CRCGN015_MCF10A_48H:H13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl methacrylate 98.44 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

227 genes differentially expressed following the CRCGN015_MCF10A_48H:H13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.33935
ABHD6 abhydrolase domain containing 6 5.08212
PDIA5 protein disulfide isomerase family A, member 5 4.376
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3.70578
NBPF19 neuroblastoma breakpoint family, member 19 3.11135
FAM107A family with sequence similarity 107, member A 3.03258
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.9649
JAKMIP2 janus kinase and microtubule interacting protein 2 2.95843
NBPF10 neuroblastoma breakpoint family, member 10 2.9516
ADGRG2 adhesion G protein-coupled receptor G2 2.94545
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.92795
NKX2-2 NK2 homeobox 2 2.9089
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.83775
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 2.82865
ODF2 outer dense fiber of sperm tails 2 2.80735
UGT8 UDP glycosyltransferase 8 2.79785
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.7581
EXPH5 exophilin 5 2.7124
MEIS1 Meis homeobox 1 2.69365
JAM2 junctional adhesion molecule 2 2.68705
EPN2 epsin 2 2.68402
IPO8 importin 8 2.61635
FBLN5 fibulin 5 2.59655
CCNT1 cyclin T1 2.56795
ART3 ADP-ribosyltransferase 3 2.55305
ZNF672 zinc finger protein 672 2.5471
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.54605
GTF2H2C GTF2H2 family member C 2.5235
LPAR1 lysophosphatidic acid receptor 1 2.50722
SPATA6 spermatogenesis associated 6 2.50548
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 2.49822
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.4962
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.48785
AZIN1 antizyme inhibitor 1 2.48467
RNMT RNA (guanine-7-) methyltransferase 2.47805
PSEN1 presenilin 1 2.4566
CTNND2 catenin (cadherin-associated protein), delta 2 2.41625
OSR2 odd-skipped related transciption factor 2 2.41485
SETD5 SET domain containing 5 2.39545
PALLD palladin, cytoskeletal associated protein 2.37238
YBX1 Y box binding protein 1 2.36217
GDI2 GDP dissociation inhibitor 2 2.3368
NLGN4X neuroligin 4, X-linked 2.3327
DCAF10 DDB1 and CUL4 associated factor 10 2.3309
ASCC1 activating signal cointegrator 1 complex subunit 1 2.31985
EP400 E1A binding protein p400 2.3196
FAM169A family with sequence similarity 169, member A 2.31345
NFX1 nuclear transcription factor, X-box binding 1 2.29112
FPGS folylpolyglutamate synthase 2.25675
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.2549
USO1 USO1 vesicle transport factor 2.24
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.23455
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 2.23417
RLIM ring finger protein, LIM domain interacting 2.22375
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.2189
TNRC6B trinucleotide repeat containing 6B 2.21695
NOTCH2 notch 2 2.2154
TPCN1 two pore segment channel 1 2.2059
S100PBP S100P binding protein 2.20425
AQP4 aquaporin 4 2.20186
PCM1 pericentriolar material 1 2.19835
HOOK1 hook microtubule-tethering protein 1 2.1982
LRRC59 leucine rich repeat containing 59 2.19035
COBL cordon-bleu WH2 repeat protein 2.18595
ARFIP1 ADP-ribosylation factor interacting protein 1 2.184
IGFBP6 insulin-like growth factor binding protein 6 2.18385
IPO5 importin 5 2.17831
ADD3 adducin 3 (gamma) 2.17453
KDSR 3-ketodihydrosphingosine reductase 2.17175
UBA1 ubiquitin-like modifier activating enzyme 1 2.16625
TUBGCP4 tubulin, gamma complex associated protein 4 2.16045
PRRX1 paired related homeobox 1 2.16
RDX radixin 2.15183
PAQR3 progestin and adipoQ receptor family member III 2.15125
APLNR apelin receptor 2.1498
FBN1 fibrillin 1 2.14848
CNTN1 contactin 1 2.14515
TMEM100 transmembrane protein 100 2.14475
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.14355
CLMN calmin (calponin-like, transmembrane) 2.13995
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.1294
SAV1 salvador family WW domain containing protein 1 2.12185
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.1134
PLLP plasmolipin 2.1041
CD81 CD81 molecule 2.10325
TMEM260 transmembrane protein 260 2.10135
GPSM2 G-protein signaling modulator 2 2.09885
RBM10 RNA binding motif protein 10 2.0899
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 2.08973
ZNF665 zinc finger protein 665 2.087
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.07125
MTUS1 microtubule associated tumor suppressor 1 2.06925
HIPK1 homeodomain interacting protein kinase 1 2.06685
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.06575
SYTL3 synaptotagmin-like 3 2.0584
ASPA aspartoacylase 2.04825
IL1A interleukin 1, alpha 2.0422
ADAM28 ADAM metallopeptidase domain 28 2.03487
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.03265
ASRGL1 asparaginase like 1 2.0147
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.01425
CLASP2 cytoplasmic linker associated protein 2 2.01142
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.0099
BAALC brain and acute leukemia, cytoplasmic 2.00915
CGGBP1 CGG triplet repeat binding protein 1 2.00875
CAPRIN1 cell cycle associated protein 1 2.0061
CD99 CD99 molecule 2.00192
IPP intracisternal A particle-promoted polypeptide 2.00115

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -7.5688
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -5.21715
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.04455
PCCB propionyl CoA carboxylase, beta polypeptide -5.0103
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.0
TXNDC9 thioredoxin domain containing 9 -4.98907
RPA3 replication protein A3, 14kDa -4.78005
NCK1 NCK adaptor protein 1 -4.63892
DSG2 desmoglein 2 -4.4595
MT2A metallothionein 2A -4.2061
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.99242
LMAN2L lectin, mannose-binding 2-like -3.87735
JMJD6 jumonji domain containing 6 -3.72808
PLK2 polo-like kinase 2 -3.63585
ZDHHC4 zinc finger, DHHC-type containing 4 -3.59035
PDCL3 phosducin-like 3 -3.46125
COXFA4 cytochrome c oxidase associated subunit FA4 -3.38865
SEC61G Sec61 gamma subunit -3.38545
KCMF1 potassium channel modulatory factor 1 -3.23255
STAT1 signal transducer and activator of transcription 1, 91kDa -3.15619
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.12835
REV1 REV1, polymerase (DNA directed) -3.0874
GGCT gamma-glutamylcyclotransferase -2.9929
COX5B cytochrome c oxidase subunit Vb -2.8827
NUSAP1 nucleolar and spindle associated protein 1 -2.87267
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.86483
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.84587
CCL20 chemokine (C-C motif) ligand 20 -2.82485
CD24 CD24 molecule -2.82122
MT1X metallothionein 1X -2.7735
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.7652
UNC50 unc-50 homolog (C. elegans) -2.72605
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.6512
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.64395
JCHAIN joining chain of multimeric IgA and IgM -2.61495
PCBP3 poly(rC) binding protein 3 -2.6143
MRPS17 mitochondrial ribosomal protein S17 -2.5407
EPHX3 epoxide hydrolase 3 -2.52905
BCKDK branched chain ketoacid dehydrogenase kinase -2.5266
ATP5F1E ATP synthase F1 subunit epsilon -2.50765
TMEM127 transmembrane protein 127 -2.5065
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.50095
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.47575
TRMT61B tRNA methyltransferase 61B -2.46275
MRM2 mitochondrial rRNA methyltransferase 2 -2.44055
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.43745
GCC2 GRIP and coiled-coil domain containing 2 -2.4352
COMMD9 COMM domain containing 9 -2.4247
CTNND1 catenin (cadherin-associated protein), delta 1 -2.41888
TACSTD2 tumor-associated calcium signal transducer 2 -2.41645
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.4164
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.41005
PDCD10 programmed cell death 10 -2.40025
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -2.39595
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.39575
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.3821
MCTS1 malignant T cell amplified sequence 1 -2.37565
ORC4 origin recognition complex, subunit 4 -2.36055
ATG4A autophagy related 4A, cysteine peptidase -2.34345
MOB4 MOB family member 4, phocein -2.34145
CREBL2 cAMP responsive element binding protein-like 2 -2.33303
EDAR ectodysplasin A receptor -2.3325
HINT1 histidine triad nucleotide binding protein 1 -2.33197
CHSY1 chondroitin sulfate synthase 1 -2.3305
RWDD3 RWD domain containing 3 -2.3235
NFU1 NFU1 iron-sulfur cluster scaffold -2.32255
CRIP2 cysteine-rich protein 2 -2.3062
METTL9 methyltransferase like 9 -2.28745
MAD2L1BP MAD2L1 binding protein -2.27215
ANXA8L1 annexin A8-like 1 -2.26805
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.24467
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.23595
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.2348
FKBP9 FK506 binding protein 9, 63 kDa -2.22685
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.2255
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.2167
LIPT1 lipoyltransferase 1 -2.19925
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.18138
TUBA4A tubulin, alpha 4a -2.17305
SNRPG small nuclear ribonucleoprotein polypeptide G -2.1677
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.1667
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -2.16165
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.1585
SNRPE small nuclear ribonucleoprotein polypeptide E -2.155
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough -2.14375
NTAN1 N-terminal asparagine amidase -2.14188
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.13745
CYTIP cytohesin 1 interacting protein -2.1292
CRHBP corticotropin releasing hormone binding protein -2.1288
GYPC glycophorin C (Gerbich blood group) -2.1198
MLH1 mutL homolog 1 -2.11935
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.11762
RNFT1-DT RNFT1 divergent transcript -2.09525
MRPS22 mitochondrial ribosomal protein S22 -2.08875
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.0821
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -2.0788
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.0773
KRT17 keratin 17, type I -2.07425
MNT MAX network transcriptional repressor -2.07315
TSPOAP1 TSPO associated protein 1 -2.07305
CETN2 centrin, EF-hand protein, 2 -2.0708
ARMCX5 armadillo repeat containing, X-linked 5 -2.0653
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.06385
PDZK1IP1 PDZK1 interacting protein 1 -2.06145
ZFPM1 zinc finger protein, FOG family member 1 -2.0603
BAHD1 bromo adjacent homology domain containing 1 -2.0527
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.03675
WIPI2 WD repeat domain, phosphoinositide interacting 2 -2.0339
JUP junction plakoglobin -2.0313
RGS4 regulator of G-protein signaling 4 -2.0312
BABAM1 BRISC and BRCA1 A complex member 1 -2.02835
MBD5 methyl-CpG binding domain protein 5 -2.028
MRPL49 mitochondrial ribosomal protein L49 -2.02745
ARMCX1 armadillo repeat containing, X-linked 1 -2.0238
STAT5A signal transducer and activator of transcription 5A -2.02365
LOC124906748 beta-defensin 4A -2.0128
SFRP5 secreted frizzled-related protein 5 -2.0041
ZNF12 zinc finger protein 12 -2.00185
ATRAID all-trans retinoic acid-induced differentiation factor -2.00065