CRCGN015_MCF10A_48H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 33.15 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

19 genes differentially expressed following the CRCGN015_MCF10A_48H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.9023
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.87815
FPGS folylpolyglutamate synthase 3.70015
MAPK9 mitogen-activated protein kinase 9 3.22607
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.0637
RPL39L ribosomal protein L39-like 2.5909
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.58775
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.5033
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.2273
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.1463
F2R coagulation factor II (thrombin) receptor 2.11005
HJURP Holliday junction recognition protein 2.02335

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -5.18855
S100A8 S100 calcium binding protein A8 -3.4065
CREG1 cellular repressor of E1A-stimulated genes 1 -3.38
KRT14 keratin 14, type I -3.2996
DEPTOR DEP domain containing MTOR-interacting protein -2.6512
IL22RA1 interleukin 22 receptor, alpha 1 -2.30955
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.0143