CRCGN015_MCF10A_48H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 3.33 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN015_MCF10A_48H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.55565
ZW10 zw10 kinetochore protein 3.00528
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.93062
MAST2 microtubule associated serine/threonine kinase 2 2.85039
HMGA2 high mobility group AT-hook 2 2.81473
KLHL21 kelch-like family member 21 2.79022
KNTC1 kinetochore associated 1 2.61649
DUSP6 dual specificity phosphatase 6 2.47963
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.29494
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.15497
MAP2K5 mitogen-activated protein kinase kinase 5 2.13934
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.13835
ZWINT ZW10 interacting kinetochore protein 2.12988
XDH xanthine dehydrogenase 2.12421
SPAG4 sperm associated antigen 4 2.03421
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.03369
PAEP progestagen-associated endometrial protein 2.02951
SOX11 SRY (sex determining region Y)-box 11 2.00154

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -7.53054
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -6.62364
S100A8 S100 calcium binding protein A8 -5.97586
INSIG1 insulin induced gene 1 -4.94041
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.44175
PLS1 plastin 1 -4.12685
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.97239
ATG4A autophagy related 4A, cysteine peptidase -3.65053
VIM vimentin -3.39115
HSPA8 heat shock 70kDa protein 8 -2.93388
DCTN3 dynactin 3 (p22) -2.88381
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.68481
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.64207
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.62766
IFI30 interferon, gamma-inducible protein 30 -2.59707
PUF60 poly-U binding splicing factor 60KDa -2.5794
ANXA3 annexin A3 -2.52567
MPC2 mitochondrial pyruvate carrier 2 -2.50653
TNIP1 TNFAIP3 interacting protein 1 -2.49917
DDIT4 DNA-damage-inducible transcript 4 -2.49812
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.48331
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.47808
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.44924
SLC25A46 solute carrier family 25, member 46 -2.43475
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.41347
POF1B premature ovarian failure, 1B -2.4104
CETN2 centrin, EF-hand protein, 2 -2.33814
CLIC3 chloride intracellular channel 3 -2.24282
CRYZ crystallin, zeta (quinone reductase) -2.19951
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.15511
KRT14 keratin 14, type I -2.10843
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.09174
TJP2 tight junction protein 2 -2.0812
PRPF4 pre-mRNA processing factor 4 -2.06139
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.04304
CDK7 cyclin-dependent kinase 7 -2.03675
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.02117
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.01871
MSRB1 methionine sulfoxide reductase B1 -2.01656
TM9SF3 transmembrane 9 superfamily member 3 -2.00467