CRCGN015_MCF10A_48H:G02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nifedipine 33.66 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

229 genes differentially expressed following the CRCGN015_MCF10A_48H:G02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 10.0
ZNF586 zinc finger protein 586 4.4993
ASNS asparagine synthetase (glutamine-hydrolyzing) 4.0519
PRKCD protein kinase C, delta 3.9903
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.78495
MSRA methionine sulfoxide reductase A 3.6854
IGHMBP2 immunoglobulin mu binding protein 2 3.23717
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 3.22285
PSAT1 phosphoserine aminotransferase 1 3.1731
ZFAND1 zinc finger, AN1-type domain 1 3.158
CIRBP cold inducible RNA binding protein 3.1125
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.0037
PDLIM1 PDZ and LIM domain 1 2.8462
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.84505
ACO1 aconitase 1, soluble 2.83865
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.8264
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.8189
PHGDH phosphoglycerate dehydrogenase 2.80075
EIF2D eukaryotic translation initiation factor 2D 2.77335
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 2.76095
MUTYH mutY homolog 2.7302
CDPF1 cysteine-rich, DPF motif domain containing 1 2.702
IL2RA interleukin 2 receptor, alpha 2.70005
MTM1 myotubularin 1 2.67357
MTMR11 myotubularin related protein 11 2.66685
COL13A1 collagen, type XIII, alpha 1 2.66527
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.66315
ADA2 adenosine deaminase 2 2.6615
CD83 CD83 molecule 2.6288
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.5775
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.57345
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.5698
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.54675
HAX1 HCLS1 associated protein X-1 2.5248
MARS1 methionyl-tRNA synthetase 1 2.52348
CSAD cysteine sulfinic acid decarboxylase 2.50375
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.50367
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.50093
G0S2 G0/G1 switch 2 2.46085
KLHL12 kelch-like family member 12 2.4369
KCTD14 potassium channel tetramerization domain containing 14 2.41975
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.4178
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.41302
GALT galactose-1-phosphate uridylyltransferase 2.40445
ATF4 activating transcription factor 4 2.391
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.37855
RBM4B RNA binding motif protein 4B 2.3728
RNF139 ring finger protein 139 2.36875
CCS copper chaperone for superoxide dismutase 2.368
PBLD phenazine biosynthesis-like protein domain containing 2.36135
PAIP2B poly(A) binding protein interacting protein 2B 2.35565
TYW2 tRNA wybutosine-synthesizing protein 2 2.35515
IL6 interleukin 6 2.33205
ZNF75D zinc finger protein 75D 2.32638
STX11 syntaxin 11 2.31475
FZD1 frizzled class receptor 1 2.30597
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.30585
WARS1 tryptophanyl-tRNA synthetase 1 2.3046
OCA2 oculocutaneous albinism II 2.28975
TMEM254 transmembrane protein 254 2.2847
DOK5 docking protein 5 2.2757
RFPL2 ret finger protein-like 2 2.26255
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.26175
RNF170 ring finger protein 170 2.25055
PARP3 poly (ADP-ribose) polymerase family, member 3 2.24895
ATG101 autophagy related 101 2.24745
CTNND2 catenin (cadherin-associated protein), delta 2 2.24575
ZNF532 zinc finger protein 532 2.2401
CCDC86 coiled-coil domain containing 86 2.23935
MID2 midline 2 2.23413
CD177 CD177 molecule 2.22935
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.22728
RPL10A ribosomal protein L10a 2.22265
SARS1 seryl-tRNA synthetase 1 2.22225
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.22145
PPIF peptidylprolyl isomerase F 2.2176
RFPL3 ret finger protein-like 3 2.21725
GAS6 growth arrest-specific 6 2.21685
ARMC1 armadillo repeat containing 1 2.20735
IL10RA interleukin 10 receptor, alpha 2.2025
GPM6B glycoprotein M6B 2.19747
FOXF2 forkhead box F2 2.19095
KRCC1 lysine-rich coiled-coil 1 2.18615
R3HDM2 R3H domain containing 2 2.1851
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.17575
OLFM4 olfactomedin 4 2.1586
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.14818
NGF nerve growth factor (beta polypeptide) 2.144
CAPRIN2 caprin family member 2 2.13925
HBEGF heparin-binding EGF-like growth factor 2.13335
BACE1 beta-site APP-cleaving enzyme 1 2.1317
C2CD5 C2 calcium-dependent domain containing 5 2.1249
ERLIN2 ER lipid raft associated 2 2.12435
PKP1 plakophilin 1 2.12343
FGF13 fibroblast growth factor 13 2.12265
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.11925
NEO1 neogenin 1 2.1183
LOC102724560 cystathionine beta-synthase 2.1148
HAT1 histone acetyltransferase 1 2.1072
S100A12 S100 calcium binding protein A12 2.0998
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.085
ZSCAN26 zinc finger and SCAN domain containing 26 2.0813
AOC1 amine oxidase, copper containing 1 2.08025
SYNGR1 synaptogyrin 1 2.07532
ADD2 adducin 2 (beta) 2.0753
WFDC1 WAP four-disulfide core domain 1 2.0711
HLA-DOB major histocompatibility complex, class II, DO beta 2.06925
SNAI2 snail family zinc finger 2 2.068
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 2.0652
TTC31 tetratricopeptide repeat domain 31 2.05495
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.0513
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.04838
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.03975
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.0368
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.02815
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.02803
PDZRN4 PDZ domain containing ring finger 4 2.01345
MAGED2 melanoma antigen family D2 2.0064
ENAH enabled homolog (Drosophila) 2.0053
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.0016

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.7918
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.09605
CD58 CD58 molecule -5.29908
RPA3 replication protein A3, 14kDa -5.06515
NUSAP1 nucleolar and spindle associated protein 1 -4.45305
CAB39 calcium binding protein 39 -4.2495
HEATR1 HEAT repeat containing 1 -4.15693
NAT10 N-acetyltransferase 10 (GCN5-related) -3.91435
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.4974
SYNJ2BP synaptojanin 2 binding protein -3.49565
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -3.42875
VIM vimentin -3.42505
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.36427
CDC20 cell division cycle 20 -3.32855
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.2688
INSIG1 insulin induced gene 1 -3.22337
BARD1 BRCA1 associated RING domain 1 -3.17115
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -3.16817
TOP2A topoisomerase (DNA) II alpha 170kDa -2.98898
CKS2 CDC28 protein kinase regulatory subunit 2 -2.90895
DAAM1 dishevelled associated activator of morphogenesis 1 -2.85185
CCNB2 cyclin B2 -2.8468
MCM6 minichromosome maintenance complex component 6 -2.8444
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.7768
GPSM2 G-protein signaling modulator 2 -2.75682
MGP matrix Gla protein -2.73325
CGB8 chorionic gonadotropin, beta polypeptide 8 -2.72925
TSPAN4 tetraspanin 4 -2.70975
MAP1S microtubule-associated protein 1S -2.69725
DMAC2L distal membrane arm assembly component 2 like -2.6678
TTK TTK protein kinase -2.633
KIF20A kinesin family member 20A -2.62015
LDHA lactate dehydrogenase A -2.6152
SNW1 SNW domain containing 1 -2.61445
GPHN gephyrin -2.61015
CDKN3 cyclin-dependent kinase inhibitor 3 -2.5914
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.565
KIAA0586 KIAA0586 -2.5511
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.54775
NECTIN2 nectin cell adhesion molecule 2 -2.5291
LIMS1 LIM and senescent cell antigen-like domains 1 -2.52312
AMACR alpha-methylacyl-CoA racemase -2.51933
PROCR protein C receptor, endothelial -2.4913
ZBTB16 zinc finger and BTB domain containing 16 -2.47905
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.4733
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.4704
PLK1 polo-like kinase 1 -2.4463
MCM9 minichromosome maintenance complex component 9 -2.42095
CKAP5 cytoskeleton associated protein 5 -2.40585
CCND3 cyclin D3 -2.35105
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) -2.34955
EIF3B eukaryotic translation initiation factor 3, subunit B -2.33608
KIF18A kinesin family member 18A -2.33265
RMI1 RecQ mediated genome instability 1 -2.28685
TPX2 TPX2, microtubule-associated -2.2726
ZNF226 zinc finger protein 226 -2.27035
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.25545
ERCC2 excision repair cross-complementation group 2 -2.2522
ADA adenosine deaminase -2.24055
TUBA3C tubulin, alpha 3c -2.24005
ERH enhancer of rudimentary homolog (Drosophila) -2.23785
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.2367
ERCC6L excision repair cross-complementation group 6-like -2.227
TTC1 tetratricopeptide repeat domain 1 -2.22315
ZNF143 zinc finger protein 143 -2.2204
KIF4A kinesin family member 4A -2.21835
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.2165
MACF1 microtubule-actin crosslinking factor 1 -2.2143
APIP APAF1 interacting protein -2.20905
FADS2 fatty acid desaturase 2 -2.20285
MARK4 MAP/microtubule affinity-regulating kinase 4 -2.19842
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -2.19605
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.1636
HJURP Holliday junction recognition protein -2.1606
SAP30L SAP30-like -2.1539
THBS4 thrombospondin 4 -2.1512
S100A3 S100 calcium binding protein A3 -2.1429
LZTFL1 leucine zipper transcription factor-like 1 -2.13905
NRN1 neuritin 1 -2.1361
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -2.12803
CDK1 cyclin-dependent kinase 1 -2.12483
ARMC7 armadillo repeat containing 7 -2.11275
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -2.11245
ADGRF5 adhesion G protein-coupled receptor F5 -2.09203
STMN1 stathmin 1 -2.0915
ZNF12 zinc finger protein 12 -2.0896
ENG endoglin -2.07995
PDPN podoplanin -2.06882
CCNA2 cyclin A2 -2.06728
TFB1M transcription factor B1, mitochondrial -2.0619
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.05745
CTNND1 catenin (cadherin-associated protein), delta 1 -2.0523
INTS15 integrator complex subunit 15 -2.04423
DEPDC1 DEP domain containing 1 -2.0428
ZNF410 zinc finger protein 410 -2.04192
RAP2A RAP2A, member of RAS oncogene family -2.0416
TEX10 testis expressed 10 -2.0411
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.03977
LMO2 LIM domain only 2 (rhombotin-like 1) -2.03255
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.0302
RRM2 ribonucleotide reductase M2 -2.02688
CDH5 cadherin 5, type 2 (vascular endothelium) -2.02515
MICALL2 MICAL-like 2 -2.0175
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.01685
MRPL17 mitochondrial ribosomal protein L17 -2.0144
ZNF83 zinc finger protein 83 -2.01385
ADIPOR2 adiponectin receptor 2 -2.013
HOXA7 homeobox A7 -2.00445
ASTE1 asteroid homolog 1 (Drosophila) -2.00045