CRCGN015_MCF10A_48H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 10.0 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN015_MCF10A_48H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNX11 sorting nexin 11 4.21483
CETN3 centrin, EF-hand protein, 3 3.61355
VAV3 vav 3 guanine nucleotide exchange factor 3.18484
ZW10 zw10 kinetochore protein 3.03214
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.02928
TOMM34 translocase of outer mitochondrial membrane 34 2.75422
TBXA2R thromboxane A2 receptor 2.73286
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.72797
SLC35B1 solute carrier family 35, member B1 2.72565
PCDH12 protocadherin 12 2.69496
HMGA2 high mobility group AT-hook 2 2.62778
WIF1 WNT inhibitory factor 1 2.58613
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.42137
DUSP6 dual specificity phosphatase 6 2.41164
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.40709
MSRA methionine sulfoxide reductase A 2.40538
KIFBP kinesin family binding protein 2.3904
FHL2 four and a half LIM domains 2 2.30846
IDE insulin-degrading enzyme 2.28739
KLHL21 kelch-like family member 21 2.27407
SPRY2 sprouty homolog 2 (Drosophila) 2.27263
KNTC1 kinetochore associated 1 2.25868
GGT5 gamma-glutamyltransferase 5 2.18693
COL4A1 collagen, type IV, alpha 1 2.15189
SNAI2 snail family zinc finger 2 2.14422
TMEM204 transmembrane protein 204 2.14099
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.08861
TEX30 testis expressed 30 2.07227
CDC23 cell division cycle 23 2.06188
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.04843
PIEZO2 piezo-type mechanosensitive ion channel component 2 2.01863
UBE2C ubiquitin-conjugating enzyme E2C 2.00503

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.18763
S100A8 S100 calcium binding protein A8 -4.64882
DDIT4 DNA-damage-inducible transcript 4 -4.27965
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -3.16024
OAT ornithine aminotransferase -3.11275
MT2A metallothionein 2A -3.05617
MVP major vault protein -2.82827
PRR15L proline rich 15-like -2.64104
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.57965
WDR11 WD repeat domain 11 -2.55637
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.48215
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.40805
OXA1L oxidase (cytochrome c) assembly 1-like -2.39623
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.38143
BRMS1L breast cancer metastasis-suppressor 1-like -2.36102
BBS7 Bardet-Biedl syndrome 7 -2.35814
PISD phosphatidylserine decarboxylase -2.31657
ACP6 acid phosphatase 6, lysophosphatidic -2.30054
TM9SF3 transmembrane 9 superfamily member 3 -2.22609
CHI3L2 chitinase 3-like 2 -2.22508
CCNC cyclin C -2.18188
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.17167
TJP3 tight junction protein 3 -2.16786
BLVRB biliverdin reductase B -2.15703
GTF2A2 general transcription factor IIA, 2, 12kDa -2.14969
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.14737
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.14286
FRMD4A FERM domain containing 4A -2.13329
SLC25A46 solute carrier family 25, member 46 -2.13131
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.11266
THAP4 THAP domain containing 4 -2.11208
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.1056
CDC37 cell division cycle 37 -2.07646
INSIG1 insulin induced gene 1 -2.07161
MYO5A myosin VA (heavy chain 12, myoxin) -2.05571
LDAF1 lipid droplet assembly factor 1 -2.02822
DHCR7 7-dehydrocholesterol reductase -2.02477
MFSD6 major facilitator superfamily domain containing 6 -2.02389
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.02121
LRRC8E leucine rich repeat containing 8 family, member E -2.01347
GTPBP8 GTP-binding protein 8 (putative) -2.00886
DHCR24 24-dehydrocholesterol reductase -2.00026