1 2.1758
SCAP SREBF chaperone 2.175
SNAP25 synaptosomal-associated protein, 25kDa 2.17205
C4BPA complement component 4 binding protein, alpha 2.16835
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 2.16
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.15515
SNCB synuclein, beta 2.14155
LMO4 LIM domain only 4 2.14097
TMCC2 transmembrane and coiled-coil domain family 2 2.10895
GATA4 GATA binding protein 4 2.1071
RAD21 RAD21 homolog (S. pombe) 2.1064
EXOSC5 exosome component 5 2.1037
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.10275
MYO15A myosin XVA 2.0997
FOXL2 forkhead box L2 2.09745
KEL Kell blood group, metallo-endopeptidase 2.09355
COL4A5 collagen, type IV, alpha 5 2.0902
KIF18B kinesin family member 18B 2.08525
DCT dopachrome tautomerase 2.0822
EXT1 exostosin glycosyltransferase 1 2.07035
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.0692
PIH1D1 PIH1 domain containing 1 2.0672
ADGRA2 adhesion G protein-coupled receptor A2 2.05985
GTF2B general transcription factor IIB 2.0576
TRIB3 tribbles pseudokinase 3 2.05565
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.0528
AHSP alpha hemoglobin stabilizing protein 2.05275
CPB2 carboxypeptidase B2 (plasma) 2.052
AARS1 alanyl-tRNA synthetase 1 2.0501
TMSB15C thymosin beta 15C 2.04905
SOCS1 suppressor of cytokine signaling 1 2.0454
CNTNAP1 contactin associated protein 1 2.04465
MNDA myeloid cell nuclear differentiation antigen 2.0431
COL13A1 collagen, type XIII, alpha 1 2.04137
WWC3 WWC family member 3 2.0407
SNX11 sorting nexin 11 2.03798
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.03505
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.0335
COL1A2 collagen, type I, alpha 2 2.02408
NSG2 neuronal vesicle trafficking associated 2 2.02335
MGAM maltase-glucoamylase 2.02065
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.0196
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.0128
DEFA5 defensin, alpha 5, Paneth cell-specific 2.01215
SPINK1 serine peptidase inhibitor, Kazal type 1 2.0061
ACP5 acid phosphatase 5, tartrate resistant 2.00525
GPR20 G protein-coupled receptor 20 2.00525
TMEM100 transmembrane protein 100 2.00495
FNBP1L formin binding protein 1-like 2.00055

decreased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A -5.3822
PGAM4 phosphoglycerate mutase family member 4 -5.28835
LAP3 leucine aminopeptidase 3 -5.23095
KRT14 keratin 14, type I -4.47965
MELK maternal embryonic leucine zipper kinase -3.41715
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.4094
GRPEL1 GrpE-like 1, mitochondrial (E. coli) -2.90158
TM9SF3 transmembrane 9 superfamily member 3 -2.7217
KLHDC4 kelch domain containing 4 -2.71385
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.68272
PDLIM1 PDZ and LIM domain 1 -2.65735
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.6435
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.60795
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -2.55638
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.5396
TOR1A torsin family 1, member A (torsin A) -2.49868
TDRD7 tudor domain containing 7 -2.4941
SRSF9 serine/arginine-rich splicing factor 9 -2.46158
TCTN3 tectonic family member 3 -2.44698
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.44415
GLOD4 glyoxalase domain containing 4 -2.43125
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.4151
HSPE1 heat shock 10kDa protein 1 -2.3978
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.3707
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.32857
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.3044
FAM222B family with sequence similarity 222, member B -2.2821
NENF neudesin neurotrophic factor -2.2718
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.2661
CUEDC2 CUE domain containing 2 -2.26585
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.2421
PMPCA peptidase (mitochondrial processing) alpha -2.2322
PFKP phosphofructokinase, platelet -2.20315
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.19735
HCFC2 host cell factor C2 -2.1964
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.1931
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -2.1895
TSPYL4 TSPY-like 4 -2.1892
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.17825
TSLIG3A tRNA splicing ligase complex subunit 3A -2.1782
CDC123 cell division cycle 123 -2.17525
SATB2 SATB homeobox 2 -2.1531
QDPR quinoid dihydropteridine reductase -2.14145
GRWD1 glutamate-rich WD repeat containing 1 -2.1295
TMEM9B TMEM9 domain family, member B -2.11495
CCN2 cellular communication network factor 2 -2.11
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.10425
IFRD2 interferon-related developmental regulator 2 -2.0984
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.09505
SPAG1 sperm associated antigen 1 -2.0904
CTSW cathepsin W -2.0855
TBC1D19 TBC1 domain family, member 19 -2.0735
IFI44L interferon-induced protein 44-like -2.03635
RPP30 ribonuclease P/MRP 30kDa subunit -2.03165
BLVRA biliverdin reductase A -2.02657
KDSR 3-ketodihydrosphingosine reductase -2.02345
PHF11 PHD finger protein 11 -2.01825
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.0175
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.01745
TSPAN1 tetraspanin 1 -2.0161
SEC61B Sec61 beta subunit -2.01225