CRCGN015_MCF10A_48H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 33.0 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN015_MCF10A_48H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LOC122526780 uncharacterized LOC122526780 3.51785
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.37589
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.84809
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.83122
LOXL1 lysyl oxidase-like 1 2.82187
SESN1 sestrin 1 2.64204
SSX5 synovial sarcoma, X breakpoint 5 2.39282
SP140L SP140 nuclear body protein-like 2.23728
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.1997
MTA2 metastasis associated 1 family, member 2 2.1307
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.05247
UTRN utrophin 2.0356
INCENP inner centromere protein antigens 135/155kDa 2.02875
APOLD1 apolipoprotein L domain containing 1 2.02387
RRAGB Ras-related GTP binding B 2.02343
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.01812
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.01659
PLVAP plasmalemma vesicle associated protein 2.005

decreased expression

Symbol Name Standardized Value
MRPS16 mitochondrial ribosomal protein S16 -3.70862
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.44375
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.38498
MAPK13 mitogen-activated protein kinase 13 -2.73077
PLK2 polo-like kinase 2 -2.72287
HSPA8 heat shock 70kDa protein 8 -2.31878
PLK1 polo-like kinase 1 -2.13077