CRCGN015_MCF10A_48H:G24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 11.1 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN015_MCF10A_48H:G24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.50713
CXCL2 chemokine (C-X-C motif) ligand 2 4.62311
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.92306
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.62349
HBA1 hemoglobin, alpha 1 3.05282
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.91777
GRB10 growth factor receptor-bound protein 10 2.65491
TRIB3 tribbles pseudokinase 3 2.56123
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.42417
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.36349
TMEM80 transmembrane protein 80 2.1027
JAG2 jagged 2 2.02454

decreased expression

Symbol Name Standardized Value
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -5.44065
KRT14 keratin 14, type I -4.53497
MSMO1 methylsterol monooxygenase 1 -4.47474
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.43997
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.74702
PLK2 polo-like kinase 2 -3.6903
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.24872
SYTL3 synaptotagmin-like 3 -2.20582
ANXA3 annexin A3 -2.11428
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.095
DDA1 DET1 and DDB1 associated 1 -2.04879
FAM20B family with sequence similarity 20, member B -2.01788
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.00377
CCDC88C coiled-coil domain containing 88C -2.00144