CRCGN015_MCF10A_48H:H11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description maleic hydrazide 33.1 um perturbation at 48 h in MCF10A (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

69 genes differentially expressed following the CRCGN015_MCF10A_48H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.39985
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.78657
MAPK9 mitogen-activated protein kinase 9 2.62405
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.54525
NSUN3 NOP2/Sun domain family, member 3 2.47305
COMMD3 COMM domain containing 3 2.4213
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.3888
DHDDS dehydrodolichyl diphosphate synthase 2.37077
ATP5PF ATP synthase peripheral stalk subunit F6 2.34995
HACD1 3-hydroxyacyl-CoA dehydratase 1 2.3129
NPY neuropeptide Y 2.28605
KIF1B kinesin family member 1B 2.22995
FUCA1 fucosidase, alpha-L- 1, tissue 2.22635
UFSP2 UFM1-specific peptidase 2 2.21805
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.1894
EVL Enah/Vasp-like 2.18395
BCL7B B-cell CLL/lymphoma 7B 2.17615
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.1092
NCOA4 nuclear receptor coactivator 4 2.0597

decreased expression

Symbol Name Standardized Value
HEATR1 HEAT repeat containing 1 -4.30297
VIM vimentin -3.13705
KRT14 keratin 14, type I -2.74485
GRB7 growth factor receptor-bound protein 7 -2.5938
ZDHHC13 zinc finger, DHHC-type containing 13 -2.5129
DSG3 desmoglein 3 -2.4552
KRT7 keratin 7, type II -2.4113
MMP10 matrix metallopeptidase 10 -2.2929
PDCD1LG2 programmed cell death 1 ligand 2 -2.29185
DUSP7 dual specificity phosphatase 7 -2.2842
ALAS1 5'-aminolevulinate synthase 1 -2.27445
EVPL envoplakin -2.273
LOC124906280 uncharacterized LOC124906280 -2.2622
MCHR1 melanin-concentrating hormone receptor 1 -2.2518
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.24825
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 -2.22465
ALOX15 arachidonate 15-lipoxygenase -2.21745
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.2069
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 -2.1903
CXCR1 chemokine (C-X-C motif) receptor 1 -2.1771
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound -2.17602
GJB5 gap junction protein, beta 5, 31.1kDa -2.16645
EPHB3 EPH receptor B3 -2.15745
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.15335
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -2.14065
GLTP glycolipid transfer protein -2.1404
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -2.1331
PRODH2 proline dehydrogenase (oxidase) 2 -2.13135
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.12225
KREMEN2 kringle containing transmembrane protein 2 -2.1186
AICDA activation-induced cytidine deaminase -2.10735
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.0805
CLDN16 claudin 16 -2.07165
CCNP cyclin P -2.0713
RASAL1 RAS protein activator like 1 (GAP1 like) -2.06875
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.0662
DPYS dihydropyrimidinase -2.06345
S1PR5 sphingosine-1-phosphate receptor 5 -2.06335
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.06215
PCDH12 protocadherin 12 -2.0617
MYO15A myosin XVA -2.04265
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.0332
ARC activity-regulated cytoskeleton-associated protein -2.0253
IL23A interleukin 23, alpha subunit p19 -2.02445
GSTA1 glutathione S-transferase alpha 1 -2.0224
RLBP1 retinaldehyde binding protein 1 -2.0199
CDON cell adhesion associated, oncogene regulated -2.01875
LRRC2 leucine rich repeat containing 2 -2.0099
GLI2 GLI family zinc finger 2 -2.00965
ORAI3 ORAI calcium release-activated calcium modulator 3 -2.0041