CRCGN015_MCF10A_48H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 1.11 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

160 genes differentially expressed following the CRCGN015_MCF10A_48H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCQ protein kinase C, theta 3.88056
TBX2 T-box 2 3.80964
GATA3 GATA binding protein 3 3.63608
WIF1 WNT inhibitory factor 1 3.59241
CETN3 centrin, EF-hand protein, 3 3.45188
CNPY3 canopy FGF signaling regulator 3 3.43181
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.39459
TATDN2 TatD DNase domain containing 2 3.31662
C5 complement component 5 3.28583
LAMC3 laminin, gamma 3 3.12238
HBA1 hemoglobin, alpha 1 2.93707
HMGA2 high mobility group AT-hook 2 2.92851
AVPR1B arginine vasopressin receptor 1B 2.86991
DUSP6 dual specificity phosphatase 6 2.76744
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.64563
APOM apolipoprotein M 2.6051
TROAP trophinin associated protein 2.59702
SCIN scinderin 2.5909
HPD 4-hydroxyphenylpyruvate dioxygenase 2.56107
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.49849
ERN2 endoplasmic reticulum to nucleus signaling 2 2.4854
KLHL21 kelch-like family member 21 2.4769
PZP pregnancy-zone protein 2.46651
AMDHD2 amidohydrolase domain containing 2 2.46233
VTN vitronectin 2.44896
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.43366
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.39391
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.39336
BET1L Bet1 golgi vesicular membrane trafficking protein-like 2.39319
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.38324
DENND2A DENN/MADD domain containing 2A 2.3697
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.36596
MAP2K5 mitogen-activated protein kinase kinase 5 2.36205
IHH indian hedgehog 2.35367
DLK2 delta-like 2 homolog (Drosophila) 2.35061
SMAD9 SMAD family member 9 2.3476
MATN4 matrilin 4 2.33513
PRODH2 proline dehydrogenase (oxidase) 2 2.32844
P3H2 prolyl 3-hydroxylase 2 2.32371
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.32171
SIM2 single-minded family bHLH transcription factor 2 2.32119
MMP26 matrix metallopeptidase 26 2.31702
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.31243
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.31204
POMT2 protein-O-mannosyltransferase 2 2.31029
HYOU1 hypoxia up-regulated 1 2.29554
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.28176
EDA2R ectodysplasin A2 receptor 2.24757
ADAMTSL3 ADAMTS-like 3 2.24203
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.24075
APOA1 apolipoprotein A-I 2.23437
ANGPT4 angiopoietin 4 2.23368
MATN1 matrilin 1, cartilage matrix protein 2.22414
APOA2 apolipoprotein A-II 2.22135
HDAC11 histone deacetylase 11 2.21717
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.20684
AHSG alpha-2-HS-glycoprotein 2.20118
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.19696
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.18531
MYF6 myogenic factor 6 (herculin) 2.18425
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.183
LMO1 LIM domain only 1 (rhombotin 1) 2.18156
LHX5 LIM homeobox 5 2.17752
PTH1R parathyroid hormone 1 receptor 2.15768
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.15746
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.15338
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.14334
CNPY3-GNMT CNPY3-GNMT readthrough 2.14213
JPH2 junctophilin 2 2.1385
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.12764
NGB neuroglobin 2.12336
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.11064
ADAMTSL2 ADAMTS-like 2 2.10194
LPAR3 lysophosphatidic acid receptor 3 2.10067
DUSP9 dual specificity phosphatase 9 2.09158
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.09017
ZNF862 zinc finger protein 862 2.08838
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.08775
RPL10L ribosomal protein L10-like 2.08443
HOXA10 homeobox A10 2.08061
TRMT61A tRNA methyltransferase 61A 2.08056
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.07895
ZNF280B zinc finger protein 280B 2.07871
PTCH2 patched 2 2.0784
MYOM2 myomesin 2 2.06716
FOXM1 forkhead box M1 2.06251
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 2.05804
SSTR1 somatostatin receptor 1 2.05803
BHMT betaine--homocysteine S-methyltransferase 2.05772
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.04585
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.04516
ZW10 zw10 kinetochore protein 2.04424
ENO2 enolase 2 (gamma, neuronal) 2.04372
COG7 component of oligomeric golgi complex 7 2.04285
OSBP2 oxysterol binding protein 2 2.0407
FAM169A family with sequence similarity 169, member A 2.03651
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.02792
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.0261
LRP3 low density lipoprotein receptor-related protein 3 2.0204
SEC61G Sec61 gamma subunit 2.02007
SMG6 SMG6 nonsense mediated mRNA decay factor 2.01702
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.01537
AMH anti-Mullerian hormone 2.00474
PLCL1 phospholipase C-like 1 2.00394
HGFAC HGF activator 2.00135

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -7.68076
S100A8 S100 calcium binding protein A8 -4.85612
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.8092
SAMD9 sterile alpha motif domain containing 9 -3.21734
FBXO7 F-box protein 7 -3.01981
INSIG1 insulin induced gene 1 -2.83403
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.81918
WASHC4 WASH complex subunit 4 -2.77735
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.71615
ANXA3 annexin A3 -2.6631
LOC124907782 dual specificity protein phosphatase 22 -2.64407
SPRR2B small proline-rich protein 2B -2.61371
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -2.57895
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.53816
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.52522
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.47311
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.43754
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.43655
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -2.36544
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.36072
TRIM16 tripartite motif containing 16 -2.35196
STAP2 signal transducing adaptor family member 2 -2.34935
PISD phosphatidylserine decarboxylase -2.34814
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.34487
GLRX glutaredoxin (thioltransferase) -2.33408
SLC25A46 solute carrier family 25, member 46 -2.32063
SQLE squalene epoxidase -2.30513
CRNN cornulin -2.25925
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.25918
ELOVL6 ELOVL fatty acid elongase 6 -2.25488
E2F5 E2F transcription factor 5, p130-binding -2.20814
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.20207
RAB9A RAB9A, member RAS oncogene family -2.20091
CREB1 cAMP responsive element binding protein 1 -2.1961
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.18766
POF1B premature ovarian failure, 1B -2.18326
H2AC6 H2A clustered histone 6 -2.17637
ZMPSTE24 zinc metallopeptidase STE24 -2.16646
ATG4A autophagy related 4A, cysteine peptidase -2.15492
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -2.15119
TMEM135 transmembrane protein 135 -2.14377
CDK7 cyclin-dependent kinase 7 -2.10114
FOXO4 forkhead box O4 -2.09844
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.09789
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.09577
RHOB ras homolog family member B -2.07805
NOD1 nucleotide-binding oligomerization domain containing 1 -2.07317
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.07195
LDHB lactate dehydrogenase B -2.04191
LGALSL lectin, galactoside-binding-like -2.04045
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.03414
DYNLT3 dynein, light chain, Tctex-type 3 -2.03198
MVP major vault protein -2.02835
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.02627
LOC128966597 MAL-like protein -2.01674