CRCGN015_MCF10A_48H:G10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopyrrolidine 105.01 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

110 genes differentially expressed following the CRCGN015_MCF10A_48H:G10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein 5.31495
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.1759
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.05737
MAMLD1 mastermind-like domain containing 1 4.71135
CXCR4 chemokine (C-X-C motif) receptor 4 3.94863
NRBF2 nuclear receptor binding factor 2 3.6162
HLA-DRA major histocompatibility complex, class II, DR alpha 2.99517
RPL18 ribosomal protein L18 2.8813
IGHMBP2 immunoglobulin mu binding protein 2 2.5833
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.5455
F2R coagulation factor II (thrombin) receptor 2.53495
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 2.5087
FANCC Fanconi anemia, complementation group C 2.5048
ANKRD11 ankyrin repeat domain 11 2.46905
H2AC25 H2A clustered histone 25 2.4671
PUS3 pseudouridylate synthase 3 2.45405
HABP4 hyaluronan binding protein 4 2.441
UTP11 UTP11 small subunit processome component 2.43765
ACAD8 acyl-CoA dehydrogenase family, member 8 2.42495
THYN1 thymocyte nuclear protein 1 2.4127
TRAPPC4 trafficking protein particle complex 4 2.39855
RPL8 ribosomal protein L8 2.3909
ZNF761 zinc finger protein 761 2.3656
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.3627
LRRC20 leucine rich repeat containing 20 2.3491
PRPF19 pre-mRNA processing factor 19 2.345
RPS25 ribosomal protein S25 2.33735
MARK3 MAP/microtubule affinity-regulating kinase 3 2.315
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.31135
NPAT nuclear protein, ataxia-telangiectasia locus 2.29955
PHC2 polyhomeotic homolog 2 (Drosophila) 2.28795
DSN1 DSN1, MIS12 kinetochore complex component 2.2879
SNX19 sorting nexin 19 2.2837
RPL36A ribosomal protein L36a 2.2761
RPS8 ribosomal protein S8 2.27005
TMEM123 transmembrane protein 123 2.2606
URM1 ubiquitin related modifier 1 2.2422
TARP TCR gamma alternate reading frame protein 2.23671
RPS27A ribosomal protein S27a 2.2239
OXR1 oxidation resistance 1 2.22275
NCOA4 nuclear receptor coactivator 4 2.20685
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.19875
FASTKD3 FAST kinase domains 3 2.18745
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.18485
TBXAS1 thromboxane A synthase 1 (platelet) 2.17095
ATP5MG ATP synthase membrane subunit g 2.16004
REXO5 RNA exonuclease 5 2.1255
NLRX1 NLR family member X1 2.1217
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.10145
SCAF11 SR-related CTD-associated factor 11 2.08177
NCAPD3 non-SMC condensin II complex, subunit D3 2.0694
TROAP trophinin associated protein 2.06225
METTL17 methyltransferase like 17 2.05655
PNPLA3 patatin-like phospholipase domain containing 3 2.0529
MED17 mediator complex subunit 17 2.03845
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.0359
MAGT1 magnesium transporter 1 2.03145
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 2.03055
MFAP1 microfibrillar-associated protein 1 2.00945
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.0087

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -10.0
VIM vimentin -6.16215
REEP5 receptor accessory protein 5 -3.88045
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.77245
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.61392
KRT14 keratin 14, type I -3.44125
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.77705
AGER advanced glycosylation end product-specific receptor -2.68815
SMIM5 small integral membrane protein 5 -2.62075
GLI3 GLI family zinc finger 3 -2.6073
AK6 adenylate kinase 6 -2.60275
LZTR1 leucine-zipper-like transcription regulator 1 -2.56
KRT7 keratin 7, type II -2.55395
AP1M2 adaptor-related protein complex 1, mu 2 subunit -2.51162
HOMER1 homer scaffolding protein 1 -2.49595
SERF1A small EDRK-rich factor 1A (telomeric) -2.47315
OCLN occludin -2.39605
FAM107A family with sequence similarity 107, member A -2.34527
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.30845
IRF6 interferon regulatory factor 6 -2.30455
TLE5 TLE family member 5, transcriptional modulator -2.2888
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.241
TMEM50B transmembrane protein 50B -2.2231
PEX6 peroxisomal biogenesis factor 6 -2.22108
IL6 interleukin 6 -2.20505
S100A8 S100 calcium binding protein A8 -2.1938
TXNDC15 thioredoxin domain containing 15 -2.1674
UBFD1 ubiquitin family domain containing 1 -2.1647
UPK3B uroplakin 3B -2.15395
MAN1C1 mannosidase, alpha, class 1C, member 1 -2.1422
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.1382
TMEM100 transmembrane protein 100 -2.11615
PLPP1 phospholipid phosphatase 1 -2.09445
CA4 carbonic anhydrase IV -2.09215
FCGBP Fc fragment of IgG binding protein -2.07555
GBP2 guanylate binding protein 2, interferon-inducible -2.0748
VEGFD vascular endothelial growth factor D -2.07315
ARID5B AT rich interactive domain 5B (MRF1-like) -2.0698
IL32 interleukin 32 -2.0681
TPO thyroid peroxidase -2.0678
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.05297
SOSTDC1 sclerostin domain containing 1 -2.0421
RAD17 RAD17 homolog (S. pombe) -2.03083
CRELD1 cysteine-rich with EGF-like domains 1 -2.02985
PDIA4 protein disulfide isomerase family A, member 4 -2.02965
KRT20 keratin 20, type I -2.0235
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -2.01785
APOL2 apolipoprotein L, 2 -2.0155
IL11RA interleukin 11 receptor, alpha -2.0098
HHIPL2 HHIP-like 2 -2.0056